Survey on Pattern Identification and Treatment of Chronic Fatigue in Korea Medicine

Kim, Ji Won; Kim, Hyo Jin; Jang, Eun Su; Jung, Hyun Chul; Hwang, Min-Woo; Nam, Dong Hyun

doi:10.15188/kjopp.2018.04.32.2.126

Cited by 7 publications

(3 citation statements)

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“…Bojungikgi-tang (CV1), herbal medicine that will be administered to the fatigue group in the present study, has been investigated as the most frequently prescribed herbal medicine for the treatment and management of chronic fatigue by KMDs [ 21 ], and our systematic literature review reveals that Bojungikgi-tang has a significant effect in alleviating the symptoms of CFS compared to health supplements or symptomatic treatments. [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Herbal Medicines for Post-Acute Sequelae (Fatigue or Cognitive Dysfunction) of SARS-CoV-2 Infection: A Phase 2 Pilot Clinical Study Protocol

et al. 2022

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Long-term sequelae refer to persistent symptoms or signs for >6 months after SARS-CoV-2 infection. The most common symptoms of sequelae are fatigue and neuropsychiatric symptoms (concentration difficulty, amnesia, cognitive dysfunction, anxiety, and depression). However, approved treatments have not been fully established. Herbal medicines are administered for 12 weeks to patients who continuously complain of fatigue or cognitive dysfunction for >4 weeks that only occurred after COVID-19 diagnoses. Based on the Korean Medicine syndrome differentiation diagnosis, patients with fatigue will be administered Bojungikgi-tang or Kyungok-go, whereas those with cognitive dysfunction will be administered Cheonwangbosim-dan. Results could support evidence that herbal medicines may mitigate fatigue and cognitive dysfunction caused by COVID-19. Furthermore, by investigating the effects of herbal medicines on changes in metabolite and immune response due to COVID-19, which may be responsible for sequelae, the potential of herbal medicines as one of the therapeutic interventions for post-acute sequelae of SARS-CoV-2 infection can be evaluated. Therefore, the effects of herbal medicine on fatigue and cognitive dysfunction sequelae due to COVID-19 will be elucidated in this study to provide an insight into the preparation of medical management for the post-acute sequelae of SARS-CoV-2 infection.

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Section: Discussionmentioning

confidence: 99%

Herbal Medicines for Post-Acute Sequelae (Fatigue or Cognitive Dysfunction) of SARS-CoV-2 Infection: A Phase 2 Pilot Clinical Study Protocol

et al. 2022

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“…While this may be related to PSF, insufficient studies have been conducted on this relationship. Kim et al [ 26 ] reported that bojungikgi-tang, ssanghwa-tang, and sipjeondaebo-tang were frequently prescribed for patients with chronic fatigue syndrome or idiopathic chronic fatigue. Astragalus membranaceus and Panax ginseng in bojungikgi-tang, Astragalus membranaceus and Cinnamomum cassia in sipjeondaebo-tang, and Astragalus membranaceus and Cinnamomi ramulus in ssanghwa-tang are warm medicinal herbs widely used for treating cold syndrome [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

An Analysis of Characteristics of Post-Stroke Fatigue in Patients without Depression: A Retrospective Chart Review

et al. 2021

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Post-stroke fatigue (PSF) is among the most common stroke sequelae and affects rehabilitation, resulting in poor recovery. A main influencing factor may be depression, which has been investigated with fatigue in several clinical trials. We aimed to evaluate the characteristics of fatigue in post-stroke patients without depression through a retrospective chart review. The medical records of stroke patients hospitalized in the Stroke and Brain Disease Center, Kyung Hee University Korean Medicine Hospital were reviewed. Stroke patients without depression were divided into a PSF group and control group (without fatigue). The demographic characteristics, type of stroke, medical history, laboratory examinations, clinical features, and pattern identification of each patient were recorded and compared between the study groups. The medical records of 216 patients were reviewed; 85 and 131 patients were assigned to the PSF and control group, respectively. Apolipoprotein A1 levels were significantly lower in the PSF than in the control group (105.6 ± 16.5 vs. 116.2 ± 21.8). We found a significantly higher occurrence of reversal cold of the extremities and a lower probability of fire-heat pattern in the PSF group than in the control group. This study suggests that apolipoprotein A1 levels are lower and cold manifestations are more common in PSF patients without depression than in those without fatigue.

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“…만성피로증후군 진단기준은 1988년 미국 질병통제예방센터(centers for disease control and prevention; CDC)에 의해 처음으로 제안되었으며 2) , 이후 다양한 진단기준들이 제안되어 왔다 [3][4][5][6][7] . 1994년 에 제안된 CDC 진단기준 1) 은 현재 가장 널리 사용되 고 있는 만성피로증후군 진단기준이며 8,9) , 이 진단기 준은 2005년에 부분적으로 수정되었다 10) . 한편 특발 성만성피로는 6개월 이상 지속되는 만성 재발성 피 로가 나타나면서, 만성피로증후군의 8가지 주요 증상 들 중 3가지 이하 만을 충족하는 경우에 진단될 수 있다 1) .…”

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The Effectiveness of Bojungikgi-tang and its modifications on Chronic Fatigue Syndrome: A Systematic Review And Meta-analysis

Nam

2020

J Korean Med

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The aim of this review is to ascertain whether Bojungikgi-tang and its modifications is more effective than non-specific management in chronic fatigue syndrome (CFS). Methods: We collected clinical trials to investigate the effects of Bojungikgi-tang and non-specific management on general symptoms, fatigue, and sleep quality in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, CNKI, VIP, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found records according to prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified on the basis of interventions in experimental group. Results: Seven randomized controlled trials (476 participants) were eligible and their results were synthesized in the meta-analysis. The synthesis showed a substantial effect of Bojungikgi-tang (relative risk 0.20 [95% CI 0.13 to 0.31], Z=7.44, P<0.00001; I 2 =0%) and combination of Bojungikgi-tang and Sosiho-tang (relative risk 0.15 [95% CI 0.08 to 0.28], Z=5.85, P<0.00001; I 2 =0%) compared with non-specific management on improvement of general symptoms. However, we could not find sufficient clinical research records to determine their effects of improvement on fatigue and sleep quality. Conclusions: Bojungikgi-tang and its modifications are more effective than non-specific management for improvement of general symptoms in CFS post-treatment.

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Survey on Pattern Identification and Treatment of Chronic Fatigue in Korea Medicine

Cited by 7 publications

References 0 publications

Herbal Medicines for Post-Acute Sequelae (Fatigue or Cognitive Dysfunction) of SARS-CoV-2 Infection: A Phase 2 Pilot Clinical Study Protocol

Herbal Medicines for Post-Acute Sequelae (Fatigue or Cognitive Dysfunction) of SARS-CoV-2 Infection: A Phase 2 Pilot Clinical Study Protocol

An Analysis of Characteristics of Post-Stroke Fatigue in Patients without Depression: A Retrospective Chart Review

The Effectiveness of Bojungikgi-tang and its modifications on Chronic Fatigue Syndrome: A Systematic Review And Meta-analysis

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