Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Ma, Jun; Zhang, Hongmei; Zhang, Li‐Wang; Zheng, Minwen; Yu, Min

doi:10.3892/ol.2015.3103

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…In the literature, most studies of GMTs are published as case reports. [ 11 - 15 ] Our study is, therefore, valuable as it analyzed a series of clinical cases for guiding the treatment of GMTs. Our study results showed a good prognosis in both our cohort and the cases retrieved from the NCBI database using RS.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of giant mediastinal tumors

Qin

2021

Turk Gogus Kalp Dama

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Background This study aims to evaluate the surgical treatment outcomes of giant mediastinal tumors. Methods Between July 2013 and July 2018, medical data of a total of 31 patients (26 males, 5 females; mean age 27.7±8.2 years; range, 18 to 56 years) who underwent radical surgery for a giant mediastinal tumor in our center and 47 cases (26 males, 21 females; mean age 45.4±16.7 years; range, 19 to 62 years) of giant mediastinal tumors retrieved from the National Center for Biotechnology Information database were retrospectively reviewed. Two-year overall survival and disease-free survival rates of the patients were evaluated. Results All patients underwent radical surgery (R0 resection). Symptoms caused by giant mediastinal tumors were relieved after radical surgery during follow-up. The two-year overall survival and disease-free survival rates were 100% and 86.7%, respectively, indicating a good prognosis. The surgical procedures for malignancies were more difficult than those for benign pathologies. Conclusion Radical surgery is the mainstay for treatment of giant mediastinal tumors to relieve symptoms in a short period of time and to achieve a good prognosis for up to two years, regardless of adjuvant therapy. The surgical route should be cautiously planned before radical surgery to reduce complications.

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Section: Discussionmentioning

confidence: 99%

Surgical treatment of giant mediastinal tumors

Qin

2021

Turk Gogus Kalp Dama

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“…[ 7 – 9 ] These tumors are characterized by amplification of MDM2 and CDK4 genes on chromosome 12. [ 10 ] Most of these mass are identified incidentally or worked up secondary to complications by compression or irritation of adjacent structures. The possible symptoms of mediastinal liposarcoma are dyspnea, wheezing, chest pain, cough, SVC (superior vena cava) compression and voice hoarseness.…”

Section: Discussionmentioning

confidence: 99%

Giant primary liposarcoma of the anterior mediastinum

Yang

Bai

et al. 2018

Medicine

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Rationale:Liposarcoma is a cancerous mesenchymal tumor and the most common soft-tissue sarcoma that starts in the adipose tissue. Liposarcoma is commonly found in lower extremities and retroperitoneum, but rarely occurs in the mediastinum.Patient concerns:A 63-year-old male was referred to our clinic with a 6-month history of chronic cough and dyspnea.Diagnose:Chest x-rays demonstrated a large mass occupying the left hemithorax. Contrast-enhanced computed tomography (CT) revealed a large mass in the anterior mediastinum, which caused the extrinsic compression of the main and left pulmonary artery and the right shift of mediastinum. Diagnosis of liposarcoma was confirmed by microscopic examination and immunohistochemistry analysis.Interventions:The patient underwent a thoracotomy for resection of the mediastinal lesion via left thoracic approach.Outcomes:The patient discharged without any complications and has been continuing to follow up in clinic without any complaints.Lessons:The primary mediastinal liposarcoma is rare, and we recommend that the liposarcoma should be considered in the differential diagnosis of a patient presenting with a mediastinal mass.

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“…An increase in the MDM2 and CDK2 genes that are located on chromosome 12 is a distinguishing feature of the tumour [ 4 ]. In addition to advanced age, contact with radiation and toxic substances is also considered to be a major risk factor for the condition [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Myxomatous Liposarcoma of the Mediastinum: A Review of the Literature

Bokhari¹,

Haseeb²,

Baig³

et al. 2022

Cureus

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Myxomatous liposarcoma is an extremely rare type of mediastinal tumour that manifests in a manner comparable to other lung pathologies. Chest pain, shortness of breath, and dysphagia are the common presenting complaints. Radiological examinations or postoperative histological examinations provide the majority of the diagnostic evidence. The cornerstone of therapy consists of surgery and sometimes chemotherapy. Those who are afflicted have a better chance of experiencing favourable outcomes if they receive a diagnosis and treatment quickly.

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Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Cited by 8 publications

References 13 publications

Surgical treatment of giant mediastinal tumors

Surgical treatment of giant mediastinal tumors

Giant primary liposarcoma of the anterior mediastinum

Myxomatous Liposarcoma of the Mediastinum: A Review of the Literature

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