Surgical resection of recurrent bilateral mediastinal liposarcoma through the clamshell approach

Ohta, Yasuhiko; Murata, Tomomi; Tamura, Masaya; Sato, Hideo; Kuroda, Hiroshi; Kawakami, Kazuyoshi

doi:10.1016/s0003-4975(03)01242-6

Cited by 23 publications

(21 citation statements)

References 9 publications

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“…Klimstra et al [1] reported 7 of 23 patients with incomplete resection who succumbed to tumor recurrence within 2.6 years after surgery, whereas 11 of the patients were free of disease after 1.6 years. The 5-year survival rate was 34.9% for the well-differentiated subtype and 21.0% for the pleomorphic subtype, despite the attempted resection of recurrent liposarcomas in several cases [8][9][10].…”

Section: Discussionmentioning

confidence: 96%

Successful resection of a massive mediastinal liposarcoma that rapidly extended into the entire left thoracic cavity: report of a case

et al. 2011

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Primary mediastinal liposarcomas are rare malignancies, comprising fewer than 1% of all mediastinal tumors. We herein report a radical resection of a massive liposarcoma arising from the anterior mediastinum. A 63-year-old male patient presented with a 4-week history of dyspnea that had worsened over the previous several days. The patient had also experienced hoarseness for 2 weeks. Chest X-ray and computed tomography revealed a huge tumor occupying the entire left thoracic cavity. Anesthesia was induced when the patient was in the left semilateral position. The patient was moved into the right lateral position after initially stabilizing anesthesia with separate lung ventilation. The fourth rib was initially resected for thoracotomy, but there was no clearance between the tumor and the adjacent mediastinal structures, and two more ribs were therefore removed. The tumor had not invaded the other structures such as the chest wall, lung, or mediastinum. To reduce the tumor blood flow, the left internal mammary artery was ligated before the tumor was resected en bloc. The tumor was diagnosed as a liposarcoma arising from the thymus. The patient remains alive with no evidence of disease recurrence at 22 months after the operation.

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Section: Discussionmentioning

confidence: 96%

Successful resection of a massive mediastinal liposarcoma that rapidly extended into the entire left thoracic cavity: report of a case

et al. 2011

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“…Liposarcoma arises from primitive mesenchymal cells and commonly occurs in the lower extremities (75% of cases), with a less frequent rate of occurrence in the retroperitoneum (20% of cases) (8)(9)(10). Alternative sites of liposarcoma, such as the abdomen, vulva and buttocks, have also been reported (11); however, primary liposarcoma of the mediastinum is rare, comprising <1% of all mediastinal tumor cases (only 130 cases have been described in the Western literature thus far) (3).…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis is dependent on the histological subtype and the completion of surgical resection, with myxoid or pleomorphic subtype patients exhibiting a poorer prognosis compared with well-differentiated tumors (12). Furthermore, a number of previous studies have reported a five-year survival rate of 34.9% for the well-differentiated subtype and 21.0% for the pleomorphic subtype (8,10,19).…”

Section: F Ementioning

confidence: 99%

Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Zhang

et al. 2015

Oncology Letters

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Abstract. Liposarcoma has previously been described in Western studies, however, such cases are rarely reported in the mediastinum. In addition, the presence of a liposarcoma with smooth muscle and neural differentiation has not been previously reported. Thus, the present study describes the rare case of a 28-year-old Chinese male admitted to our hospital with the symptoms of chest tightness and shortness of breath due to a recurrent fibrolipoma in the mediastinum. The resected tumor measured 23 cm at its largest diameter, with histopathological and immunohistochemical features indicating a well-differentiated liposarcoma accompanied by smooth muscle and neural differentiation. Following the resection, the patient underwent radiation treatment and remains alive with no evidence of disease recurrence at two months post-surgery. To the best of our knowledge, the present study is the first to report a case of liposarcoma with smooth muscle and neural differentiation, which indicates that liposarcomas could potentially originate from stem cells. The present study highlights the fact that pathologists must carefully investigate the histopathological characteristics of liposarcomas in order to obtain an accurate diagnosis.

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“…This fact is consistent with the previous reports that liposarcomas tend to result in a local recur rence even if they were welldifferentiated tumors. 4,6,7) Brenner and colleagues reported the relationship between the histological subtypes of liposarcoma and the SUV max on PETCT scan. Significant differences were found for SUV max among tumor subtypes, and welldifferentiated liposarcoma showed a significantly lower SUV max (2.3 ± 1.7) than myxoid/round cell and pleomorphic subtypes.…”

Section: Discussionmentioning

confidence: 99%

Surgical Resection of a Massive Primary Mediastinal Liposarcoma Using Clamshell Incision Combined with Lower Median Sternotomy: Report of a Case

Hirano

Yamamoto

Ichimura

et al. 2014

ATCS

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We experienced a case of massive mediastinal liposarcoma expanding to the bilateral pleural cavities. Preoperative positron emission tomography-computed tomography scan showed that the uptake of 18 F-fluorodeoxyglucose (FDG) into the tumor was slight for its size. Clamshell incision together with lower median sternotomy provided the excellent visualization and the complete resection of the tumor. The surgical resection should be performed even for a massive liposarcoma, especially if the uptake of F-FDG into the tumor is low, as complete surgical resection is the only definitive treatment for liposarcoma.

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Surgical resection of recurrent bilateral mediastinal liposarcoma through the clamshell approach

Cited by 23 publications

References 9 publications

Successful resection of a massive mediastinal liposarcoma that rapidly extended into the entire left thoracic cavity: report of a case

Successful resection of a massive mediastinal liposarcoma that rapidly extended into the entire left thoracic cavity: report of a case

Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Surgical Resection of a Massive Primary Mediastinal Liposarcoma Using Clamshell Incision Combined with Lower Median Sternotomy: Report of a Case

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