Surgical treatment for late-appearing adrenal metastasis from gastric cancer: report of two cases

Kim, Dong Jin; Lee, Jun Hyun; Kim, Wook

doi:10.1186/1477-7819-12-116

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Secondly, the CD8 T cells cocultured with Ly6C + MHC II + population from WT mice expressed higher expression of exhaust markers such as PD-1 and CTLA4. Several previous reports indicate CX3CR1-positive TAMs commonly display high phagocytic but immune suppressive activities (40,48,49). In MMTV-PyMT models, monocyte derived (TAMs) present cancer cell antigens and drive exhaustion of cytotoxic T cell with induction of PD1 expression (50).…”

Section: Discussionmentioning

confidence: 99%

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Keerthi Raja,

Gupta,

Atkinson

et al. 2024

Preprint

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Tumor-associated macrophages exhibit high heterogeneity and contribute to the establishment of an immunosuppressive tumor microenvironment (TME). Although numerous studies have demonstrated that extracellular factors promote macrophage proliferation and polarization, the regulatory mechanisms governing the differentiation process to generate phenotypically, and functionally diverse macrophage subpopulations remain largely unexplored. In this study, we examined the influence of interleukin 1α (IL-1α) on the development of an immunosuppressive TME using orthotopic transplantation murine models of breast cancer. Deletion of host Il1α led to the rejection of inoculated congenic tumors. Single-cell sequencing analysis revealed that CX3CR1+ macrophage cells were the primary sources of IL-1α in the TME. The absence of IL-1α reprogrammed the monocyte-to-macrophage differentiation process within the TME, characterized by a notable decrease in the subset of CX3CR+ ductal-like macrophages and an increase in iNOS-expressing inflammatory cells. Comparative analysis of gene signatures in both human and mouse macrophage subsets suggested that IL-1α deficiency shifted the macrophage polarization from M2 to M1 phenotypes, leading to enhanced cytotoxic T lymphocyte activity in the TME. Importantly, elevated levels of IL-1α in human cancers were associated with worse prognosis following immunotherapy. These findings underscore the pivotal role of IL-1α in shaping an immune-suppressive TME through the regulation of macrophage differentiation and activity, highlighting IL-1α as a potential target for breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Keerthi Raja,

Gupta,

Atkinson

et al. 2024

Preprint

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Surgical management of oligometastatic disease in gastric cancer

Jin

Tian

2020

Clinics and Research in Hepatology and Gastroenterology

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Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review

et al. 2023

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Surgical resection is rarely employed for the treatment of metastatic gastric cancer, especially in patients with adrenal metastases, which usually indicate advanced systemic dissemination. Few published case reports have thus described the use of adrenalectomy for adrenal metastases from gastric cancer. In addition, most primary gastric malignancies are gastric adenocarcinomas, and gastric large cell neuroendocrine carcinoma (GLCNEC) is less common and has a poor prognosis. We report the case of a 71-year-old man who was diagnosed with solitary adrenal metastases 10 months after radical resection for GLCNEC and who was treated by adrenalectomy. He was followed-up for 9 months after adrenalectomy, with no further evidence of disease at his last follow-up examination. This case indicates that elective surgical resection may be feasible, even in rare cases of GLCNEC metastases to the adrenal glands, provided that the patient meets certain criteria, including solitary, metachronous tumors less than 4 cm.

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Surgical treatment for late-appearing adrenal metastasis from gastric cancer: report of two cases

Cited by 3 publications

References 16 publications

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Surgical management of oligometastatic disease in gastric cancer

Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review

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