Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging

Yang, Rui‐Qin; Lou, Kangliang; Wang, Peiyuan; Gao, Yiyang; Zhang, Yong‐Qu; Chen, Min; Huang, Wen‐He; Zhang, Guojun

doi:10.1002/smtd.202001066

Cited by 86 publications

(59 citation statements)

References 148 publications

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“…Very recently, near-infrared zone II (1000-1700nm, NIR Ⅱ) probes and multiphoton probes with deeper penetrating ability have also been developed for RONS imaging of AKI sites. Fluorescent probes in the near-infrared zone II (1000-1700nm, NIR Ⅱ) have lower background interference than the probes in the near-infrared zone I (750-900 nm, NIR I) ( Figure 7 F ) 96 - 98 . Chen et al developed a kidney targeting peptide coupled NIR Ⅱ probe (KTP5-ICG-GNP) to diagnose AKI early with low spontaneous fluorescence background 99 .…”

Section: Rons Imaging Probesmentioning

confidence: 99%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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Many factors such as trauma and COVID-19 cause acute kidney injury (AKI). Late AKI have a very high incidence and mortality rate. Early diagnosis of AKI provides a critical therapeutic time window for AKI treatment to prevent progression to chronic renal failure. However, the current clinical detection based on creatinine and urine output isn't effective in diagnosing early AKI. In recent years, the early diagnosis of AKI has made great progress with the advancement of information technology, nanotechnology, and biomedicine. These emerging methods are mainly divided into two aspects: First, predicting AKI through models construct by machine learning; Second, early diagnosis of AKI through detection of newly-discovered early biomarkers. Currently, these methods have shown great potential and become an attractive tool for the early diagnosis of AKI. Therefore, it is very important to discuss and summarize these methods for the early diagnosis of AKI. In this review, we first systematically summarize the application of machine learning in AKI prediction algorithms and specific scenarios. In addition, we introduce the key role of early biomarkers in the progress of AKI, and then comprehensively summarize the application of emerging detection technologies for early AKI. Finally, we discuss current challenges and prospects of machine learning and biomarker detection. The review is expected to provide new insights for early diagnosis of AKI, and provided important inspiration for the design of early diagnosis of other major diseases.

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Section: Rons Imaging Probesmentioning

confidence: 99%

Emerging early diagnostic methods for acute kidney injury

Xiao¹,

Huang²,

Yang³

et al. 2022

Theranostics

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“…Compared with organic NIR-II fluorescent probes, inorganic NIR-II fluorescent probes, including QDs, SWCNTs, and rare-earth-doped nanoparticles (RENPs) have excellent quantum yield and high stability [ 40 , 41 ]. Among the multiple NIR-II fluorescent probes reported thus far, QDs have attracted much attention due to their excellent fluorescence quantum yield [ 42 ].…”

Section: Nir-ii Fluorescent Probesmentioning

confidence: 99%

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Pan

et al. 2021

Biosensors

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Recently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific targeting to biological tissues, showing a higher imaging signal-to-background ratio and a lower detection limit. Therefore, it is of great significance to utilize disease-associated endogenous stimuli (such as pH values, enzyme existence, hypoxia condition and so on) to activate the NIR-II probes and achieve switchable fluorescent signals for specific deep bioimaging. This review introduces recent strategies and mechanisms for activatable NIR-II fluorescent probes and their applications in biosensing and bioimaging. Moreover, the potential challenges and perspectives of activatable NIR-II fluorescent probes are also discussed.

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“…Practically, some NIR fluorescent dyes, such as indocyanine green (ICG) and methylene blue, have been approved by Food and Drug Administration for clinic use, indicating great clinical value of NIR fluorescence imaging. 17 , 18 In some of the latest studies, a variety of NIR dyes after specific modifications could bring signals to specific lesion areas such as various tumours from different origins, 19 , 20 and specific tissues, 16 to guide the operators for further medical actions. Therefore, by combining these two imaging techniques, MRI and optical imaging, we can obtain both accurate preoperative diagnostic information and intraoperative pathological information to provide guidance for a more precise surgical resection of tumours.…”

Section: Introductionmentioning

confidence: 99%

Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

Xie

Zeng

et al. 2021

Sig Transduct Target Ther

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Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles (SPIONs) modified with indocyanine (Cy7) molecules and peptides (ANG or DANG) to locate malignant gliomas and guide accurate excision. Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro, and both could mediate precise aggregation of the nanoprobes at gliomas sites in in vivo magnetic resonance imaging (MRI) and ex vivo near-infrared (NIR) fluorescence imaging. However, compared with ANG/Cy7-SPIONs probes, DANG/Cy7-SPIONs probes exhibited better enhanced MR imaging effects. Combining all these features together, this MRI/NIR fluorescence imaging dual-modal nanoprobes modified with retro-enantio isomers of the peptide have the potential to accurately display GBMs preoperatively for precise imaging and intraoperatively for real-time imaging.

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Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging

Cited by 86 publications

References 148 publications

Emerging early diagnostic methods for acute kidney injury

Emerging early diagnostic methods for acute kidney injury

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

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