Very Young Patient with Peculiar Squamous Cell Carcinoma of the Lung.

Emori, Yasuyuki; Kiura, Katsuyuki; Yoshino, Tadashi; Notohara, Kenji; Tsuchida, Takahiro; Yokoyama, Mamoru; Nogami, Naoyuki; Kataoka, Masao; Ueoka, Hiroshi; Harada, Mine

doi:10.2169/internalmedicine.38.979

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…The risk of lung cancer in teenage patients has been rarely discussed. There were a few case reports and case series reviewing teenage lung cancer patients presented as dyspnea or cough, with a large solid mass appeared in CT images (Polo et al 2015;Emori et al 1999;Tajiri et al 1999;Balzer et al 2018). Majority of the adenocarcinoma patients had metastatic disease at diagnosis and more than half of the patients had died at final follow-up (Balzer et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Ground glass opacity featured lung adenocarcinoma in teenagers

Zhang

et al. 2021

J Cancer Res Clin Oncol

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Introduction Ground glass opacity (GGO) nodules were found incidentally by computed tomography (CT) scan in some teenagers, which turned out to be lung cancer. The purpose of this study is to summarize the characteristics of teenage patients with GGO featured lung adenocarcinoma. Methods Patients aging from 13 to 20 who were incidentally diagnosed with lung cancer were reviewed between February 2015 to December 2020. The clinical, radiological and pathological characteristics were analyzed. Results Totally 12 patients were included. All of them were diagnosed as GGO featured lung cancer through CT scan, with no presenting symptom. The median surveillance before surgery was 5.5 months, and none of these GGO lesions enlarged or altered in the property during the surveillance. The mean tumor diameter was 0.93 ± 0.25 cm. Ten patients underwent wedge resection by video-assisted thoracoscopic surgery (VATS), 9 of which were minimally invasive adenocarcinoma (MIA) and 1 of which were invasive adenocarcinoma (IAC) in the pathological analysis. One patient underwent VATS left-upper sublobectomy, pathologically diagnosed as MIA and 1 patient underwent VATS left-upper lobectomy with systematic mediastinal lymphadenectomy, pathologically diagnosed as IAC. The median postoperative hospital stay was 3 days. All patients survived without recurrence during a median follow-up of 12.5 months. Conclusions GGO nodules could be a sign of early-stage teenage lung adenocarcinoma. We proposed a screening strategy with long intervals based on a baseline CT scan for the teenage population, and a treatment strategy for diagnosed teenage patients.

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Section: Discussionmentioning

confidence: 99%

Ground glass opacity featured lung adenocarcinoma in teenagers

Zhang

et al. 2021

J Cancer Res Clin Oncol

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“…This epidemiologic discrepancy may be due to differences in carcinogens exposure or to biologic differences such as inefficient cell cycle arrest and DNA damage accumulation or cytochrome polymorphisms [ 9 , 12 , 13 ]. Regarding the clinico-pathologic features of LC in the young population, most retrospective series with sample sizes of more than 100 patients ( Table 2 ) reported a higher proportion of women and adenocarcinoma in younger groups compared to older patients [ 3 , 4 , 6 – 11 ], but some cases of very young patients with squamous cell LC have also been reported in recent years [ 14 – 16 ]. Data on the proportion of asymptomatic patients at diagnosis in young and old groups are discordant.…”

Section: Discussionmentioning

confidence: 99%

Non-Small Cell Lung Cancer in a Very Young Woman: A Case Report and Critical Review of the Literature

et al. 2015

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Patient: Female, 19Final Diagnosis: Lung adenocarcinomaSymptoms: Chest painMedication: —Clinical Procedure: Ct scan and pet-ctSpecialty: OncologyObjective:Unusual clinical courseBackground:Lung cancer in young patients is quite uncommon; clinical presentation and outcome in this population compared to the older group are not yet well defined and data about this setting are mostly single-institutional retrospective analyses.Case Report:We report here a case of a very young woman with diagnosis of early-stage lung adenocarcinoma harboring EML4-ALK rearrangement; she underwent radical surgery and adjuvant chemotherapy according to the pathologic stage. Potential risk factors for lung cancer in our patient are discussed and clinico-pathologic features and outcomes of lung cancer in the young population compared to the elderly are reviewed through discussing studies with sample sizes larger than 100 patients.Conclusions:A wide clinical overview should be performed when lung cancer is diagnosed in a young patient. Large-population studies are required to define the molecular signature and clinical behavior of lung cancer in young patients.

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“…Most studies in patients in their twenties are limited to a handful of case reports [3][4][5]. Presenting symptoms are commonly weight loss, hemoptysis, pain, or respiratory complaints.…”

Section: Introductionmentioning

confidence: 99%

Advanced Stage Primary Lung Cancer Masquerading as Empyema in a 23-Year-Old Male

Sando¹,

Ramìrez²,

Jf³

2017

Lung Dis Treat

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Lung cancer continues to be the number one cancer killer among men and women in the United States. Smoking stands as the primary risk factor for developing lung cancer. Consequently, primary lung cancer may act differently in young adults than expected in older adults. Many young adults diagnosed with lung cancer are never smokers and otherwise healthy. Genetic driver mutations are often found in these young adults and targeted therapy is initiated. We present a case of a 23-year-old intravenous drug user found to have advanced stage lung cancer during work up of an apparent empyema.

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Very Young Patient with Peculiar Squamous Cell Carcinoma of the Lung.

Cited by 6 publications

References 13 publications

Ground glass opacity featured lung adenocarcinoma in teenagers

Ground glass opacity featured lung adenocarcinoma in teenagers

Non-Small Cell Lung Cancer in a Very Young Woman: A Case Report and Critical Review of the Literature

Advanced Stage Primary Lung Cancer Masquerading as Empyema in a 23-Year-Old Male

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