Surveillance of antimicrobial resistance among Gram-negative isolates from intensive care units in eight hospitals in Turkey

Aksaray, Sebahat; Dokuzoğuz, Başak; Güvener, Engin; Yücesoy, Mine; Yuluğ, Nuran; Kocagöz, Sesin; Ünal, Sevim; Çetin, Sıla; Çalangu, Semra; Günaydın, Murat; Leblebicioğlu, Hakan; Esen, Şaban; Bayar, Banu; Willke, Ayşe; Fındık, Duygu; Tuncer, İnci; Baysal, Bülent; Günseren, Filiz; Mamikoglu, Latife

doi:10.1093/jac/45.5.695

Cited by 45 publications

(16 citation statements)

References 8 publications

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“…Furthermore, antimicrobial resistance among Pseudomonas species is increasing. Surprisingly, carbapenem susceptibility rates among P. aeruginosa isolates in this study were higher than those in previous national studies (71z versus 48-64z, respectively) (13,14). However, these findings may vary according to ICU and patient profiles.…”

Section: Discussioncontrasting

confidence: 89%

Healthcare-Associated Infections in Pediatric Intensive Care Units in Turkey: a National Point-Prevalence Survey

et al. 2015

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SUMMARY: Health care-associated infections (HCAIs) cause considerable morbidity and mortality in pediatric intensive care units (PICUs). The objective of this point prevalence study was to assess the burden of HCAIs in PICUs in Turkey. Fifty PICUs participated in this study. Data regarding demographics, microbiological findings, therapeutic interventions, and outcomes were collected for all PICU inpatients. A total of 327 patients participated in the study: 122 (37z) experienced 1 or more HCAI. The most frequently reported site of infection was lower respiratory tract (n＝77, 63z). The most frequently isolated pathogens were Pseudomonas aeruginosa, Acinetobacter species, and Candida species. Two hundred and forty-seven patients (75z) were receiving antimicrobial therapy at the time of the survey, and the most frequently administered antimicrobials were third generation cephalosporins. Hospital type, male, PICU stay ＞7 days, and mechanical ventilation were found to be independent risk factors for HCAIs. At the 4-week follow up, 43 (13z) patients had died, 28 (65z) of whom died of HCAIs. Endotracheal intubation, urinary catheter, male, and HCAIs were independent risk factors for mortality. This national, multicenter study documented a high prevalence of HCAIs in Turkey. In light of the`primum non nocere' principle, the prevention of these infections should be a priority of public health policy.

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Section: Discussioncontrasting

confidence: 89%

Healthcare-Associated Infections in Pediatric Intensive Care Units in Turkey: a National Point-Prevalence Survey

et al. 2015

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“…30% in Italy and the UK and 35% in Turkey [6]. In various studies from Turkey performed in ICUs, carbapenem resistance in A. baumannii was reported to be between 55% and 63% [5,7].…”

Section: Discussionmentioning

confidence: 99%

Colistin and tigecycline susceptibility among multidrug-resistant Acinetobacter baumannii isolated from ventilator-associated pneumonia

Dizbay¹,

Altunçekiç²,

Sezer³

et al. 2008

International Journal of Antimicrobial Agents

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“…The overall carbapenem susceptibility rate was 63% among Pseudomonas aeruginosa isolates in this study. The carbapenem susceptibility rate has been reported to be between 48% and 71% in previous national studies [1,2,21,22]. Acinetobacter infection rates in PICUs are also increasing due to resistance to commonly used broad-spectrum antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Healthcare-associated infections in a newly opened pediatric intensive care unit in Turkey: Results of four-year surveillance

Atıcı

Soysal

Kadayıfçı

et al. 2016

J Infect Dev Ctries

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Introduction: Healthcare-associated infections (HAIs) are important causes of morbidity and mortality, especially in critically ill patients in intensive care units. The aim of this study was to assess the rate and distribution of HAIs, pathogens, and antimicrobial susceptibility patterns in a newly opened pediatric intensive care unit (PICU). Methodology: The infection control team detected and recorded HAI cases according to the Centers for Disease Control and Prevention's criteria in the PICU of Marmara University Pendik Training and Research Hospital over a four-year period following its opening. Laboratorybased HAIs surveillance was performed prospectively from 1 January 2011 to 30 November 2014. Results: During the study period, 1,007 patients hospitalized in the PICU and 224 HAIs were identified. The overall HAI rate was 22.24%, and the incidence density was 20.71 per 1,000 patient-days. The most commonly observed HAIs were bloodstream infection (35.7%), pneumonia (21.4%), and urinary tract infection (20.5%), and the three most common HAI pathogens were Klebsiella spp. (19.4%), Pseudomonas aeruginosa (13.8%), and Acinetobacter baumanii (12%). Methicillin resistance was detected in 78% of coagulase-negative Staphylococcus. Presence of extended-spectrum beta-lactamases was determined in 45% and 54% of Klebsiella spp. strains and Escherichia coli isolates, respectively. Conclusions: Our rate of HAIs is higher than the mean rates reported in PICU studies from developed countries. Active surveillance studies of HAIs is an essential component of infection control, which may contribute to improving preventive strategies in developing countries.

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Surveillance of antimicrobial resistance among Gram-negative isolates from intensive care units in eight hospitals in Turkey

Cited by 45 publications

References 8 publications

Healthcare-Associated Infections in Pediatric Intensive Care Units in Turkey: a National Point-Prevalence Survey

Healthcare-Associated Infections in Pediatric Intensive Care Units in Turkey: a National Point-Prevalence Survey

Colistin and tigecycline susceptibility among multidrug-resistant Acinetobacter baumannii isolated from ventilator-associated pneumonia

Healthcare-associated infections in a newly opened pediatric intensive care unit in Turkey: Results of four-year surveillance

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