Topical Application of Perchlorate: A Toxicity Study in Rats
Jan P. Ulloa-Padilla,
Cat N. Burkat,
Kenneth E. Morgenstern
Abstract:Purpose:
To investigate the ocular safety profile of topical perchlorate as a potential preventive treatment for nasolacrimal obstruction associated with excessive use of radioactive iodine therapy.
Methods:
Nine Wistar male rats (18 eyes) were randomly assigned to receive an ocular application (topical eye drop on the OD, 3 times a day for 5 days) consisting of either: 1) sterile saline solution, 2) 30 mg/ml NaClO4 or 3) 30 mg/ml KClO4. The rat eyes we… Show more
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