Survey and Management Outcome of Neonatal Jaundice from a Developing Tertiary Health Centre, Southern Nigeria.

Omekwe, Dakoru Edoghotu; George, Mukoro Duke; Kennis, Briseimo T.; Fakuma, Benson Nana; Evidence, Chilunum Chioma; Destiny, Ebitimi Fiyebobra; Seimiekumo, Fawei Erepamo; Owoeye, Gani I.O.

doi:10.9790/0853-13413539

Cited by 13 publications

(14 citation statements)

References 3 publications

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“…The odds of NNJ were 5.06 times more likely among neonates with birth weight less than 2500 g than neonates with normal birth weight. This finding was in line with studies conducted in Tehran Iran, 31 Kerala India, 36 North India, 37 Nepal, 32 South Nigeria 38 and Ghana. 33 This might be due to the fact that most of the time low birth weight is common in newborns with prematurity the presents with immature organs particularly immature liver which fails to conjugate normally produced bilirubin from red blood cell which results in jaundices.…”

Section: Discussionsupporting

confidence: 92%

“…The odds of NNJ were 2.88 times more likely among neonates with birth asphyxia than neonates without birth asphyxia. Different studies conducted in Kerala India, 36 Southern Nigeria 38 and Southeastern Nigeria 40 supported that NNJs are influenced by birth asphyxia. This might be due to the fact that asphyxia is an insult to the newborn due to lack of oxygen, lack of perfusion to various organs which results in multiorgan system dysfunction due to hypoxic damage mainly on brain, lung, liver and intraventricular haemorrhage which affect the bilirubin conjugation ability of the liver that results in jaundice.…”

Section: Discussionmentioning

confidence: 96%

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Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

Demis

Alemnew

Getie

et al. 2020

bmjpo

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BackgroundNeonatal jaundice is associated with a significant risk of neonatal morbidity and mortality. It is a major cause of hospital neonatal intensive care unit admission and readmissions during the neonatal period. Hence, the study aimed to identify the determinant factors of neonatal jaundice among neonates admitted at five referral hospitals in Amhara region, Northern Ethiopia.MethodA hospital-based unmatched case-control study design was employed, on 447 neonates (149 cases and 298 controls) at referral hospitals in Amhara region, Northern Ethiopia, from 1 March to 30 July 2019. Consecutive sampling method was used to select both the cases and controls. The collected data were entered into Epi data V.4.2 and then exported into SPSS window V.24 for analysis. Bivariable and multivariable analysis were carried out by using binary logistic regression. A p value of <0.05 was considered as significant difference between cases and controls for the exposure variable of interest.ResultsThe median (±IQR) age of neonate at the time of admission and gestational age were 3±2 days and 38 (±3) weeks, respectively. Prolonged duration of labour (adjusted OR (AOR)=2.45, 95% CI 1.34 to 4.47), being male sex (AOR=3.54, 95% CI 1.99 to 6.29), low birth weight (AOR=5.06, 95% CI 2.61 to 9.82), birth asphyxia (AOR=2.88, 95% CI 1.38 to 5.99), sepsis (AOR=2.49, 95% CI 1.22 to 5.11) and hypothermia (AOR=2.88, 95% CI 2.63 to 14.02) were the determinant factors for neonatal jaundice.ConclusionsProlonged duration of labour, hypothermia, sepsis, birth asphyxia, low birth weight and sex of neonate were independent determinants of neonatal jaundice. Early recognition and management of identified modifiable determinants are the recommended interventions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

Demis

Alemnew

Getie

et al. 2020

bmjpo

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“…Most of neonates with jaundice had low birth weight compared to those without jaundice. This is comparable to the findings of a study conducted in Southern Nigeria [ 13 ]. Our study also confirmed an earlier observation by Menon and Amanullah [ 14 ] and Devi and Vijaykumar [ 15 ] which associated neonatal jaundice with low neonatal birth weight in India.…”

Section: Discussionsupporting

confidence: 90%

Knowledge Level and Determinants of Neonatal Jaundice: A Cross-Sectional Study in the Effutu Municipality of Ghana

