Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: A nationwide prospective cohort from the French Sarcoma Group

Penel, Nicolas; Cesne, Axel Le; Bonvalot, Sylvie; Giraud, Antoine; Bompas, Emmanuelle; Rios, María; Salas, Sébastien; Isambert, Nicolás; Boudou‐Rouquette, Pascaline; Honoré, Charles; Italiano, Antoîne; Ray‐Coquard, Isabelle; Piperno‐Neumann, Sophie; Gouin, F.; Bertucci, François; Ryckewaert, Thomas; Kurtz, Jean‐Emmanuel; Ducimetière, Françoise; Coindre, Jean‐Michel; Blay, Jean‐Yves

doi:10.1016/j.ejca.2017.06.017

Cited by 150 publications

(130 citation statements)

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“…Several small studies investigating systemic therapy have shown moderate benefit with NSAIDs, antiestrogen therapy, and cytotoxic chemotherapy with widely variable rates of partial imaging response in the ranges of 15% to 50% . More recently, tyrosine kinase inhibitors have been evaluated with moderate effect as well with imaging response rates of 5% to 20% at 1 year and a larger majority exhibiting progression‐free disease between 60% and 70% …”

Section: Discussionmentioning

confidence: 99%

“…19,20 More recently, tyrosine kinase inhibitors have been evaluated with moderate effect as well with imaging response rates of 5% to 20% at 1 year and a larger majority exhibiting progression-free disease between 60% and 70%. 21,22 In six patients, a curative A0 ablation was attempted, but unfortunately not initially achieved. For some lesions, it can be quite challenging to ensure the ablation zone completely covers the tumor.…”

Section: Discussionmentioning

confidence: 99%

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Percutaneous cryoablation for the treatment of extra‐abdominal desmoid tumors

Tremblay

Lea

Neilson

et al. 2019

Journal of Surgical Oncology

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Background Desmoid tumors are rare locally invasive, benign neoplasms that develop along aponeurotic structures. Current treatment is complicated by associated morbidity and high recurrence rates. Methods A retrospective, single‐institution review identified 23 patients (age: 16‐77) with extra‐abdominal desmoid tumors who received CT‐guided percutaneous cryoablation as either a first‐line (61%) or salvage (39%) treatment in 30 sessions between 2014 and 2018. Median maximal lesion diameter was 69 mm (range: 11‐209). Intent was curative in 52% and palliative in 48%. Contrast‐enhanced cross‐sectional imaging was obtained before and after treatment in addition to routine clinical follow‐up. Results Technical success was achieved in all patients. The median follow‐up was 15.4 months (3.5‐43.4). Symptomatic improvement was demonstrated in 89% of patients. At 12 months, the average change in viable volume was −80% (range −100% to + 10%) and response by modified response evaluation criteria in solid tumors (mRECIST) was CR 36%, PR 36%, and SD 28% No rapid postablation growth or track seeding was observed. Four patients underwent repeat cryoablation for either residual or recurrent disease. Two patients sustained a major procedural complication consisting of significant neuropraxia. Conclusion Cryoablation for desmoid tumors demonstrates a high degree of symptom improvement and local tumor control on early follow‐up imaging with relatively low morbidity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Percutaneous cryoablation for the treatment of extra‐abdominal desmoid tumors

Tremblay

Lea

Neilson

et al. 2019

Journal of Surgical Oncology

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“…Regarding first‐line treatment, Briand et al 32 showed the effectiveness of a “wait and see” approach to desmoid tumors. Several other studies corroborate the value of nonoperative desmoid tumor management 33‐36 . Because locally recurrent sarcoma would be treated with surgery and possible adjuvant treatment, it is critical that surgeons are aware of postresection desmoid formation and how to distinguish it from malignancy.…”

Section: Discussionmentioning

confidence: 85%

Desmoid tumor mimics local recurrence of extremity sarcoma on MRI

Sabharwal

Ahlawat

Levin

et al. 2020

Journal of Surgical Oncology

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Background and Objectives: The development of desmoid fibromatosis after tumor resection may mimic local recurrence. To our knowledge, this phenomenon has not been reported after extremity sarcoma resection. We report four cases of desmoid-type fibromatosis ("desmoid tumors") mimicking local recurrence after extremity sarcoma resection. Methods:We retrospectively reviewed the records of patients treated for extremity sarcoma by our orthopedic oncology service from 2014 to 2019 and identified four patients with biopsy-proven desmoid tumors. We extracted clinical, pathologic, radiographic, and operative data for the primary neoplasms and desmoid tumors. Results: Four patients with postresection surveillance magnetic resonance imaging suspicious for local recurrence underwent further analysis showing desmoid tumors. Patients underwent image-guided needle biopsy, with specimens demonstrating fibromatosis-type histologic characteristics. Two cases were β-catenin positive. Desmoid tumors were managed with observation. No patient had experienced local or distant recurrence of the primary tumor at a mean follow-up of 30 months after resection (range, 23-34 months); none underwent surgery for symptoms of desmoid tumors.Conclusions: Desmoid tumors should be considered part of the differential diagnosis when assessing patients with radiographic concern for postresection local recurrence of extremity bone and soft-tissue sarcoma. An image-guided needle biopsy can inform diagnosis and management. K E Y W O R D S desmoid tumor, local recurrence, magnetic resonance imaging surveillance, sarcoma, tumor resection

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“…For patients with no symptoms, mild symptoms or mild progression based on imaging, a surveillance duration of 12-24 months is may be appropriate, with symptomatic treatment as necessary such as pain management (2). In this context, one cohort study of 771 patients found no significant difference in overall survival between the surgery and nonsurgery groups (20). Two of our patients chose surveillance, which did not identify any disease progression during their follow-up.…”

Section: Surveillancementioning

confidence: 88%