Magnitude of Neonatal Jaundice and Its Associated Factor in Neonatal Intensive Care Units of Mekelle City Public Hospitals, Northern Ethiopia

Lake, Eyasu Alem; Abera, Gerezgiher Buruh; Azeze, Gedion Asnake; Gebeyew, Natnaeal A.; Demissie, Birhanu Wondimeneh

doi:10.1155/2019/1054943

Cited by 32 publications

(62 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood type incompatibility was another contributing factor for neonatal hyperbilirubinemia and their connection was reported in five studies included in our analyses (6,7,(9)(10)(11) . The pooled odds ratio was 3.3 (95% CI: 1.96, 5.72), suggesting that the risk of developing hyperbilirubinemia was 3.3 times higher among neonates with an incompatible blood type as compared to blood type-compatible infants (Figure 8).…”

Section: The Association Between Blood Type Incompatibility and Neonamentioning

confidence: 71%

“…The prevalence of hyperbilirubinemia in the neonates of sub-Saharan Africa is somewhat inconsistent in the current literature, with rates ranging from 4-45.8% (4)(5)(6)(7). That said, the burden of this condition on medical systems in developed and developing nations is significant (1).…”

Section: Introductionmentioning

confidence: 95%

“…The minimum sample size was 91 participants in a study conducted at Awolowo University, Nigeria (16), while the largest sample size was 5229 participants from Nigeria (11). All studies involved populations from sub-Saharan Africa, with six involving participants from Nigeria (6,8,10,11,16,17), two from Ethiopia (7,9), and one each from Zimbabwe (5), and Congo (4). Regarding the sampling technique employed, six of the studies (7-9, 16-18) used consecutive sampling to select study participants.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…That said, the burden of this condition on medical systems in developed and developing nations is significant (1). There are many risk factors that can predispose infants to hyperbilirubinemia, including jaundice observed in the first 24 hours, blood group incompatibility, other known hemolytic disease, elevated end-tidal carbon dioxide, gestational age of 35-36 weeks, sibling received phototherapy, cephalohematoma, significant bruising, excessive weight loss, isoimmune hemolytic disease, glucose-6-phosphate dehydrogenase (G6PD) deficiency, asphyxia, temperature instability, sepsis, acidosis, and albumin < 3 g/dl (2,7,8). More than any other risk factors, G6PD deficiency and blood group incompatibility are the most significant contributing causes for neurotoxicity (2).…”

Section: Introductionmentioning

confidence: 99%

“…Although G6PD deficiency and blood group incompatibility are widely regarded as risk factors for hyperbilirubinemia, the literature does show some inconsistencies (7)(8)(9)(10)(11)(12)(13)(14). For instance, several studies from sub-Saharan African countries (7,(9)(10)(11) have indicated that G6PD deficiency and blood incompatibility are associated with an increased risk of neonatal jaundice. However, another study showed that they were not associated with jaundice (12).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

Aynalem

Mulu

Akalu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Severe indirect hyperbilirubinemia is a silent cause of newborn disease and death worldwide. However, studies of the disease in sub-Saharan Africa are highly variable with respect to its prevalence. Hence, this study aimed to estimate the overall magnitude of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase (GP6D) deficiency and blood type incompatibility in sub-Saharan Africa.Methods: PubMed, Scopus, Google Scholar, and the Cochrane Review were systematically searched online to retrieve hyperbilirubinemia-related articles. All observational studies reported the prevalence of hyperbilirubinemia in sub-Saharan Africa were included for analysis and excluded if the study failed to determine the desired outcome. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed. Heterogeneity across the included studies was evaluated using the inconsistency index (I2). Publication bias was examined by funnel plot and the Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of neonatal hyperbilirubinemia among patients in Sub Saharan Africa. The meta-analysis was performed using the STATA™ version 14 software.Results: A total of 30,486 studies were collected from the different databases and 10 articles were included for the final analysis. The overall magnitude of neonatal hyperbilirubinemia was 28.08 % (95% CI: (20.23, 35.94)) in sub-Saharan Africa. Neonates with G6PD deficiency were 2.42 times (95% CI: 1.64, 3.56) more likely to develop hyperbilirubinemia as compared to infants with normal G6PD levels. Moreover, the risk of developing hyperbilirubinemia was 3.3 times (95% CI: 1.96, 5.72) higher among neonates that had a blood type that was incompatible with their mother’s.Conclusion: The failure to prevent and screen G6PD deficiency and blood type incompatibility with their mother’s results in high burden of neonatal hyperbilirubinemia in sub-Saharan Africa. Therefore, early identification and care strategies should be developed to the affected neonates with G6PD deficiency and blood type incompatibility with their mother’s to address long-term medical and scholastic damages among those exposed to severe hyperbilirubinemia

show abstract