Surgical treatment of lung cancer invading the chest wall: results and prognostic factors

Magdeleinat, Pierre; Alifano, Marco; Benbrahem, C.; Spaggiari, Lorenzo; Porrello, Calogero; Puyo, Philippe; Levasseur, P; Regnard, Jean François

doi:10.1016/s0003-4975(00)02666-7

Cited by 91 publications

(76 citation statements)

References 20 publications

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“…In the present study, the rate of occurrence of major complications was 7.0 % (empyema, chylothorax, and postoperative bleeding), and the postoperative mortality rate was 2.3 %. According to most of previous studies, N1 or N2 disease was a significant unfavorable prognostic factor in comparison with T3N0M0 disease [8,9,[18][19][20][21][22][23]. However, in the present study, no difference in the prognosis was observed between patients with and without lymph node metastasis, likely because there were a too few patients with lymph node metastasis.…”

Section: Discussioncontrasting

confidence: 62%

“…McCaughan showed that there was no significant difference in the 5-year survival rate between the extrapleural and chest wall resections, and noted that an extrapleural resection sufficed if the cancers involved only the parietal pleura, and negative surgical margins were confirmed by intraoperative frozen section analysis [21]. On the other hand, the depth of invasion was reported to be an unfavorable prognostic factor [8,22]. Intercostal muscle or rib invasion indicated a poor prognosis, presumably because these tissues are richly supplied with blood, thereby promoting distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the 5-year survival after surgery, reported rates ranged from 25 % to 67 % [8,18,20,22]. Studies on the postoperative mortality rate have been reported to be 3.2-7.8 % [10].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics of Resected T3 Non-small Cell Lung Cancer Characterized by Parietal Pleural Invasion or Chest Wall Invasion

et al. 2012

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics of Resected T3 Non-small Cell Lung Cancer Characterized by Parietal Pleural Invasion or Chest Wall Invasion

et al. 2012

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“…По данным разных авторов, по-слеоперационные осложнения диагностируют у 20-30% больных [10], а летальность достигает 7% [2,4,6]. В связи с этим важен тщательный отбор больных для хирургиче-ского лечения и оценка прогностических факторов.…”

Section: Discussionunclassified

Results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest

Пикин¹,

Trakhtenberg²,

Ryabov³

et al. 2016

Onkol. Z. im. P.A. Gercena

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39 Опыт рабОтыВовлечение париетальной плевры, мягких тканей и/или костных структур грудной стенки у пациентов с резектабельным немелкоклеточным раком легкого (НМРЛ), по данным разных авторов, составляет 5-8% [1,2]. Результаты консервативных методов лечения этой группы больных остаются неудовлетворительными. C тех пор как F. Coleman [3] показал техническую возможность выполнения резекции грудной стенки в случае ее вовлече-ния при раке легкого, а также несколько случаев удовлет-ворительных отдаленных результатов у пациентов данной группы, было опубликовано несколько исследований, по-священных этой проблеме.В целом отдаленные результаты лечения этой группы больных остаются неудовлетворительными, что требует изучения роли различных прогностических факторов и их влияния на общую и безрецидивную выживаемость. Цель -изучение результатов хирургического лечения больных немелкоклеточным раком легкого с врастанием опухоли в грудную стенку. Материал и методы. С 1980 г. в МНиои им. П.А. Герцена проведено хирургическое лечение 68 больным немелкоклеточным раком легкого с прорастанием опухоли в грудную стенку. По данным гистологического исследования у 34 пациентов метастазов во внутригрудных лимфатических узлах не было (N0), у 9 пациентов выявлены метастазы в лимфатических узлах корня легкого или бронхопульмональной группы (N1), у 25 пациентов -в средостенных лимфа-тических узлах (N2). хирургическое лечение в объеме лобэктомии с резекцией грудной стенки выполнено у 50 больных, билобэктомия с резекцией грудной стенки -у 2, пневмонэктомия -у 16 больных. операции паллиативного характера выполнены у 7 больных. Результаты. 5-летняя выживаемость больных при N0, N1 и N2 составила соответственно 41, 18 и 7%. При паллиативном характере операции ни один пациент не пережил этот срок. Анализ прогностических факторов по-зволяет выделить наиболее значимые: состояние внутригрудных лимфатических узлов и характер выполненной операции (радикальная или паллиативная). Заключение. отдаленные результаты хирургического лечения немелкоклеточного рака легкого с прорастанием опухоли в грудную стенку при интактных лимфатических узлах удовлетворительные: более 40% пациентов переживают 5 лет наблюдения. Паллиативный характер операции и метастазы в средостенных лимфатических узлах предопределяют плохой прогноз. Objective: to study the results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest. Subjects and methods. Sixty-eight patients with non-small cell lung cancer with tumor ingrowth into the chest have been surgically treated at the P.A. herzen Moscow oncology Research institute since 1980. histological examination showed that 34 patients had no intrathoracic lymph node metastases (N 0 ), 9 had metastases in the lung root and bronchopulmonary lymph nodes (N 1 ), and 25 had those into mediastinal ones (N 2 ). Surgery as lobectomy with chest wall resection was performed in 50 patients, bilobectomy with chest wall resection in 2, and pneumonectomy in 16 patients. Palliative surgery was done in 7 patients. R...

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“…The reported 5-year survival rate after complete resection is 21% in T3N2 disease patients [48] . In case of T4 tumors with invasion of the main carina a sleeve pmeumonectomy can be considered and has become an established procedure in carefully selected patients in experienced centers [49] .…”

Section: Nsclc Stagementioning

confidence: 99%

Surgical strategies in the therapy of non-small cell lung cancer

Al-Shahrabani

Vallböhmer

Angenendt

et al. 2014

WJCO

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Lung cancer represents the leading cause of cancer mortality worldwide. Despite improvements in preoperative staging, surgical techniques, neoadjuvant/adjuvant options and postoperative care, there are still major difficulties in significantly improving survival, especially in locally advanced non-small cell lung cancer (NSCLC). To date, surgical resection is the primary mode of treatment for stage Ⅰ and Ⅱ NSCLC and has become an important component of the multimodality therapy of even more advanced disease with a curative intention. In fact, in NSCLC patients with solitary distant metastases, surgical interventions have been discussed in the last years. Accordingly, this review displays the recent surgical strategies implemented in the therapy of NSCLC patients. Key words: Non-small cell lung cancer; Multimodality therapy; Surgical techniques; Neoadjuvant/adjuvant therapy; Solitary distant metastases Core tip: Lung cancer represents the leading cause of cancer mortality worldwide. To date, surgical resection is the primary mode of treatment for stage Ⅰ and Ⅱ non-small cell lung cancer (NSCLC) and has become an important component of the multimodality therapy of even more advanced disease with a curative intention. In fact, individualized treatment options, based on clinical tumor stages, in NSCLC patients have been established in the last years that are displayed in this review.

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Surgical treatment of lung cancer invading the chest wall: results and prognostic factors

Cited by 91 publications

References 20 publications

Clinical Characteristics of Resected T3 Non-small Cell Lung Cancer Characterized by Parietal Pleural Invasion or Chest Wall Invasion

Clinical Characteristics of Resected T3 Non-small Cell Lung Cancer Characterized by Parietal Pleural Invasion or Chest Wall Invasion

Results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest

Surgical strategies in the therapy of non-small cell lung cancer

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