Surgical treatment of independent bitemporal lobe epilepsy defined by invasive recordings

Boling, Warren; Aghakhani, Yahya; Andermann, Frédérick; Sziklas, Viviane; Olivier, André

doi:10.1136/jnnp.2008.155291

Cited by 46 publications

(42 citation statements)

References 33 publications

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“…However, on a descriptive level, the surgical group reported a slightly better subjective outcome on most questionnaires. Surgical patients reported a significant improvement in quality of life (QOLIE-10) after surgery, as was also found by Boling et al 6 The mean score at follow-up, however, still indicated an impaired quality of life. Regarding depressed mood, both groups were comparable at baseline.…”

Section: Figsupporting

confidence: 79%

“…46 In contrast, stable (although severely impaired) postoperative memory functions were reported in a noncontrolled study. 8 Finally, a predominantly favorable subjective outcome has been described by Boling et al 6 in 11 patients with bilateral TLE, 3 of whom had bilatNeuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis eral AHS. While 7 patients reported an improved quality of life, subjective memory was unchanged in 8 patients.…”

Section: ©Aans 2014mentioning

confidence: 91%

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Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Vogt¹,

Malter²,

Schoene-Bake³

et al. 2014

JNS

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Object. The purpose of this study was to retrospectively assess the objective and subjective neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis (AHS).Methods. Memory and executive functions were evaluated at baseline and at follow-up in 11 surgically treated patients and compared with 8 pharmacologically treated patients with temporal lobe epilepsy and bilateral AHS. The median follow-up duration was 16 months in the surgically treated patients and 80.5 months in the pharmacologically treated group. Subjective outcome was evaluated by questionnaires and included mood, quality of life, subjective memory, and activities of daily living.Results. At the follow-up assessment, 82% of the surgically treated patients as opposed to 0% of the nonsurgery patients were seizure free. In the surgical group, nonverbal memory performance did not change significantly in any patient after surgery, but there was a floor effect in 55% of the surgical patients. Regarding verbal memory, 9% of the surgical patients improved while 73% declined, despite severe impairments already evident at baseline. In the nonsurgery control group, 13% of the patients declined in nonverbal memory (floor effect in 63%) and 25% declined in verbal memory (floor effect in 25%) at follow-up. None of the controls improved at follow-up. Executive functions remained unchanged on an impaired level in both groups. At follow-up, the patient groups did not differ significantly with respect to mood, quality of life, subjective memory, or activities of daily living. However, in most aspects, surgically treated patients reported a slightly better subjective outcome than pharmacologically treated patients and a significantly improved quality of life.Conclusions. These results suggest that beyond benefits concerning seizure control, surgically treated patients with bilateral AHS, despite already poor baseline performance, are still at risk for severe postoperative decline in memory. In the light of predominantly minor benefits on a subjective level, the findings put the overall outcome of epilepsy surgery in bilateral AHS patients into perspective. (http://thejns.org/doi/abs/10.3171/2014.7.JNS132037) key WordS • neuropsychological outcome • temporal lobe epilepsy surgery • memory • bilateral Ammon's horn sclerosis Abbreviations used in this paper: AHS = Ammon's horn sclerosis; BDI = Beck Depression Inventory; QOLIE = Quality of Life in Epilepsy Inventory; RCI = reliable change index; TLE = temporal lobe epilepsy; VLMT = Verbaler Lern-und Merkfähigkeitstest.

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Section: Figsupporting

confidence: 79%

Section: ©Aans 2014mentioning

confidence: 91%

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Vogt¹,

Malter²,

Schoene-Bake³

et al. 2014

JNS

View full text Add to dashboard Cite

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“…HFO-generating regions identified SOZ with greater specificity and accuracy compared with that of the spike-generating regions [9,27]. Furthermore, some studies indicated that removal of the HFO-generating region predicted better surgical outcome [10][11][12][13]. These studies suggested that HFOs appeared to be reliable biomarkers of SOZ.…”

Section: Identification Of Sozmentioning

confidence: 88%

“…Reports over the last decade on human epileptic brain with intracranial recording have suggested that HFOs are linked to epileptogenic zones [6,7,9,10]. Studies the removal of HFO-generating areas rather than spike-generating areas [10][11][12][13]. Furthermore, the use of HFOs as biomarkers of epileptogenicity in resective procedures improves seizure outcome and represents a novel approach for the treatment of epilepsy.…”

Section: Introductionmentioning

confidence: 98%

Using ictal high-frequency oscillations (80–500Hz) to localize seizure onset zones in childhood absence epilepsy: A MEG study

Miao

Xiang

Tang

et al. 2014

Neuroscience Letters

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“…Bitemporal epilepsy has been defined by depth electrodes, as clear clinical and scalp EEG differences that could noninvasively distinguish bitemporal epilepsy from unilateral temporal lobe epilepsy have not been established [1]. Patients with bitemporal epilepsy are generally considered to be poorer surgery candidates than patients with unilateral temporal lobe epilepsy [2][3][4][5]. Seizure semiology is an important part of the presurgical assessment of epilepsy surgery candidates.…”

Section: Introductionmentioning

confidence: 99%

Ictal and postictal semiology in patients with bilateral temporal lobe epilepsy

Řehulka

Doležalová

Janoušová

et al. 2014

Epilepsy & Behavior

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Surgical treatment of independent bitemporal lobe epilepsy defined by invasive recordings

Cited by 46 publications

References 33 publications

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Using ictal high-frequency oscillations (80–500Hz) to localize seizure onset zones in childhood absence epilepsy: A MEG study

Ictal and postictal semiology in patients with bilateral temporal lobe epilepsy

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