Surgical Treatment of Traumatic Bifrontal Contusions: When and How?

Zhaofeng, Lu; Li, Bing; Peng, Qiao; Jiang, Jiyao

doi:10.1016/j.wneu.2016.06.021

Cited by 10 publications

(14 citation statements)

References 25 publications

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“…Wu et al (2014) [16] reported GCS pre-surgical intervention rather than on admission, with GCS 3-7 in 25 patients, GCS 8-12 in 33 patients, and GCS 13-15 in 5 patients. The remaining study [17] reported GCS 6-8 in 9 patients, GCS 9-12 in 38 patients, and GCS 13-15 in 51 patients.…”

Section: Patient Cohortmentioning

confidence: 96%

“…All included articles were retrospective studies with a particular focus on TBC patients. Geographical locations included Scotland [12], USA [9], China [4,16,17], and India [11]. Sampling periods ranged from 1 to 14.5 years, with an average of 5.6 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Sarma et al [11] reported a mean volume of bilateral contusions as 28 mL, and patients were distinguished with respect to symmetry/asymmetry of contusions, although threshold values for this distinction were not reported. The remaining study [17] reported CT on admission (98 patients) as Bspotted^contusions in 17 patients, mean contusion volume of 15.1 mL in 73 patients, and 30.2 mL in 8 patients. Method for volume quantification of TBC was unreported in both studies.…”

Section: Imaging Parametersmentioning

confidence: 99%

“…Wu et al (2014) [16] only specified postoperative care, which entailed core temperature lowering strategies, ICP control, nutritional support, and hyperbaric oxygen therapy. The remaining studies provided information on the use of hyperosmolar agents without further distinction in one study [11] and use of mannitol, furosemide, and anti-convulsant medications in another [17].…”

Section: Managementmentioning

confidence: 99%

“…Depending on whether or not contusions were symmetrical, one of the three surgical procedures was employed: BDC alone, BC with evacuation of contusions, and unilateral evacuation of frontal contusion. Finally, Zhaofeng et al (2016) [17] used a modified BDC approach in all patients. The remaining three studies evaluated all patients with TBC, with only a proportion operated on.…”

Section: Managementmentioning

confidence: 99%

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Demographics, presentation, and clinical outcomes after traumatic bifrontal contusions: a systematic review

et al. 2019

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Traumatic bifrontal contusions (TBC) form a recognised clinical entity among patients with traumatic brain injury (TBI). This study aims to systematically review current literature on demographics, management, and predictors of outcomes of patients with TBC. A multi-database literature search (PubMed, Cochrane, OVID Medline/Embase) was performed using PRISMA as a search strategy. Studies were selected by predefined selection criteria (PROSPERO: CRD42018055390), and risk of bias was assessed using an adapted form of ROBINS-I tool. Of the 275 studies yielded by the literature search, seven articles met the criteria for inclusion, all of which were level III evidence. Total cohort consisted of 468 patients; predominantly male (n = 5; 303/417 patients) with average age 44.3 years (range, 7-81). Falls (44.9%) and road traffic accidents (46.6%) were the commonest mechanisms of injury with an average presentation GCS of 9.2 (n = 3, 119 patients). GCS on admission of ≤ 13.1 and contusion volume at day 2 post-injury of ≥ 62.9cm 3 were associated with increased risk of deterioration needing surgical interventions (n = 1, 7 patients). The majority of patients underwent surgery; the average GOS was 4, at an average follow-up duration of 11.7 months (n = 6, 356 patients). The currently available evidence on the management of TBC is scarce. Larger multicentre well-designed studies are needed to further delineate the factors behind acute deterioration, the effectiveness of management options. Once in place, this can be used to develop and test an algorithmic approach to management of TBC resulting in consistently improved outcomes.

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Section: Patient Cohortmentioning

confidence: 96%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Imaging Parametersmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

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Demographics, presentation, and clinical outcomes after traumatic bifrontal contusions: a systematic review

et al. 2019

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Value of Ventricular Intracranial Pressure Monitoring for Traumatic Bifrontal Contusions

Chen¹,

Yang³

et al. 2018

World Neurosurgery

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Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin

Liang

Lü²,

Mao

et al. 2017

Cell Death Dis

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Tobacco smoke (TS) is the most important single risk factor for bladder cancer. Epithelial–mesenchymal transition (EMT) is a transdifferentiation process, involved in the initiation of TS-related cancer. Cancer stem cells (CSCs) have an essential role in the progression of many tumors including TS-related cancer. However, the molecular mechanisms of TS exposure induced urocystic EMT and acquisition of CSCs properties remains undefined. Wnt/β-catenin pathway is critical for EMT and the maintenance of CSCs. The aim of our present study was to investigate the role of Wnt/β-catenin pathway in chronic TS exposure induced urocystic EMT, stemness acquisition and the preventive effect of curcumin. Long time TS exposure induced EMT changes and the levels of CSCs’ markers were significant upregulated. Furthermore, we demonstrated that Wnt/β-catenin pathway modulated TS-triggered EMT and stemness, as evidenced by the findings that TS elevated Wnt/β-catenin activation, and that TS-mediated EMT and stemness were attenuated by Wnt/β-catenin inhibition. Treatment of curcumin reversed TS-elicited activation of Wnt/β-catenin, EMT and CSCs properties. Collectively, these data indicated the regulatory role of Wnt/β-catenin in TS-triggered urocystic EMT, acquisition of CSCs properties and the chemopreventive effect of curcumin.

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Surgical Treatment of Traumatic Bifrontal Contusions: When and How?

Cited by 10 publications

References 25 publications

Demographics, presentation, and clinical outcomes after traumatic bifrontal contusions: a systematic review

Demographics, presentation, and clinical outcomes after traumatic bifrontal contusions: a systematic review

Value of Ventricular Intracranial Pressure Monitoring for Traumatic Bifrontal Contusions

Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin

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