Surgical management of oligometastatic disease in gastric cancer

Jin, Peng; Ji, Xiaoyan; Tian, Yantao

doi:10.1016/j.clinre.2020.02.003

Cited by 11 publications

(9 citation statements)

References 58 publications

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“…In the first case presented, the patient had metastatic disease on diagnosis, which was restricted to a single liver metastasis of a small diameter, in line with favorable prognosis factors described in the current literature [ 19 ]. A favorable response to neoadjuvant chemotherapy further reinforced that this case was a good candidate for resection.…”

Section: Discussionmentioning

confidence: 75%

“…Multiple definitions have been proposed for oligometastasis, all of which center around a small number of metastases that are restricted to one or two sites. While definitive proof of the validity of such a concept remains to be reached, molecular findings suggest differing tumor biologies between multiple and oligometastatic cancers [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports

Takeda

Garcia

Ueda

et al. 2020

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports

Takeda

Garcia

Ueda

et al. 2020

International Journal of Surgery Case Reports

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“…Traditionally, oligometastasis has been defined as an intermediate state between localized and widespread systemic disease with the presence of fewer than 5 metastases [ 423 ]. However, the definition is still not clear, and oligometastasis is generally defined as fewer than 3 or 5 metastatic lesions involving 1 or 2 organs [ 424 425 ].…”

Section: Treatment For Far Advanced Gastric Cancermentioning

confidence: 99%

Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach

et al. 2023

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Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology and guideline development methodology. Total of 33 key questions were updated or proposed after a collaborative review by the working group and 40 statements were developed according to the systematic review using the MEDLINE, Embase, Cochrane Library and KoreaMed database. The level of evidence and the grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. Evidence level, benefit, harm, and clinical applicability was considered as the significant factors for recommendation. The working group reviewed recommendations and discussed for consensus. In the earlier part, general consideration discusses screening, diagnosis and staging of endoscopy, pathology, radiology, and nuclear medicine. Flowchart is depicted with statements which is supported by meta-analysis and references. Since clinical trial and systematic review was not suitable for postoperative oncologic and nutritional follow-up, working group agreed to conduct a nationwide survey investigating the clinical practice of all tertiary or general hospitals in Korea. The purpose of this survey was to provide baseline information on follow up. Herein we present a multidisciplinary-evidence based gastric cancer guideline.

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“… 6 Autopsy data show that adrenal metastasis also occurs in 16% to 18% of patients with gastric cancer, with the hematologic or lymphatic pathway being the most common route; however, it is usually detected as part of multi-organ metastases, with solitary adrenal metastases being relatively uncommon. 7 This suggests that adrenal metastasis in these patients represents part of advanced systemic spread with a poor prognosis, and is thus usually not suitable for surgical treatment; surgical resection of adrenal metastases from stomach cancer is therefore uncommon. Gastric neuroendocrine carcinoma is an extremely aggressive malignancy with a substantially worse prognosis than gastric adenocarcinoma, which has already spread to lymph nodes or distant organs at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review

et al. 2023

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Surgical resection is rarely employed for the treatment of metastatic gastric cancer, especially in patients with adrenal metastases, which usually indicate advanced systemic dissemination. Few published case reports have thus described the use of adrenalectomy for adrenal metastases from gastric cancer. In addition, most primary gastric malignancies are gastric adenocarcinomas, and gastric large cell neuroendocrine carcinoma (GLCNEC) is less common and has a poor prognosis. We report the case of a 71-year-old man who was diagnosed with solitary adrenal metastases 10 months after radical resection for GLCNEC and who was treated by adrenalectomy. He was followed-up for 9 months after adrenalectomy, with no further evidence of disease at his last follow-up examination. This case indicates that elective surgical resection may be feasible, even in rare cases of GLCNEC metastases to the adrenal glands, provided that the patient meets certain criteria, including solitary, metachronous tumors less than 4 cm.

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Surgical management of oligometastatic disease in gastric cancer

Cited by 11 publications

References 58 publications

Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports

Primary tumor resection of metastatic gastric cancer in a multimodal era: Two case reports

Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach

Solitary metachronous adrenal metastasis after radical resection of gastric large cell neuroendocrine carcinoma: a case report and literature review

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