In vitro Evaluation of Performance Properties of Sponge Hemostatic Dressings (Review)

Abstract

Dressings for restoring organ defects and/or hemostasis in the injury site are being actively applied in operational units. These dressings are used in various surgeries and are widely represented in the foreign and domestic markets of medical products. Many local implants have different levels of hemostatic activity, which requires standardization of the algorithm of choice and the methods of their study. Here the methods of studying the performance properties of hemostatic implants in vitro have been considered and evaluation criteria of their physical, chemical and organoleptic properties in vitro have been proposed. This will allow a researcher to choose optimal variants of samples for further experiments on biological models more effectively as well as to save funds, time and reduce the number of experiments in vivo.

Insight into Topical Preparations for Wound Healing: Traditional and Modern Dressings

“…High adhesive properties are an absolute requirement for controlling bleeding. Additionally, the implant sponge surface adheres to the surface of the injured organ without the use of additional suture material or other techniques [55]. In contrast, the main disadvantages of sponge dressings include the following: they are mechanically unstable, may cause maceration due to their higher content of moisture, and may result in the development of microbial infections in the absence of antibiotics.…”

Application of Alginate-Based Hydrogels in Hemostasis

“…The alginate-based sponges have a porous structure that can quickly absorb a large amount of water, concentrate plasma, stimulate the accumulation of endogenous coagulation factors in the injured area, and form hydrogels as physical barriers to stanch bleeding. They are indicated for large-area hemorrhage wounds and arterial injuries [ 98 ]. However, they are improper for uncontrollable and incompressible hemorrhage.…”