Giant primary liposarcoma of the anterior mediastinum

Abstract

Rationale:Liposarcoma is a cancerous mesenchymal tumor and the most common soft-tissue sarcoma that starts in the adipose tissue. Liposarcoma is commonly found in lower extremities and retroperitoneum, but rarely occurs in the mediastinum.Patient concerns:A 63-year-old male was referred to our clinic with a 6-month history of chronic cough and dyspnea.Diagnose:Chest x-rays demonstrated a large mass occupying the left hemithorax. Contrast-enhanced computed tomography (CT) revealed a large mass in the anterior mediastinum, which caused the extrinsic compression of the main and left pulmonary artery and the right shift of mediastinum. Diagnosis of liposarcoma was confirmed by microscopic examination and immunohistochemistry analysis.Interventions:The patient underwent a thoracotomy for resection of the mediastinal lesion via left thoracic approach.Outcomes:The patient discharged without any complications and has been continuing to follow up in clinic without any complaints.Lessons:The primary mediastinal liposarcoma is rare, and we recommend that the liposarcoma should be considered in the differential diagnosis of a patient presenting with a mediastinal mass.

Diagnosis and Prognosis of Retroperitoneal Liposarcoma: A Single Asian Center Cohort of 57 Cases

“…LPS mostly occurs in the extremities, followed by the retroperitoneum. There have also been reports of LPS in rare locations, such as the mediastinum, larynx, or para-testicular tissue [ 20 – 22 ]. The high occurrence in the retroperitoneum may be attributed to metastasis of LPS from other parts of the body, especially those where fat is abundant [ 1 , 2 , 23 ].…”

Incidental dedifferentiated mediastinal liposarcoma on F-18-fluciclovine PET/CT

“…Liposarcomas arising from the mediastinum account for < 1% of all liposarcomas [4]. They most commonly occur in patients over the age of 40 with a mean age of 43-56 years old [5][6][7].…”

Diagnosis and Prognosis of Retroperitoneum Liposarcoma: a single Asian center cohort of 57 cases

“…[5] LPS mostly occurs in extremities, followed by retroperitoneum, and there are also literatures reporting LPS founded in rare locations, such as mediastinum, larynx or paratesticular. [20][21][22] High occurrence of retroperitoneum may be attributed to metastasis of LPS from other parts of body, especially where fat is abundant. [1,2,23] Primary retroperitoneal LPS usually originates in the perirenal fat, and there were 19 (33%) perirenal LPS or LPS directly invading kidney in our cohort.…”