Surgical use of fibrin glue-coated collagen patch for non-hemostatic indications

Sampanis, Dimitrios; Siori, Maria

doi:10.1007/s10353-016-0436-y

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…Matrix‐bound sealants are composed of a carrier such as collagen or gelatin to stimulate endogenous coagulation, with or without additional active components (fibrinogen and thrombin). Although fibrin sealant patches were originally designed to improve haemostasis during surgery, there is an increasing number of publications about their tissue‐sealing properties for indications such as tightening anastomoses in gastrointestinal surgery, and sealing air leakage in pulmonary surgery, lymphatic leakage in urology and gynaecology, and cerebrospinal fluid leakage in neurosurgery. In the majority of previous studies in pancreatic surgery, sealant patches were used to cover the pancreatic stump after distal pancreatic resection.…”

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial of the effect of a fibrin sealant patch on pancreatic fistula formation after pancreatoduodenectomy

Schindl

Függer

Götzinger

et al. 2018

British Journal of Surgery

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BackgroundThe potential for a fibrin sealant patch to reduce the risk of postoperative pancreatic fistula (POPF) remains uncertain. The aim of this study was to evaluate whether a fibrin sealant patch is able to reduce POPF in patients undergoing pancreatoduodenectomy with pancreatojejunostomy.MethodsIn this multicentre trial, patients undergoing pancreatoduodenectomy were randomized to receive either a fibrin patch (patch group) or no patch (control group), and stratified by gland texture, pancreatic duct size and neoadjuvant treatment. The primary endpoint was POPF. Secondary endpoints included complications, drain‐related factors and duration of hospital stay. Risk factors for POPF were identified by logistic regression analysis.ResultsA total of 142 patients were enrolled. Forty‐five of 71 patients (63 per cent) in the patch group and 40 of 71 (56 per cent) in the control group developed biochemical leakage or POPF (P = 0·392). Fistulas were classified as grade B or C in 16 (23 per cent) and ten (14 per cent) patients respectively (P = 0·277). There were no differences in postoperative complications (54 patients in patch group and 50 in control group; P = 0·839), drain amylase concentration (P = 0·494), time until drain removal (mean(s.d.) 11·6(1·0) versus 13·3(1·3) days; P = 0·613), fistula closure (17·6(2·2) versus 16·5(2·1) days; P = 0·740) and duration of hospital stay (22·1(2·2) versus 18·2(0·9) days; P = 0·810) between the two groups. Multivariable logistic regression analysis confirmed that obesity (odds ratio (OR) 5·28, 95 per cent c.i. 1·20 to 23·18; P = 0·027), soft gland texture (OR 9·86, 3·41 to 28·54; P < 0·001) and a small duct (OR 5·50, 1·84 to 16·44; P = 0·002) were significant risk factors for POPF. A patch did not reduce the incidence of POPF in patients at higher risk.ConclusionThe use of a fibrin sealant patch did not reduce the occurrence of POPF and complications after pancreatoduodenectomy with pancreatojejunostomy. Registration number: 2013‐000639‐29 (EudraCT register).

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Section: Discussionmentioning

confidence: 99%

Randomized clinical trial of the effect of a fibrin sealant patch on pancreatic fistula formation after pancreatoduodenectomy

Schindl

Függer

Götzinger

et al. 2018

British Journal of Surgery

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“…The studied material is boiled in distilled water for 15 min and cooled. The reaction of the obtained solution is studied with an indicator [84,85]. This method allows evaluating pH of the sample medium and anticipating the REVIEWS course and the result of biochemical reactions occurring in the macroorganism after implant introduction.…”

Section: Identification Of Chemical Propertiesmentioning

confidence: 99%

In vitro Evaluation of Performance Properties of Sponge Hemostatic Dressings (Review)

Северинов¹,

Lazarenko²,

Sotnikov³

et al. 2020

Sovrem Tehnol Med

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Dressings for restoring organ defects and/or hemostasis in the injury site are being actively applied in operational units. These dressings are used in various surgeries and are widely represented in the foreign and domestic markets of medical products. Many local implants have different levels of hemostatic activity, which requires standardization of the algorithm of choice and the methods of their study. Here the methods of studying the performance properties of hemostatic implants in vitro have been considered and evaluation criteria of their physical, chemical and organoleptic properties in vitro have been proposed. This will allow a researcher to choose optimal variants of samples for further experiments on biological models more effectively as well as to save funds, time and reduce the number of experiments in vivo.

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“…We refer the reader to other works that more extensively review the application of fibrin sealants in clinical settings, including their use as skin grafts and burn wound reconstruction, cardiovascular surgery, and abdominal surgery . It is worth mentioning that the popularity of fibrin has significantly grown with the advances in laparoscopic surgery, where tissue closure must be based on minimally invasive techniques, since the restricted space and the limited visualization make classical suturing complex …”

Section: Clinical Applicationsmentioning

confidence: 99%

Fibrin Matrices as (Injectable) Biomaterials: Formation, Clinical Use, and Molecular Engineering

Roberts

Bukhary

Leon‐Valdivieso

et al. 2019

Macromolecular Bioscience

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This review focuses on fibrin, starting from biological mechanisms (its production from fibrinogen and its enzymatic degradation), through its use as a medical device and as a biomaterial, and finally discussing the techniques used to add biological functions and/or improve its mechanical performance through its molecular engineering. Fibrin is a material of biological (human, and even patient's own) origin, injectable, adhesive, and remodellable by cells; further, it is nature's most common choice for an in situ forming, provisional matrix. Its widespread use in the clinic and in research is therefore completely unsurprising. There are, however, areas where its biomedical performance can be improved, namely achieving a better control over mechanical properties (and possibly higher modulus), slowing down degradation or incorporating cell-instructive functions (e.g., controlled delivery of growth factors).

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Surgical use of fibrin glue-coated collagen patch for non-hemostatic indications

Cited by 4 publications

References 27 publications

Randomized clinical trial of the effect of a fibrin sealant patch on pancreatic fistula formation after pancreatoduodenectomy

Randomized clinical trial of the effect of a fibrin sealant patch on pancreatic fistula formation after pancreatoduodenectomy

In vitro Evaluation of Performance Properties of Sponge Hemostatic Dressings (Review)

Fibrin Matrices as (Injectable) Biomaterials: Formation, Clinical Use, and Molecular Engineering

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