Survey on current cognitive practices within the European Low-Grade Glioma Network: towards a European assessment protocol

Rofes, Adrià; Mandonnet, Emmanuel; Godden, John O.; Baron, Marie; Colle, Herbert A.; Darlix, Amélie; Aguiar, Vânia de; Duffau, Hugues; Herbet, Guillaume; Klein, Martin; Lubrano, V.; Martino, Juan; Mathew, Ryan; Miceli, Gabriele; Moritz‐Gasser, Sylvie; Pallud, Johan; Papagno, Costanza; Rech, Fabien; Espesser, Robert; Rutten, Geert‐Jan; Santarius, Thomas; Satoer, Djaina; Sierpowska, Joanna; Smits, Anja; Škrap, Miran; Spena, Giannantonio; Visch, Evy; Witte, Elke De; Zetterling, Maria; Wager, Michel

doi:10.1007/s00701-017-3192-2

Cited by 89 publications

(36 citation statements)

References 76 publications

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“…Fluency tasks are commonly used to assess people with different neurological disorders, including people with Alzheimer’s disease (AD) (e.g., Monsch et al, 1992 ; Cohen et al, 1999 ; Quinn et al, 2012 ; Shao et al, 2014 ; Rodrigues et al, 2015 ; Rofes et al, 2017 , 2019 ). Typically, researchers and clinicians ask participants to name as many words as possible starting with a common category (e.g., animals, fruits, vegetables) or with a common letter (e.g., F, A, S).…”

Section: Introductionmentioning

confidence: 99%

What Drives Task Performance During Animal Fluency in People With Alzheimer’s Disease?

et al. 2020

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Background Animal fluency is a widely used task to assess people with Alzheimer’s disease (AD) and other neurological disorders. The mechanisms that drive performance in this task are argued to rely on language and executive functions. However, there is little information regarding what specific aspects of these cognitive processes drive performance on this task. Objective To understand which aspects of language (i.e., semantics, phonological output lexicon, phonological assembly) and executive function (i.e., mental set shifting; information updating and monitoring; inhibition of possible responses) are involved in the performance of animal fluency in people with AD. Methods Animal fluency data from 58 people with probable AD from the DementiaBank Pittsburgh Corpus were analyzed. Number of clusters and switches were measured and nine word properties (e.g., frequency, familiarity) for each of the correct words (i.e., each word counting toward the total score, disregarding non-animals and repetitions) were determined. Random forests were used to understand which variables predicted the total number of correct words, and conditional inference trees were used to search for interactions between the variables. Finally, Wilcoxon tests were implemented to cross-validate the results, by comparing the performance of participants with scores below the norm in animal fluency against participants with scores within the norm based on a large normative sample. Results Switches and age of acquisition emerged as the most important variables to predict total number of correct words in animal fluency in people with AD. Cross-validating the results, people with AD whose animal fluency scores fell below the norm produced fewer switches and words with lower age of acquisition than people with AD with scores in the normal range. Conclusion The results indicate that people with AD rely on executive functioning (information updating and monitoring) and language (phonological output lexicon, not necessarily semantics) to produce words on animal fluency.

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Section: Introductionmentioning

confidence: 99%

What Drives Task Performance During Animal Fluency in People With Alzheimer’s Disease?

et al. 2020

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“…Yet, 80% of European centers prefer invasive intraoperative direct electrical cortical and subcortical stimulation over noninvasive procedures for the determination of eloquent cortex, which reflects commonly agreed practice and level of evidence [ 55 – 57 ].…”

Section: Discussionmentioning

confidence: 99%

Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging

et al. 2018

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ObjectiveImaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers.MethodsAn online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery.ResultsA total of 128 fully completed surveys were received and analyzed. Most centers (n = 96, 75%) were academic and half of the centers (n = 64, 50%) adhered to a dedicated treatment program for DLGG. There were national differences regarding the sequences enclosed in MRI imaging and use of PET, however most included T1 (without and with contrast, 100%), T2 (100%) and TIRM or FLAIR (20, 98%). DWI is performed by 80% of centers and 61% of centers regularly performed PWI.ConclusionA minimal core of imaging composed of T1 (w/wo contrast), T2, TIRM/FLAIR, PWI and DWI could be identified. All morphologic images should be obtained in a slice thickness of ≤ 3 mm. No common standard could be obtained regarding advanced MRI protocols and PET.Importance of the studyWe believe that our study makes a significant contribution to the literature because we were able to determine similarities in numerous aspects of LGG imaging. Using the proposed “minimal core of imaging” in clinical routine will facilitate future cooperative studies.Electronic supplementary materialThe online version of this article (10.1007/s11060-018-2916-3) contains supplementary material, which is available to authorized users.

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“…Spontaneous speech tasks are used to assess and characterize language production in people with neurological deficits such as stroke [1], brain tumors [2], and neurodegenerative diseases [3]. Patients are typically asked to describe a picture, respond to an open-ended question, or tell a story [4].…”

Section: A Traditional Speech-based Assessmentmentioning

confidence: 99%

“…Thus, transcripts fed to the tagger lack periods and commas. 2 They also ignore fillers, such as um's and ah's. Fillers were transcribed in the current dataset, but we removed them to best approximate current off-the-shelf AT.…”

Section: E Off-the-shelf and Baseline Perspectivementioning

confidence: 99%

A "Verbal Thermometer" for Assessing Neurodegenerative Disease: Automated Measurement of Pronoun and Verb Ratio from Speech

Jarrold

Rofes

Wilson

et al. 2020

2020 42nd Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Clinicians often use speech to characterize neurodegenerative disorders. Such characterizations require clinical judgment, which is subjective and can require extensive training. Quantitative Production Analysis (QPA) can be used to obtain objective quantifiable assessments of patient functioning. However, such human-based analyses of speech are costly and time consuming. Inexpensive off-the-shelf technologies such as speech recognition and part of speech taggers may avoid these problems. This study evaluates the ability of an automatic speech to text transcription system and a part of speech tagger to assist with measuring pronoun and verb ratios, measures based on QPA. Five participant groups provided spontaneous speech samples. One group consisted of healthy controls, while the remaining groups represented four subtypes of frontotemporal dementia. Findings indicated measurement of pronoun and verb ratio was robust despite errors introduced by automatic transcription and the tagger and despite these off-the-shelf products not having been trained on the language obtained from speech of the included population. Clinical relevance Linguistic differences in individuals with neurodegenerative disease can be subtle. Automated measurement of pronoun and verb ratio (PR and VR) showed promise despite the early stage of pipeline development using off-theshelf tools. Intraclass correlations between automatic versus human measures of PR and VR were in the moderate to excellent range as measured by intra-class correlation.

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Survey on current cognitive practices within the European Low-Grade Glioma Network: towards a European assessment protocol

Abstract: There is an emerging trend towards following similar practices for the management of low-grade gliomas in Europe. Our results are descriptive and formalise current discussions in our group. Also, they contribute towards the development of a European assessment protocol.

Cited by 89 publications

References 76 publications

What Drives Task Performance During Animal Fluency in People With Alzheimer’s Disease?

What Drives Task Performance During Animal Fluency in People With Alzheimer’s Disease?

Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging

A "Verbal Thermometer" for Assessing Neurodegenerative Disease: Automated Measurement of Pronoun and Verb Ratio from Speech

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