Surgical Margins Influencing Oncological Results in Osteosarcoma

Intraosseous temperature during autoclaving

“…The safe resection of bone tumours has been the subject of numerous investigations (Enneking, Spanier and Good man 1980;Campanacci and Laus 1980;Kotz et al 1989) but as yet no doubts have been expressed about autoclaving as a safe method for devitalising bone tumours (Enneking and Flynn 1969). Kà ¶hleret at (1986) demonstrated the rapid penetration of heat into the diaphyseal bones of rabbits during autoclaving at 121°Cfor 20 minutes and at 13 1°Cfor two minutes, respectively, and concluded that the method can be used safely for uniform and complete sterilisation of entire specimens.…”

Examination and evaluation of surgical margins in bone tumours

“…Enneking, Heise et al and Kotz et al have described the close relationship between the width of the surgical margin and the incidence of local recurrence and survival [5,7,8]. They proposed a margin of 4 cm to 5 cm of normal tissue in wide or radical resections.…”

Distal Femoral Resection with Endoprosthetic Reconstruction

“…malignant fibrous histiocytoma, fibrosarcoma, and malignant giant cell tumors). [1][2][3][4][5][6][7][8] Almost all low-grade sarcomas of the distal femur, especially parosteal osteosarcoma and chondrosarcoma, can be treated safely with a limb-sparing resection. Careful preoperative planning and patient selection are crucial to a successful outcome.…”

“…[1][2][3][4][5] The continuous disease-free survival rates in patients who have undergone resection are the same as or better than those of patients undergoing amputation; presumably because of the use of appropriate selection criteria. Eckardt et al 6 reported their experience at the University of California at Los Angeles with Stage IIB osteosarcoma for the period 1972-84.…”