Surgical treatment and prognosis in patients with high-grade soft tissue malignant fibrous histiocytoma of the extremities

Kontogeorgakos, Vasileios; Eward, William C.; Brigman, Brian E.

doi:10.1007/s00402-012-1510-y

Cited by 22 publications

(18 citation statements)

References 31 publications

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“…[12] Postoperative radiation therapy has been recommended for patients with marginal surgical margins in postoperative histological evaluation. [13,15,16] In our series, radiotherapy was administered to three patients with marginal surgical margins. Reports of the outcome of the patients who received loco-regional treatment as surgery alone and/or radiation therapy were disappointing, and adjuvant chemotherapy was introduced with encouraging results.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of long bones: long-term follow-up

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et al. 2016

Eklem Hastalik Cerrahisi

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ÖZAmaç: Bu çalışmada malign fibröz histiyositoma tanılı hastalar değerlendirildi ve sağkalım süresi ile ilişkili muhtemel prognostik faktörler araştırıldı. Hastalar ve yöntemler: Mayıs 1994 -Eylül 2013 tarihleri arasında yapılan çalışmaya malign fibröz histiyositoma tanılı 14 hasta (12 erkek, 2 kadın; ortanca 48 yıl; dağılım 17-64 yıl) dahil edildi. Hastaların demografik özellikleri, patolojinin yeri, histolojik bulgular, cerrahi sınırlar ve tedavi yöntemleri değerlendirildi ve bu parametrelerin sağkalım üzerindeki etkileri araştırıldı.Bulgular: En sık tutulan kemik femur idi, bunu tibia ve humerus izledi. Hastaların takip süresi ortanca 129 ay idi. On üç hastada ekstremite koruyucu cerrahi ve bir hastada amputasyon uygulandı. Üç hastada cerrahi sınırlar marjinal idi ve hastalığın lokal kontrolü için ameliyat sonrası radyoterapi uygulandı. Bu hastalarda hiç lokal nüks olmasa da iki hastada uzak metastaz gelişti, bu da cerrahi sınırın sağkalım üzerinde etkili önemli bir faktör olduğunu ortaya çıkardı. Beş yıllık sağkalım oranı geniş cerrahi sınırları olan hastalarda %81.9, marjinal sınırları olan hastalarda %33.3 idi. Sonuç: Geniş sınırlarla cerrahi eksizyon ve adjuvan kemoterapi yeterli hastalık kontrolü ve daha uzun sağkalım sağladı. Sağkalım süresi ile istatistiksel olarak anlamlı şekilde ilişkili tek prognostik faktör cerrahi sınırlar idi. Damar ve sinir yapılarıyla yakın ilişki nedeniyle cerrahi sırasında yeterli geniş cerrahi sınır elde edilememe şüphesi olduğunda, neoadjuvan kemoterapi kullanılabilir.

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Section: Discussionmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of long bones: long-term follow-up

Özkurt

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et al. 2016

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“…Although great advances have been achieved in the treatment, oncological outcome in spinal sarcomas is worse than that of soft tissue sarcomas in extremities20,33,40). In extremity sarcomas, many reports on survival and recurrence are available2,31,36,37). Vasileios et al37) reported that 5-year survival rate of MFH patients was 66% and the recurrence and the metastasis rates were 31%.…”

Section: Discussionmentioning

confidence: 99%

“…In extremity sarcomas, many reports on survival and recurrence are available2,31,36,37). Vasileios et al37) reported that 5-year survival rate of MFH patients was 66% and the recurrence and the metastasis rates were 31%. Tural et al36) reported that the recurrence rate was 23% and 5-year survival rate was 72% through retrospective study of adult Ewing sarcoma patients.…”

Section: Discussionmentioning

confidence: 99%

“…For this reason the establishment of a bone tumor registry provides a valuable source of information and facilitates reasonable treatment of these tumors16,28). It was known that primary sarcomas of the spine had low survival and high recurrence rate compared to sarcoma occurring in extremity2,8,22,24,31,37,41). The radical or wide excision is required in sarcoma treatment, but it is difficult to perform the radical excision due to the risk of neural or vascular injuries7,19).…”

Section: Introductionmentioning

confidence: 99%

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Survival and Recurrence Rate after Treatment for Primary Spinal Sarcomas

Cho

Chang

2013

J Korean Neurosurg Soc

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ObjectiveWe have limited understanding on the presentation and survival of primary spinal sarcomas. The survival, recurrence rate, and related prognostic factors were investigated after treatment for primary sarcomas of the spine.MethodsRetrospective analysis of medical records and radiological data was done for 29 patients in whom treatment was performed due to primary sarcoma of the spine from 2000 to 2010. As for treatment method, non-radical operation, radiation therapy, and chemotherapy were simultaneously or sequentially combined. Overall survival (OS), progression free survival (PFS), ambulatory function, and pain status were analyzed. In addition, factors affecting survival and recurrence were analyzed : age (≤42 or ≥43), gender, tumor histologic type, lesion location (mobile spine or rigid spine), weakness at diagnosis, pain at diagnosis, ambulation at diagnosis, initial treatment, radiation therapy, kind of irradiation, surgery, chemotherapy and distant metastasis.ResultsMedian OS was 60 months, the recurrence rate was 79.3% and median PFS was 26 months. Patients with distant metastasis showed significantly shorter survival than those without metastasis. No factors were found to be significant relating to recurrence. Prognostic factor associated with walking ability was the presence of weakness at diagnosis.ConclusionPrimary spinal sarcomas are difficult to cure and show high recurrence rate. However, the development of new treatment methods is improving survival.

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“…30 Nevertheless, the Association of Directors of Anatomical and Surgical Pathology recommends that any margin macroscopically more than 5 cm is believed to be clear. 31,32 In our patients, the lesion was removed as widely or radically as possible.…”

Section: Discussionmentioning

confidence: 99%