Surgical Risk Prediction for Nasolacrimal Duct Obstruction in Radioactive Iodine-Treated Thyroid Cancer: A Nationwide Cohort Study

Lee, Ju‐Yeun; Woo, Kyung In

doi:10.1089/thy.2021.0418

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Lee et al evaluated the risk of surgical intervention to treat nasolacrimal duct obstruction for patients who were treated with I-131 and determined the high-risk groups. 14 They reported a 0.93% surgical risk in the I-131 group versus a 0.13% in the group that did not receive I-131 14 and concluded that there was a significantly higher risk of needing surgical intervention in the I-131 group. Additionally, they observed that higher-risk groups included those who received higher dosage of I-131 and patients younger than 50 years old.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, they observed that higher-risk groups included those who received higher dosage of I-131 and patients younger than 50 years old. 14 Previously used for treatment of hyperthyroidism, 15 perchlorate is a potent oxidizing anion and inhibitor of iodine uptake in the thyroid gland. 16 Sodium-iodide transporter has a higher affinity to perchlorate than iodine, and this results in a competitive inhibition of iodine absorption in the thyrocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, they observed that higher-risk groups included those who received higher dosage of I-131 and patients younger than 50 years old. 14…”

Section: Discussionmentioning

confidence: 99%

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Topical Application of Perchlorate: A Toxicity Study in Rats

Ulloa-Padilla,

Burkat,

Morgenstern

2024

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To investigate the ocular safety profile of topical perchlorate as a potential preventive treatment for nasolacrimal obstruction associated with excessive use of radioactive iodine therapy. Methods: Nine Wistar male rats (18 eyes) were randomly assigned to receive an ocular application (topical eye drop on the OD, 3 times a day for 5 days) consisting of either: 1) sterile saline solution, 2) 30 mg/ml NaClO4 or 3) 30 mg/ml KClO4. The rat eyes were examined daily for corneal cloudiness/clarity, discharge, mucous secretions, conjunctival injection, eyelid erythema, and/or changes in behavior. Seven days after the first dose, the rats were euthanized and OU were harvested, fixed, embedded in paraffin, and stained with H&E and Masson’s trichrome using standard techniques. Results: The data collected over the 7 days revealed no behavior changes or ocular complications in any of the 3 study groups. Pathologic analysis of the corneas revealed normal findings on all groups without signs of inflammation, fibrosis, or any other abnormality, and no difference between the treated and control eyes. Conclusions: The findings of this study suggest that the use of topical perchlorate is safe to use on eyes in high concentrations. The efficacy of this compound in minimizing fibrosis of the nasolacrimal sac and duct warrants further study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%