Surgical treatment of multiple ventricular septal defects using a biologic glue

Leca, F; Karam, Joseph; Vouhé, Pascal; Khoury, Wassim; Tamisier, Daniel; Bical, O; Cruz, Eduardo M. da; Thibert, M

doi:10.1016/s0022-5223(94)70458-9

Cited by 35 publications

(25 citation statements)

References 9 publications

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“…In addition, the mean diameter of any residual VSDs was significantly smaller in the TISSEEL group. TISSEEL has also been shown to be effective in repairing multiple VSDs in children, with good short‐ and long‐term results . Other reports describing TISSEEL use in major cardiac surgery include retrospective controlled studies that supported the ability of TISSEEL to reduce blood loss (assessed using chest tube outputs) during open‐heart surgery in adult and pediatric patients …”

Section: Resultsmentioning

confidence: 99%

Use of Fibrin Sealants in Cardiovascular Surgery: A Systematic Review

Rousou

2013

J Card Surg

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Background: Fibrin sealants are used for hemostasis and tissue adherence. Aim of Study: This systematic review summarizes published clinical data for fibrin sealant use in cardiovascular surgery. Methods: A literature search for the following terms was conducted using PubMed and EMBASE: (TISSEEL or Tissucol or Beriplast P or Evicel or Quixil or Crosseal or Reliseal or Fibringluraas or Bolheal or Tachosil or Vivostat or Vitagel or Artiss or ''fibrin glue'' or ''fibrin sealant'' or ''fibrin tissue adhesive'') and (cardiac or cardiovascular or vascular or heart or coronary or surgery). Case reports and series were excluded; although reports of controlled trials were preferred, uncontrolled trial data were also considered. Results: Clinical trials and chart review analyses of fibrin sealants were identified and summarized. Although clinical trial data were available for other agents, the majority of published studies examined TISSEEL. Overall, TISSEEL and other fibrin sealants showed improvements over standard of care or control groups for a variety of predefined endpoints. Safety findings are also summarized. Conclusions: Data from these studies showed that fibrin sealants were well tolerated and provided effective hemostasis in a range of cardiac and aortic surgeries.

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Section: Resultsmentioning

confidence: 99%

Use of Fibrin Sealants in Cardiovascular Surgery: A Systematic Review

Rousou

2013

J Card Surg

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“…Generally, tailored three‐dimensional (3D) tissue‐engineered scaffolds comprise natural components found in the extracellular matrix, including collagen, fibrin, hyaluronic acid, glycosaminoglycans and hydroxyapatite, and therefore have the benefit of being bio‐active and having common mechanical characteristics of native tissues. In this regard, fibrin is a substance already employed in engineering heart valves and in the surgical repair of ventricular septal defects (Leca et al , ; von Segesser et al , ). Since it was demonstrated that fibrin provides a suitable matrix for cell growth, differentiation and function (Barsotti et al , ; Rojas et al , ), fibrin is also used for the construction of cellularized scaffolds or 'patches' that are placed over the infarcted myocardium to provide optimal cell retention and implantation at the sites of injury (Amrani et al , ; Leor et al , ; Suuronen et al , ; Xing et al , ).…”

Section: Fibrin‐based Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

Fibrin, the preferred scaffold for cell transplantation after myocardial infarction? An old molecule with a new life

Roura

Gálvez‐Montón

Bayés‐Genís

2016

J Tissue Eng Regen Med

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Fibrin is a topical haemostat, sealant and tissue glue, which consists of concentrated fibrinogen and thrombin. It has broad medical and research uses. Recently, several studies have shown that engineered patches comprising mixtures of biological or synthetic materials and progenitor cells showed therapeutic promise for regenerating damaged tissues. In that context, fibrin maintains cell adherence at the site of injury, where cells are required for tissue repair, and offers a nurturing environment that protects implanted cells without interfering with their expected benefit. Here we review the past, present and future uses of fibrin, with a focus on its use as a scaffold material for cardiac repair. Fibrin patches filled with regenerative cells can be placed over the scarring myocardium; this methodology avoids many of the drawbacks of conventional cell-infusion systems. Advantages of using fibrin also include extraction from the patient's blood, an easy readjustment and implantation procedure, increase in viability and early proliferation of delivered cells, and benefits even with the patch alone. In line with this, we discuss the numerous preclinical studies that have used fibrin-cell patches, the practical issues inherent in their generation, and the necessary process of scaling-up from animal models to patients. In the light of the data presented, fibrin stands out as a valuable biomaterial for delivering cells to damaged tissue and for promoting beneficial effects. However, before the fibrin scaffold can be translated from bench to bedside, many issues must be explored further, including suboptimal survival and limited migration of the implanted cells to underlying ischaemic myocardium. Copyright © 2016 John Wiley & Sons, Ltd.

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“…have established the efficacy of topical agents as effective modalities to conserve blood. [ 78 79 80 81 82 83 ]…”

Section: Topical Hemostatic Agentsmentioning

confidence: 99%

Strategies for blood conservation in pediatric cardiac surgery

Singh

2016

Ann Card Anaesth

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Cardiac surgery accounts for the majority of blood transfusions in a hospital. Blood transfusion has been associated with complications and major adverse events after cardiac surgery. Compared to adults it is more difficult to avoid blood transfusion in children after cardiac surgery. This article takes into account the challenges and emphasizes on the various strategies that could be implemented, to conserve blood during pediatric cardiac surgery.

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Surgical treatment of multiple ventricular septal defects using a biologic glue

Cited by 35 publications

References 9 publications

Use of Fibrin Sealants in Cardiovascular Surgery: A Systematic Review

Use of Fibrin Sealants in Cardiovascular Surgery: A Systematic Review

Fibrin, the preferred scaffold for cell transplantation after myocardial infarction? An old molecule with a new life

Strategies for blood conservation in pediatric cardiac surgery

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