Adoba

Ephraim

Kontor

et al. 2018

International Journal of Pediatrics

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Background Neonatal jaundice (NNJ) is a major cause of hospital admission during the neonatal period and is associated with significant mortality. This case-control study with cross-sectional design sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition. Methods One hundred and fifty (150) neonates comprising 100 with clinically evident jaundice and 50 without jaundice were conveniently recruited from the Trauma and Specialist Hospital in the Effutu Municipality. Blood samples were collected for the determination of serum bilirubin, glucose-6-phosphate dehydrogenase (G6PD), status and blood group (ABO and Rhesus). Well-structured questionnaire was used to collect maternal and neonate sociodemographic and clinical history. Results Majority (54%) of neonates developed jaundice within 1–3 days after birth with 10% having it at birth. Duration of labour and neonatal birth weight were associated with neonatal jaundice (P < 0.05). G6PD abnormality was found in 11 (12%) of the neonates with jaundice and ABO incompatibility was present in 18%. Neonates delivered by mothers with formal occupation and those who had prolonged duration of labour were significantly more likely to have neonatal jaundice (OR = 4.174, P = 0.003; OR = 2.389, P = 0.025, resp.). Neonates with low birth weight were also more likely to develop neonatal jaundice (OR = 2.347, P = 0.044). Only 17.3% of mothers had heard of neonatal jaundice. School was the major source of information on neonatal jaundice (34.6%). Majority of participants (mothers) did not know that NNJ can cause damage to other organs in the body (90%). Conclusion Low neonatal birth weight and prolonged duration of labour are associated with neonatal jaundice. Mothers had inadequate knowledge of neonatal jaundice and its causes.

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“…However, it was lower than finding from Shimla India (64%) [22]. On the other hand, this result was higher than the findings from Osijek Croatia (24.8 %) [23], Tehran (12.6 %) [5], Southern Nepal (2.93%) [16], Egypt (16.6%) [24], Lagos Nigeria (6.7%) [25], Benin City (26.5%) [17], Niger Delta University Teaching Hospital Nigeria (17.9%) [26], and Ethiopia (26.45%) [27]. The difference could be due to variation in study setting, time, and design among different studies.…”

Section: Discussionmentioning

confidence: 76%

“…The odds of developing neonatal jaundice among neonates who had sepsis were about two times higher compared with those neonates who had no sepsis diagnosis. Sepsis was also identified as the possible causes of neonatal jaundice in studies conducted in India [22, 32, 33], Iran [34, 35], and Nigeria [15, 26]. This might be due to the fact that sepsis might cause hemolysis of red blood cells and hepatic dysfunction that leads to accumulation of serum bilirubin in the body [36, 37].…”

Section: Discussionmentioning

confidence: 99%

Magnitude of Neonatal Jaundice and Its Associated Factor in Neonatal Intensive Care Units of Mekelle City Public Hospitals, Northern Ethiopia

Lake

Abera

Azeze

et al. 2019

International Journal of Pediatrics

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Background. Jaundice in the neonate is one of the most common clinical problems. Globally, every year about 1.1 million babies develop it and the vast majority reside in sub-Saharan Africa and South Asia. Study on magnitude and local factors associated with neonatal jaundice is limited in Ethiopia. So this study was aimed at assessing magnitude and predictors of neonatal jaundice among neonates admitted to neonatal intensive care unit of public hospitals in Mekelle city, Northern Ethiopia. Methods. Institution based cross-sectional study was conducted from February to April 2016 in neonatal intensive care unit of Mekelle city public hospitals. Systematic random sampling technique was used to select study participants. Data was collected by interviewing mothers through structured questionnaire and reviewing neonates’ medical records using checklist. Multivariable binary logistic regression analyses were employed to identify factors associated with neonatal jaundice. Results. A total of 209 neonates with their mothers were included. The proportion of neonatal jaundice was found to be 37.3%. Prolonged labor [AOR = 4.39; 95% CI (1.8-10.69)], being male [AOR = 3.7; 95% CI (1.54-8.87)], maternal “O” blood group [AOR = 5.05; 95% CI (1.53-16.72)], sepsis [AOR = 2.64; 95% CI (1.15-6.05)], and blood type incompatibility [AOR = 18.21; 95% CI (6.36-52.13)] were positively associated with neonatal jaundice while night time delivery [AOR 0.42; 95% CI (0.18-0.96)] showed negative association. Conclusion. The magnitude of neonatal jaundice among neonates was found to be high. Duration of labor, time of delivery, sexes of neonate, sepsis, maternal blood group, and blood type incompatibility were significantly associated with neonatal jaundice. Therefore, improving newborn care and timely intervention for neonates with ABO/Rh incompatibility are recommended.

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Survey and Management Outcome of Neonatal Jaundice from a Developing Tertiary Health Centre, Southern Nigeria.

Cited by 13 publications

References 3 publications

Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

Knowledge Level and Determinants of Neonatal Jaundice: A Cross-Sectional Study in the Effutu Municipality of Ghana

Magnitude of Neonatal Jaundice and Its Associated Factor in Neonatal Intensive Care Units of Mekelle City Public Hospitals, Northern Ethiopia

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