Surprise within a meningioma: case report of signet ring cell carcinoma metastasis in a meningioma

How, Elena; Lee, Richard; Kasem, Kais; Withers, Teresa

doi:10.1111/ans.13045

Cited by 4 publications

(1 citation statement)

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“…[242528] Several reports suggest that they represent the majority of tumors metastasizing to extant meningiomas in the leptomeninges. [2468111517202227] The mechanisms underlying this this tumor-to tumor metasatases are not known. Identifying these factors may facilitate the development of therapies for these metastases.…”

Section: Introductionmentioning

confidence: 99%

Do mesothelin/MUC16 interactions facilitate adenocarcinoma metastases to intracranial meningiomas?

Johnson

2016

Surg Neurol Int

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Background:Meningiomas have been shown to express mesothelin, a high affinity binding site for MUC16, a transmembrane protein on adenocarcinoma cells. The mechanisms underlying adenocarcinoma metastases to meningiomas may provide insight into tumor-to-tumor metastases and adenocarcinoma metastases to leptomeningeal cells.Methods:Two meningiomas containing metastases from adenocarcinomas were identified and evaluated immunohistochemically for the expression and localization of mesothelin and MUC16.Results:Both meningiomas show extensive mesothelin immunoreactivity, and the adenocarcinomas metastatic to the meningiomas show mesothelin and MUC16 immunoreactivity at the interface with meningioma.Conclusions:Interactions between MUC16 and/or mesothelin on the cell membrane of adenocarcinoma cells with mesothelin on meningioma cells may facilitate adenocarcinoma metastases to meningiomas and possibly the leptomeninges.

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