Surgical treatment of primary lung cancer in patients less than 40 years of age.

Shimono, T; Hayashi, Tatsurou; Kimura, Masakazu; Yada, Isao; Namikawa, S; Yuasa, Hiroshi; Kusagawa, M

doi:10.1200/jco.1994.12.5.981

Cited by 33 publications

(42 citation statements)

References 6 publications

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“…8,30) Previous studies have reported that fewer young patients present with early-stage disease. 3,6,8,9,13,[15][16][17] However, our study revealed that 31.1% of lung cancer patients younger than 50 years presented with local-stage disease, and a similar percentage of older patients presented with the same stage. As a whole, there was no significant difference between the younger and older patient groups in the stage at which patients presented.…”

Section: Discussioncontrasting

confidence: 48%

“…3-5, 10, 11, 15, 16) Table V, which includes only data from studies involving satisfactory numbers of subjects and/or that were statistically managed, shows that results of these studies have been biased by differences in the databases used and that some studies only evaluated patients who underwent surgical resection. 10,15,16) Moreover, the definition of young patients differed, with some investigators using 40 years and others using 50 years as the cut-off age. Therefore, these results should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 99%

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Lung Cancer in Patients under 50 Years Old

Tominaga¹,

Mori²,

Yokoi³

et al. 1999

Japanese Journal of Cancer Research

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A long-term retrospective study was carried out on 790 cases of lung cancer to determine if the clinicopathologic characteristics and survival rates of lung cancer patients under the age of 50 differ from those of patients 50 years of age or older at diagnosis by analyzing data on patients registered at Tochigi Cancer Center Hospital. Of the 790 patients, 77 (9.7%) were under the age of 50 at diagnosis. The percentage of women in the younger patient group was significantly higher than that in the older patient group (39.0% vs. 27.5%; P = = = =0.034). Tumor histology revealed a significant preponderance of adenocarcinomas (60 patients, 77.9%) and a paucity of squamous cell carcinomas (8 patients, 10.4%) in the younger age group (P< < < <0.001). The preponderance of adenocarcinoma was significant in both males and females (male: P = = = =0.004, female: P = = = =0.004). Smoking rates and rate of detection by cancer screening did not differ between the two age groups. Because of the paucity of smokers among the younger female patients, causes of lung cancer other than smoking should be sought in younger patients. No difference was found in the stage of the disease at presentation, treatment methods and survival rates between the two age groups. It is suggested that the prognosis for patients with lung cancer under the age of 50 is not significantly worse than for those aged 50 years or older, as has been shown by several investigators.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Lung Cancer in Patients under 50 Years Old

Tominaga¹,

Mori²,

Yokoi³

et al. 1999

Japanese Journal of Cancer Research

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“…In some studies, higher rates of adenocarcinoma have been reported in young patients and in female patients. [2,23] Some authors have reported comparable prognoses and survival rates between young and advanced age patients, [22,23] while others indicated either unfavorable [24,25] or better [8,14] prognoses and survival rates for older patients. In our study of patients aged ≤55 years and >55 years, the most frequently seen histopathological type was squamous cell carcinoma and no significant difference was found between groups in disease stage; clinical, demographic, surgical, or oncological treatment characteristics; or overall survival rate.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Numerous studies have been performed with lung cancer patients of various age groups. [6][7][8] Therefore, there are conflicting results concerning histopathological types, survival rates, and treatment characteristics with regard to young patients. [9][10][11] This study was designed to examine sociodemographic, clinical, radiological, histopathological, and survival characteristics of patients with the diagnosis of lung cancer aged ≤55 and >55 years.…”

Section: Introductionmentioning

confidence: 99%

Different characteristics in lung cancer patients between age groups under 55 and over 55 years of age?

Doğan¹

2017

South Clin Ist Euras

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Objective: The aim of this study was to investigate the sociodemographic, clinical, radiological, histopathological, and survival characteristics of lung cancer patients ≤55 years of age. Methods:The files of patients diagnosed in the clinic as lung cancer between January 2014 and December 2016 were retrospectively evaluated. These cases were divided into 2 groups: patients who were ≤55 years of age and patients >55 years of age. The clinical, radiological, and demographic findings; histopathological type and stage of cancer; treatment modalities used; and survival data were analyzed and compared.Results: A total of 323 cases, 85 (26.3%) of them aged ≤55 years and 238 (73.7%) aged >55 years, were included in the study. The stage and histopathological type of lung cancer, smoking history, gender, oncological and surgical treatment modalities used, and survival characteristics were similar in both groups (p>0.05). Conclusion:Since the 2 groups of lung cancer patients formed on the basis of the age limit of 55 years were similar in many respects, and because the number of cancer cases increases in 5-year subgroups under the age of 55 years, screening for lung cancer may be recommended for those under 55 years, especially in cases with risk factors.

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“…Consistent with our data (Table 2), it has been reported that younger patients with lung cancer typically present with an advanced stage, and have relatively short survival times (5-7). Some investi- gators have suggested that the lower occurrence of early-stage disease in younger patients may be due to an intrinsically more aggressive disease (8,9), whereas others have attributed it to the delayed diagnosis that results from a low degree of suspicion of cancer in younger patients (3,4,10). Recently, Ramalingamet al have reported that lung cancer is not an aggressive disease in younger patients, all patients should be treated according to the same therapeutic guideline (2).…”

Section: Discussionmentioning

confidence: 99%

Very Young Patient with Peculiar Squamous Cell Carcinoma of the Lung.

et al. 1999

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A 20-year-old man with squamous cell carcinoma of the lung is described. Histology of the open lung biopsy specimen revealed squamous cell carcinoma with definite keratinization. Interestingly, the tumor cells were characterized by partial expression of CD34antigen and neuroendocrine differentiation.The diagnosis was delayed in this case because of his young age. This delayed diagnosis resulted in rapid progression and short survival time. In our review of 667 cases of lung cancers at Okayama University Hospital, only 3 (0.4%) of them were under 30 years of age and also showed advanced stage and very poor prognosis. It is important to take note of lung cancer as a differential diagnosis to detect early-stage lung cancer in young patients when they present with abnormal shadow on chest radiograph. (Internal Medicine 38: 979-983, 1999)

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Surgical treatment of primary lung cancer in patients less than 40 years of age.

Abstract: Although younger patients tended to have more advanced disease, long-term survival in these patients did not differ from that of older patients.

Cited by 33 publications

References 6 publications

Lung Cancer in Patients under 50 Years Old

Lung Cancer in Patients under 50 Years Old

Different characteristics in lung cancer patients between age groups under 55 and over 55 years of age?

Very Young Patient with Peculiar Squamous Cell Carcinoma of the Lung.

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