Colistin and tigecycline susceptibility among multidrug-resistant Acinetobacter baumannii isolated from ventilator-associated pneumonia

Dizbay, Murat; Altunçekiç, Arzu; Sezer, Büşra Ergüt; Özdemir, Kevser; Arman, Dilek

doi:10.1016/j.ijantimicag.2008.02.016

Cited by 53 publications

(39 citation statements)

References 18 publications

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“…Furthermore, tigecycline and colistin resistance rates of A. baumannii strains isolated in Germany were 6% and 2.8%, respectively (21) . A study in Turkey reported considerably higher tigecycline resistance rates (25%) of Acinetobacter strains (22) .…”

Section: Discussionmentioning

confidence: 96%

Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management

Sohail

Rashid

Aslam

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The drug resistant Acinetobacter strains are important causes of nosocomial infections that are difficult to control and treat. This study aimed to determine the antimicrobial susceptibility patterns of Acinetobacter strains isolated from different clinical specimens obtained from patients belonging to different age groups. Methods: In total, 716 non-duplicate Acinetobacter isolates were collected from the infected patients admitted to tertiary-care hospitals at Lahore, Pakistan, over a period of 28 months. The Acinetobacter isolates were identified using API 20E, and antimicrobial susceptibility testing was performed and interpreted according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: The isolation rate of Acinetobacter was high from the respiratory specimens, followed by wound samples. Antibiotic susceptibility analyses of the isolates revealed that the resistance to cefotaxime and ceftazidime was the most common, in 710 (99.2%) specimens each, followed by the resistance to gentamicin in 670 (93.6%) isolates, and to imipenem in 651 (90.9%) isolates. However, almost all isolates were susceptible to tigecycline, colistin, and polymyxin B. Conclusions: The present study showed the alarming trends of resistance of Acinetobacter strains isolated from clinical specimens to the various classes of antimicrobials. The improvement of microbiological techniques for earlier and more accurate identification of bacteria is necessary for the selection of appropriate treatments.

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Section: Discussionmentioning

confidence: 96%

Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management

Sohail

Rashid

Aslam

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…In a previous study performed in our hospital, 80.5% of A. baumannii strains isolated from VAP were determined to be MDR. 8 Some of these strains were resistant to all antibiotics except CO and TIG. As reported in a Taiwanese study, the emergence of XDR or pandrug-resistant A. baumannii strains is associated with increasing use of carbapenems and ciprofloxacin.…”

Section: Discussionmentioning

confidence: 98%

“…baumannii strains isolated from VAP were resistant to TIG. 8 Furthermore, exposure to subtherapeutic levels of TIG for even short periods of time may promote the rapid emergence of TIG resistance and cause therapeutic failure. 23 An efflux pump mechanism that confers reduced susceptibility to aminoglycosides, fluoroquinolones, erythromycin, chloramphenicol and tetracyclines is the most probable resistance mechanism for TIG in A. baumannii.…”

Section: Discussionmentioning

confidence: 99%

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In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

et al. 2009

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The emergence of extensive drug-resistant (XDR) Acinetobacter baumannii limits the therapeutic options and leads to high mortality in intensive care units. Combined antibiotic therapy is frequently recommended for the treatment of these infections. Colistin (CO) and tigecycline (TIG), alone or in combination with other antimicrobials, are the most commonly used antibiotics in the treatment of these resistant infections. In this study, the in vitro synergistic activity of TIG and CO were tested for 25 XDR-A. baumannii strains isolated from ventilator-associated pneumonia by the Etest method. Resistance to CO was not detected, whereas 8% of the strains were resistant to TIG. The TIG-CO combination was more synergistic than TIG-rifampin and CO-rifampin according to the fractional inhibitory concentration index. No antagonism was detected between the drugs in the study. There was no strong correlation between the activity of the combinations with reference to strains or genotypes. Our results suggest that the combined use of TIG and CO may be useful for the treatment of XDR-A. baumannii infections.

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“…Furthermore, both MDR and non-MDR A. baumannii isolates remained highly susceptible to colistin. Various reports from many countries, such as China, Greece, and Turkey have shown 21.5-84% of A. baumannii isolates during 1996-2009 were MDR A. baumannii and 94-100% of these isolates were susceptible to colistin 11,25,26 . Ninety-eight percent of MDR A. baumannii isolates were susceptible to colistin and had MIC 50 and MIC 90 values of 0.75 and 1 µg/ml, which were similar to those of previous studies from Dizbay 7,8,25 .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Tunyapanit¹,

Pruekprasert²,

Laoprasopwattana³

et al. 2014

ScienceAsia

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ABSTRACT:The incidence of multidrug-resistant Acinetobacter baumannii (MDR A. baumannii) is increasing worldwide and is leading to therapeutic problems. We investigated the in vitro activities of cefoperazone/sulbactam, colistin, imipenem, and rifampicin alone and in double combinations against 100 A. baumannii isolates from patients at Songklanagarind Hospital in Songkhla Province, Thailand. The E-test method was used to determine antimicrobial susceptibility, the minimal inhibitory concentration (MIC) and for antimicrobial combination testing. A. baumannii isolates were susceptible to colistin (97%), cefoperazone/sulbactam (69%), imipenem (45%), and rifampicin (13%). Fifty-nine percent of them were MDR A. baumannii. Colistin was superior to cefoperazone/sulbactam, rifampicin and imipenem against MDR A. baumannii and the MIC50, MIC90 of colistin were 0.75 and 1 µg/ml, respectively. Non-MDR A. baumannii isolates were susceptible to cefoperazone/sulbactam (100%), colistin (95%), imipenem (93%) and rifampicin (2%). Combinations of cefoperazone/sulbactam plus colistin or rifampicin, imipenem plus colistin or rifampicin and colistin plus rifampicin showed indifferent effects against most MDR isolates. Of all the antimicrobial combinations tested, cefoperazone/sulbactam plus rifampicin produced the highest percentages (42%) of synergy, partial synergy, and additive results. The activity rate of cefoperazone/sulbactam against MDR A. baumannii was higher when combined with rifampicin than colistin. Thus colistin had the greatest activity against most MDR and non-MDR A. baumannii isolates among all of the antibiotics tested. Cefoperazone/sulbactam and imipenem showed good activity against non-MDR isolates, and cefoperazone/sulbactam combined with rifampicin may be useful in treating infections caused by MDR isolates.

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Colistin and tigecycline susceptibility among multidrug-resistant Acinetobacter baumannii isolated from ventilator-associated pneumonia

Cited by 53 publications

References 18 publications

Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management

Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management

In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

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