Surgical specimen can be replaced by core samples in assessment of ER, PR and HER-2 for invasive breast cancer

Sutela, Anna; Vanninen, Ritva; Sudah, Mazen; Berg, M.; Kiviniemi, Vesa; Rummukainen, Jaana; Kataja, Vesa; Kärjä, Vesa

doi:10.1080/02841860701441822

Cited by 43 publications

(40 citation statements)

References 22 publications

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“…Sutela et al (8) reported higher concordance in PR results than ER between CNBS and SS in their 41 cases (83% for ER and 88% for PR) while discordance was mostly detected as positive HR in CNB with negativity in SS. The discordance of PR results in CNBS compared with SS was attributed to scarcity of biopsy numbers in CNB in the work of Tamaki et al (9) (overall concordance rate of 92.9% for ER and 89.3% for PR in 353 cases) who showed a high agreement in PR of the two specimens when more than 3 cores were taken.…”

Section: Discussionmentioning

confidence: 92%

Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

Omranipour¹,

Alipour²,

Hadji³

et al. 2013

Iran Red Crescent Med J

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BackgroundDiagnosis of breast cancer is completed through core needle biopsy (CNB) of the tumors but there is controversy on the accuracy of hormone receptor results on CNB specimens.ObjectivesWe undertook this study to compare the results of hormone receptor assessment in CNB and surgical samples on our patients.Patients and MethodsHormone receptor status was determined in CNB and surgical samples in breast cancer patients whose CNB and operation had been performed in this institute from 2009 to 2011 and had not undergone neoadjuvant chemotherapy.ResultsAbout 350 patients, 60 cases met all the criteria for entering the study. The mean age was 49.8 years. Considering a confidence interval (CI) of 95%, the sensitivity of ER and PR assessment in CNB was 92.9% and 81%, respectively and the specificity of both was 100%. The Accuracy of CNB was 98% for ER and 93% for PR.ConclusionsOur results confirm the acceptable accuracy of ER assessment on CNB. The subject needs further investigation in developing countries where omission of the test in surgical samples can be cost and time-saving.

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Section: Discussionmentioning

confidence: 92%

Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

Omranipour¹,

Alipour²,

Hadji³

et al. 2013

Iran Red Crescent Med J

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“…This may be due to better fixation of core biopsy material compared to surgical excision specimen. There are also high concordance rates between core biopsies taken from different parts of the same tumour (ER 100%, PR 85%), 11 as well as between core biopsies taken from the different foci of a multifocal disease. 12 Situations where repeated ER/PR testing should be conducted on subsequent excision are listed in Table 1.…”

Section: Receptor Status Changementioning

confidence: 91%

ER, PR and HER2 testing in breast cancer

Han

2014

Diagnostic Histopathology

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“…The incidence of breast cancer has increased worldwide, which is partly considered to be due to mass screening programs resulting in the discovery of clinically occult or early breast lesions (1). Early clinical detection of breast cancer through screening has therefore led to the detection of the tumor at a relatively earlier clinical stage.…”

Section: Introductionmentioning

confidence: 99%

Breast Ultrasonographic and Histopathological Characteristics Without Any Mammographic Abnormalities

Tamaki

Ishida

Miyashita

et al. 2012

Japanese Journal of Clinical Oncology

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Objective: We evaluated ultrasonographic findings and the corresponding histopathological characteristics of breast cancer patients with Breast Imaging Reporting and Data System (BI-RADS) category 1 mammogram. Methods: We retrospectively reviewed the ultrasonographic findings and the corresponding histopathological features of 45 breast cancer patients with BI-RADS category 1 mammogram and 537 controls with mammographic abnormalities. We evaluated the ultrasonographic findings including mass shape, periphery, internal and posterior echo pattern, interruption of mammary borders and the distribution of low-echoic lesions, and the corresponding histopathological characteristics including histological classification, hormone receptor and human epidermal growth factor receptor 2 status of invasive ductal carcinoma and ductal carcinoma in situ, histological grade, mitotic counts and lymphovascular invasion in individual cases of BI-RADS category 1 mammograms and compared with those of the control group. Results: The ultrasonographic characteristics of the BI-RADS category 1 group were characterized by a higher ratio of round shape (P , 0.001), non-spiculated periphery (P ¼ 0.021), non-interruption of mammary borders (P , 0.001) and non-attenuation (P ¼ 0.011) compared with the control group. A total of 52.6% of low-echoic lesions were associated with spotted distribution in the BI-RADS 1 group, whereas 25.8% of low-echoic lesions were associated with spotted distribution in the control group (P ¼ 0.012). As for histopathological characteristics, there was a statistically higher ratio of triple-negative subtype (P ¼ 0.021), and this particular tendency was detected in histological grade 3 in the BI-RADS category 1 group (P ¼ 0.094). Conclusion: We evaluated ultrasonographic findings and the corresponding histopathological characteristics for BI-RADS category 1 mammograms and noted significant differences among these findings in this study. Evaluation of these ultrasonographic and histopathological characteristics may provide a more accurate ultrasonographic screening system for breast cancer in Japanese women.

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Surgical specimen can be replaced by core samples in assessment of ER, PR and HER-2 for invasive breast cancer

Cited by 43 publications

References 22 publications

Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

ER, PR and HER2 testing in breast cancer

Breast Ultrasonographic and Histopathological Characteristics Without Any Mammographic Abnormalities

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