Accuracy of Estrogen and Progesterone Receptor Assessment in Core Needle Biopsy Specimens of Breast Cancer

Abstract

BackgroundDiagnosis of breast cancer is completed through core needle biopsy (CNB) of the tumors but there is controversy on the accuracy of hormone receptor results on CNB specimens.ObjectivesWe undertook this study to compare the results of hormone receptor assessment in CNB and surgical samples on our patients.Patients and MethodsHormone receptor status was determined in CNB and surgical samples in breast cancer patients whose CNB and operation had been performed in this institute from 2009 to 2011 and had not undergone neoadjuvant chemotherapy.ResultsAbout 350 patients, 60 cases met all the criteria for entering the study. The mean age was 49.8 years. Considering a confidence interval (CI) of 95%, the sensitivity of ER and PR assessment in CNB was 92.9% and 81%, respectively and the specificity of both was 100%. The Accuracy of CNB was 98% for ER and 93% for PR.ConclusionsOur results confirm the acceptable accuracy of ER assessment on CNB. The subject needs further investigation in developing countries where omission of the test in surgical samples can be cost and time-saving.

Correlation of morphological profile and receptor status in breast carcinoma: An institutional study in tertiary care hospital

“…It is well known that breast cancer prognosis depends on various clinicopathological factors including tumor size, tumor grade, hormone receptor status, HER-2 status and metastatic status of lymph nodes [6,8] . Age range among Indian breast cancer patients is found to be lower when compared to the Western countries with an average difference of one decade.…”

“…There has been realization that the presence of ER/PR receptor in tumor tissue has a strong correlation with response to hormonal therapy [5] . In recent times, hormonal status determination on biopsy specimen has been advocated as a standard practice [6] . The hormone receptors play an essential role in the development, therapeutic and progression of the disease along with identification of patients with lower risk of relapse [7] .…”

The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study

“…CNB has an undeniable role to diagnose both palpable and impalpable lesions ( 1 , 2 , 6 ), and provides substantial information to determine the subsequent therapeutic strategies due to the immunohistochemical evaluations of CNB, particularly in the setting of neo adjuvant therapy ( 6 , 7 ). It is an inevitable practical benefit to avoid further unnecessary surgical biopsies ( 8 ).…”

Changes of T2 Relaxation Time From Neoadjuvant Chemotherapy in Breast Cancer Lesions

“…Clinical palpation, mammography and ultrasound examination could not reliably monitor the response to NAC. For the diagnosis of breast cancer, biopsy has obvious advantages than magnetic resonance imaging (MRI), but it is an invasive examination (2). MRI has a higher sensitivity (88.1%) than mammography and ultrasound (3-6).…”