Surveillance of Japanese Encephalitis Virus Infection in Mosquitoes in Vietnam from 2006 to 2008

Kuwata, Ryusei; Nga, Phan Thi; Yến, Nguyễn Thị; Hoshino, Kazuki; Isawa, Haruhiko; Higa, Yukiko; Hoang, Nguyen Vet; Trang, Bui Minh; Phuong, Loan; Phong, Trần Vũ; Sasaki, Toshinori; Tsuda, Yuichi; Kobayashi, Mutsuo; Sawabe, Kyoko; Takagi, Masahiro

doi:10.4269/ajtmh.12-0407

Cited by 33 publications

(32 citation statements)

References 48 publications

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“…These observations suggest that genotype 1 has replaced genotype 3 and has become the prevalent genotype of JEV in the area, consistent with other results demonstrating the emergence of genotype 1 JEV as the dominant genotype found in Asia [50,51]. Some authors proposed that genotype 1 JEV originated in Southeast Asia [52-54]. In that case, this genotype was likely introduced into Yunnan Province and other areas of China in the past decade.…”

Section: Discussionsupporting

confidence: 88%

Mosquitoes of Western Yunnan Province, China: Seasonal Abundance, Diversity, and Arbovirus Associations

Zhang

Yang

et al. 2013

PLoS ONE

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ObjectiveThe western borderland between Yunnan Province, China, and Myanmar is characterized by a climate that facilitates year-round production of mosquitoes. Numerous mosquito-transmitted viruses, including Japanese encephalitis virus circulate in this area. This project was to describe seasonal patterns in mosquito species abundance and arbovirus activity in the mosquito populations.MethodsMosquitoes were collected in Mangshi and Ruili cities of Dehong Prefecture near the border of China and Burma in Yunnan Province, the Peoples Republic of China in 2010. We monitored mosquito species abundance for a 12-month period using ultraviolet light, carbon dioxide baited CDC light and gravid traps; and tested the captured mosquitoes for the presence of virus to evaluate mosquito-virus associations in rural/agricultural settings in the area.ResultsA total of 43 species of mosquitoes from seven genera were collected, including 15 Culex species, 15 Anopheles spp., four Aedes spp., three Armigeres spp., one Mimomyia spp., two Uranotaenia spp. and three Mansonia spp.. Species richness and diversity varied between Mangshi and Ruili. Culex tritaeniorhynchus, Culex quinquefasciatus, Anopheles sinensis and Anopheles peditaeniatus were the most abundant species in both sampling sites. Ultraviolet light traps collected more specimens than CDC light traps baited with dry ice, though both collected the same variety of mosquito species. The CDC gravid trap was the most effective trap for capture of Culex quinquefasciatus, a species underrepresented in light trap collections. A total of 26 virus strains were isolated, which included 13 strains of Japanese encephalitis virus, four strains of Getah virus, one strain of Oya virus, one strain from the orbivirus genus, and seven strains of Culex pipien pallens densovirus.ConclusionsThe present study illustrates the value of monitoring mosquito populations and mosquito-transmitted viruses year-round in areas where the climate supports year-round adult mosquito activity.

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Section: Discussionsupporting

confidence: 88%

Mosquitoes of Western Yunnan Province, China: Seasonal Abundance, Diversity, and Arbovirus Associations

Zhang

Yang

et al. 2013

PLoS ONE

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“…The improved vaccine was introduced into the routine immunization program in Japan in 1967, when > 1000 cases per year occurred, and the number of reported cases has since decreased markedly, with < 10 cases reported annually since 1992 [78]. Similar trends have been observed in China [79], Korea [80,81], Malaysia [82], Nepal [83], Sri Lanka [84], Taiwan [85], Thailand [86,87] and Vietnam [88]. These observations clearly indicate that JE is a vaccinepreventable infectious disease.…”

Section: Vaccinessupporting

confidence: 65%

Potential chemotherapeutic targets for Japanese encephalitis: current status of antiviral drug development and future challenges

Ishikawa

Konishi

2015

Expert Opinion on Therapeutic Targets

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Although the development of effective anti-JE drugs is an urgent issue, only supportive care is currently available. Recent progress in our understanding of the viral replication machinery and immune evasion strategies has identified new targets for anti-JE drug development. To date, most candidate drugs have only been evaluated in single-drug formulations, and efficient drug delivery to the CNS has virtually not been considered. However, an effective anti-JE treatment is expected to be achieved with multiple-drug formulations and a targeted drug delivery system in the near future.

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“…Female mosquitoes of the species C. tritaeniorhynchus were captured in Dak Nong Province in the highlands of Vietnam in July 2007 [11]. Collected mosquitoes were sorted into pools and kept frozen at -80°C.…”

Section: Mosquito Collectionmentioning

confidence: 99%

Characterization of Dak Nong virus, an insect nidovirus isolated from Culex mosquitoes in Vietnam

et al. 2013

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In this study, we isolated and characterized an insect nidovirus from the mosquito Culex tritaeniorhynchus Giles (Diptera: Culicidae) in Vietnam, as an additional member of the new family Mesoniviridae in the order Nidovirales. The virus, designated "Dak Nong virus (DKNV)," shared many characteristics with Cavally virus and Nam Dinh virus, which have also been discovered recently in mosquitoes, and these viruses should be considered members of a single virus species, Alphamesonivirus 1. DKNV grew in cultured mosquito cells but could not replicate in the cultured vertebrate cells tested. N-terminal sequencing of the DKNV structural proteins revealed two posttranslational cleavage sites in the spike glycoprotein precursor. DKNV is assumed to be a new member of the species Alphamesonivirus 1, and the current study provides further understanding of viruses belonging to the new family Mesoniviridae.

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Surveillance of Japanese Encephalitis Virus Infection in Mosquitoes in Vietnam from 2006 to 2008

Cited by 33 publications

References 48 publications

Mosquitoes of Western Yunnan Province, China: Seasonal Abundance, Diversity, and Arbovirus Associations

Mosquitoes of Western Yunnan Province, China: Seasonal Abundance, Diversity, and Arbovirus Associations

Potential chemotherapeutic targets for Japanese encephalitis: current status of antiviral drug development and future challenges

Characterization of Dak Nong virus, an insect nidovirus isolated from Culex mosquitoes in Vietnam

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