Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions

Hollander, Wouter J. den; Holster, Ingrid L.; Hoed, Caroline M. den; Capelle, Lisette; Tang, Tjon J.; Anten, Marie-Paule; Prytz-Berset, Ingrid; Witteman, E. M.; Borg, Frank ter; Hartog, G. den; Bruno, Marco J.; Peppelenbosch, Maikel P.; Lesterhuis, Wilco; Doukas, Michael; Kuipers, Ernst J.; Spaander, Manon C.W.

doi:10.1136/gutjnl-2017-314498

Cited by 106 publications

(76 citation statements)

References 26 publications

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“…In western countries, despite the decrease in H. pylori prevalence observed among younger generations, H. pylori is responsible for half the burden of all infection‐related cancers 4 . Although incidence rates of gastric cancer are low in most developed countries, 6 mortality rates are high as cancer cases are usually diagnosed at a late stage 7 . Furthermore, the risk of noncardia gastric cancer has been shown to be significantly elevated among migrant populations 8 .…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study

et al. 2020

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Background: Helicobacter pylori prevalence varies greatly worldwide. We explored the prevalence of H. pylori and CagA seropositivity among adults aged 18-44 years living in the Netherlands by ethnicity and migration status (first vs second generation). Materials and Methods:Participants from six different ethnic groups were selected from the population-based multi-ethnic HELIUS study in Amsterdam, the Netherlands. Serum samples were tested for H. pylori antigens using a validated Luminex-based multiplex serology assay. Prevalence ratios were estimated using Poisson regression analysis. Results:A total of 4683 participants aged 18-44 years were randomly selected based on sex, ethnicity, and age. H. pylori seroprevalence was highest in the Ghanaian group (84%), followed by Moroccan (81%), Turkish (66%), African Surinamese (51%), South-Asian Surinamese (48%), and Dutch (17%) participants. All ethnic minority groups had a significantly higher risk of being H. pylori seropositive compared to the Dutch group.This association was strongest among participants born outside the Netherlands (first generation), but was still significant and apparent among second-generation participants. Among first-generation participants, all groups, except the Moroccans, had a significantly higher proportion of individuals with a cagA + H. pylori strain compared to the Dutch participants. Conclusion:Helicobacter pylori seroprevalence among first-generation migrants is high in the Netherlands and remains elevated among second-generation migrants (ie, those born in the Netherlands). High exposure to H. pylori, and especially to the more virulent cagA+ strain, highlights the need for tailored prevention of gastric diseases (notably peptic ulcers and cancers) among migrants. K E Y W O R D Scross-sectional study, ethnicity, general population, Helicobacter pylori, migrants, seroprevalence 2 of 14 | ALBERTS ET AL. | INTRODUC TI ONThe bacterium Helicobacter pylori has been identified as a strong risk factor for severe diseases, including peptic ulcer disease, noncardia gastric cancer, and gastric lymphoma. 1-3 H. pylori is the most impactful infectious agent causing cancer worldwide, that is, 810 000 (37%) of the 2.2 million cancers attributable to infectious diseases in the year 2018. 4,5 In western countries, despite the decrease in H. pylori prevalence observed among younger generations, H. pylori is responsible for half the burden of all infection-related cancers. 4 Although incidence rates of gastric cancer are low in most developed countries, 6 mortality rates are high as cancer cases are usually diagnosed at a late stage. 7 Furthermore, the risk of noncardia gastric cancer has been shown to be significantly elevated among migrant populations. 8 H. pylori can be effectively treated using a combination of antimicrobial drugs given orally for 7-14 days. 9 No worldwide consensus currently exists on testing and treatment of H. pylori to prevent the burden of diseases caused by this chronic infection. 10,11 To be able to make projections on futu...

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Section: Introductionmentioning

confidence: 99%

Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study

et al. 2020

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“…In a prospective cohort study on 68 patients at risk of OSCC secondary to a previous head and neck neoplasia, the per-patient sensitivity, specificity, positive and negative predictive values were 63%, 86%, 77% and 76%, compared to conventional gastroscopy. These values have dropped down to 61%, 86%, 77% and 73%, respectively, compared to endoscopy with Lugol staining (Heresbach et al, 2010).…”

Section: Capsule Endoscopymentioning

confidence: 84%

“…A recent multicentre prospective cohort study from the Netherlands and Norway showed that the serological panel (pepsinogen and G‐17) might add additional value in stratifying patients with premalignant conditions of the stomach to those at higher and lower risk for malignant progression (den Hollander et al ., ). Such stratification could lead to a reduction of unnecessary endoscopic surveillance in a large group of patients with a low‐risk profile.…”

Section: Technologies For Early Diagnosismentioning

confidence: 97%

Early detection and therapeutics

Januszewicz

Fitzgerald

2019

Molecular Oncology

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Early detection, including cancer screening and surveillance, is emerging as one of the most important topics in modern oncology. Because symptomatic presentation remains the predominant route to cancer diagnosis, there is a growing interest in developing techniques to detect the disease at an early, curative stage. Moreover, growing understanding of cancer biology has paved the way for prevention studies with the focus on therapeutic interventions for premalignant conditions. Where there is a recognisable precursor stage, such as a colorectal adenoma or Barrett's metaplasia, the removal of abnormal tissue prevents the development of cancer and enables stratification of the patient to a high‐risk group requiring further surveillance. Here, we provide a review of the available technologies for early diagnosis and minimally‐invasive treatment.

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“…Eine landesweite Kohortenstudie aus den Niederlanden an über 90 000 Patienten zeigte 2008, dass die jährliche Inzidenz für das Magenkarzinom im Falle einer atrophischen Gastritis bei ca. 0,1 % liegt, bei Vorliegen von IM bei 0,25 %, bei niedrig-und mäßiggradiger Dysplasie bei 0,6 % und bei hochgradiger Dysplasie bei 6 [10,11].…”

Section: Hintergrundunclassified

Aufruf zur endoskopischen Überwachung fortgeschrittener präneoplastischer Läsionen des Magens

2019

Gastroenterologie up2date

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Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions

Abstract: In a low gastric cancer incidence area, a surveillance programme can detect gastric cancer at an early curable stage with an overall risk of neoplastic progression of 0.3% per year. Use of serological markers in endoscopic surveillance programmes may improve risk stratification.

Cited by 106 publications

References 26 publications

Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study

Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study

Early detection and therapeutics

Aufruf zur endoskopischen Überwachung fortgeschrittener präneoplastischer Läsionen des Magens

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