Surgical treatment of gastric cancer: then and now

Olesiński, Tomasz

doi:10.5603/njo.2016.0072

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…Currently, the recommended treatment for patients with a stage above T1N0 is combination therapy, including perioperative chemotherapy, with the currently preferred quadruple FLOT regimen (fluorouracil, leucovorin, oxaliplatin, and docetaxel). This increases a patient's chance of a cure by up to 70% [2][3][4]. Of fundamental importance for the development of combination therapy for gastric cancer was the study by MacDonald et al [5].…”

Section: Introductionmentioning

confidence: 99%

The influence of surgery quality on the longtime results of gastric cancer combination therapy

Pierzankowski

Dmitruk²,

Rybski³

et al. 2022

Nowotwory. Journal of Oncology

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Introduction.The aim of this study was to analyze the influence of surgical center experience on the long term survival of patients with locoregionally advanced gastric adenocarcinoma undergoing primary surgery, followed by complementary chemoradiotherapy according to MacDonald regimen. Material and methods. 154 patients treated surgically, including 75 (48.7%) at the Maria Sklodowska-Curie National Research Institute of Oncology (NIO-PIB) in Warsaw, and 79 (51.3%) outside this center. Both groups were retrospectively analyzed. The compared groups were statistically homogeneous. The following parameters were analyzed: age, gender, tumor differentiation, TNM VII (2010) staging, nodal index, radicality of surgical treatment, tumor type according to the Lauren classification, clinical stage, presence of prognostic factors, overall survival time. Results. Among those patients operated on at NIO-PIB, 71 (94.7%) patients underwent radical resection, 4 (5.3%) cases were microscopically non-radical resection had. There were no macroscopically non-radical resections (0%). For patients operated on outside NIO-PIB, 60 (75.9%) R0 resections, 15 (19%) R1 resections and 4 (5.1%) R2 resections were performed. The percentage of radical resections was significantly higher at NIO-PIB (p = 0.001). In 77% of patients operated on at NIO-PIB, disease progression in terms of feature could be established. This percentage for patients operated on outside the NIO-PIB was 54% and was significantly lower (p = 0.001). The probability of 5-year survival was 41.6% in total, with 45.3% for the group of patients operated on in the NIO-PIB and 38.0% for the group of patients operated on outside the NIO-PIB, respectively (p = 0.628). Conclusions. The quality of surgical treatment was significantly higher in NIO-PIB. The difference in 5-year overall survival (OS) between the compared groups is not statistically significant. Complementary treatment with chemoradiotherapy (CRT) according to MacDonald regimen reduces the shortcomings in the quality of surgical treatment in locoregionally advanced gastric adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

The influence of surgery quality on the longtime results of gastric cancer combination therapy

Pierzankowski

Dmitruk²,

Rybski³

et al. 2022

Nowotwory. Journal of Oncology

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“…В доступной мировой научной литературе не приводится убедительных данных по оценке КЖ пациентов после проксимальной резекции по поводу заболеваний кардиального отдела желудка, так как не представлены четкие критерии ее оценки в зависимости от выбранных способов и методов реконструкции ЖКТ [8, [152][153][154]. Хотя приводятся данные, что КЖ может быть улучшено при проксимальной гастрэктомии за счет «правильной» (соответствующей) реконструкции пищеварительного тракта [155], а также сохранения функции дистального отдела желудка вместе с пилорическим кольцом [5].…”

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Immediate and long-term results of proximal gastric resection depending on the methods of the digestive tract continuity restoring

Тишакова¹,

Ruchkin²,

Бондаренко³

2021

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Proximal gastric resection (PGR) is still one of the most difficult and dangerous surgical interventions, and it is the only method of curative treatment of diseases of the cardiac part of the stomach in many cases. 5 types of gastrointestinal reconstruction are mainly performed after PRG: submerged rectal esophagogastroanastomosis, antireflux interposition of the jejunal segment, interposition of the jejunal segment of the jejunal pocket, interposition of the jejunal segment as a double tract and reconstruction with the formation of a gastric tube. Modern literature includes many works devoted to the development of methods of physiological reconstruction after subtotal and total removal of the stomach; however, none of the existing methods is recognized as optimal. Among the main indicators characterizing the effectiveness of PGR are the frequency and severity of the development of a large group of functional disorders, characterized as «diseases of the operated stomach», or «post-gastro-resection disorders», which significantly worsen the quality of life (QOL) and reduce the working capacity, which causes disability of the operated patients Assessment of QoL after surgery for diseases of the cardiac stomach is a fundamentally important component of monitoring the effectiveness of treatment and, therefore, allows one to determine the indications for certain types of interventions. The available world scientific literature does not provide convincing data on the assessment of QOL in patients after proximal resection for cardiac part of the stomach diseases, since there are no clear criteria for its assessment depending on the chosen methods and methods of reconstruction of gastrointestinal tract (GIT). In this regard, there is a need for further study of proximal resection with reconstruction of the gastrointestinal tract in surgical diseases of the cardiac part of the stomach on the basis of analysis of immediate and long-term results, as well as the quality of life of patients who underwent these surgical interventions.

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Surgical treatment of gastric cancer: then and now

Cited by 2 publications

References 43 publications

The influence of surgery quality on the longtime results of gastric cancer combination therapy

The influence of surgery quality on the longtime results of gastric cancer combination therapy

Immediate and long-term results of proximal gastric resection depending on the methods of the digestive tract continuity restoring

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