Surgical management of advanced gastric cancer: An evolving issue

Marano, Luigi; Połom, Karol; Patriti, Alberto; Roviello, Giandomenico; Falco, Giuseppe; Stracqualursi, A; Luca, Raffaele De; Petrioli, Roberto; Martinotti, Mario; Generali, Daniele; Marrelli, Daniele; Martino, Natale Di; Roviello, Franco

doi:10.1016/j.ejso.2015.10.016

Cited by 77 publications

(54 citation statements)

References 81 publications

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“…Surgical resection with extended lymph node clearance remains the only curative option for non-metastatic gastric cancer [3–5]. Although with the significant improvement in surgical techniques and adjuvant therapy, the prognosis of gastric cancer is still not promising [6]. Thus, the prognostic risk factors for gastric cancer have been widely investigated, and age, tumor location, tumor size, tumor depth and lymph node metastasis, etc.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of differentiation status in gastric cancer

et al. 2018

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BackgroundUp to date, investigation of the prognostic value of differentiation status mainly focused on signet ring cell and mucinous gastric cancer. Thus, the present study aims to investigate the clinicopathological features and prognosis of gastric cancer patients with well, moderately and poorly differentiation status.MethodsFrom September 2008 to March 2015, a total of 3090 gastric cancer patients treated with radical D2 gastrectomy were enrolled in the present study. Clinicopathological characteristics and prognosis of gastric cancer patients with well, moderately and poorly differentiation status were analyzed.ResultsThere were 2422 male (78.4%) and 668 female (21.6%). The median age was 58 (20–90) years. There were 370 (12.0%) well differentiated tumors, 836 (27.0%) moderately differentiated tumors and 1884 (61.0%) poorly differentiated tumors. Well and moderately differentiation status were associated with older age, male gender, smaller tumor, shallower invasion, less lymph node involvement and earlier tumor stage (all p < 0.001). Inversely, poorly differentiation status was associated with younger age, female gender, larger tumor, deeper invasion, more lymph node involvement and later tumor stage (all p < 0.001). With respect to prognosis, well differentiation status was associated with favorable overall survival and poorly differentiation status was associated with unfavorable overall survival (p < 0.001). However, after matching with age, tumor size, T and N stage, there was no significant difference among the overall survival of the three groups (p = 0.415).ConclusionsWell, moderately and poorly differentiation status was significantly associated with clinicopathological features of gastric cancer patients. However, it was not associated with the prognosis of gastric cancer patients.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of differentiation status in gastric cancer

et al. 2018

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“…Surgical resection with extended lymph node clearance remains the only curative option for non-metastatic gastric cancer. Despite rapid advances in surgical techniques and adjuvant therapy, the prognosis for advanced gastric cancer is still poor [2]. Precise prognostic assessment is critical for optimizing treatment decisions and improving outcomes in gastric cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Low lymphocyte-to-white blood cell ratio and high monocyte-to-white blood cell ratio predict poor prognosis in gastric cancer

et al. 2016

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Previous results regarding the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in gastric cancer are conflicting, and full analysis of other blood test parameters are lacking. We therefore examined the associations between various blood test parameters and prognosis in 3243 gastric cancer patients randomly divided into training (n=1621) and validation (n=1622) sets. Optimal cut-off values of 0.663 for neutrophil-to-white blood cell ratio (NWR), 0.288 for lymphocyte-to-white blood cell ratio (LWR), 0.072 for monocyte-to-white blood cell ratio (MWR), 2.604 for NLR, 0.194 for monocyte-to-lymphocyte ratio (MLR), and 130.675 for PLR were identified in the training set. Univariate and survival analyses revealed that high NWR, low LWR, high MWR, high NLR, high MLR, and high PLR are all associated with a poor prognosis in gastric cancer. However, multivariate analysis revealed that only LWR, and MWR are independent prognostic predictors, and prognostic value increased when LWR and MWR were considered in combination. These findings suggest that low LWR and high MWR are each predictive of a poor prognosis, and exhibit greater prognostic value when considered in combination.

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“…This aspect differs from the implementation of screening programs for gastric cancer, especially in Asia, which has contributed to the diagnosis of the disease in the early stages and therefore increased the survival of these patients, thus generating better results than those obtained in the West, in relation to the same disease 19 .…”

Section: Discussionmentioning

confidence: 98%

“…It is noteworthy that, although screening programs are capable of increasing the diagnostic capacity of oncological disease 18 - 19 , different from that occurring in gastric tumors 19 , the scientific literature does not seem to be able to demonstrate the capacity of these initiatives to impact on the mortality associated with colorectal cancer 18 , 21 - 22 .…”

Section: Discussionmentioning

confidence: 99%

Intervening factors for the initiation of treatment of patients with stomach and colorectal cancer

Valle

Turrini

Poveda

2017

Rev. Latino-Am. Enfermagem

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Objective:to identify the time between symptoms, the request for care and the beginning of treatment in patients with stomach and colorectal cancer as well as the factors that interfere in these processes. Method:correlational descriptive study, including 101 patients diagnosed with stomach or colorectal cancer, treated in a hospital specialized in oncology. Results:the 101 patients investigated there was predominance of males, mean age of 61.7 years. The search for medical care occurred within 30 days after the onset of symptoms, in most cases. The mean total time between the onset of symptoms and the beginning of treatment ranged from 15 to 16 months, and the mean time between the search for medical care and the diagnosis was 4.78 months. The family history of cancer (p=0.008) and the implementation of preventive follow-up (p<0.001) were associated with shorter periods between the search for care and the beginning of treatment. Nausea, vomiting, hematochezia, weight loss and pain were associated with faster demand for care. Conclusion:the longer interval between the search for medical care and the diagnosis was possibly due to the non-association between the presented symptoms and the disease.

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Surgical management of advanced gastric cancer: An evolving issue

Cited by 77 publications

References 81 publications

Prognostic value of differentiation status in gastric cancer

Prognostic value of differentiation status in gastric cancer

Low lymphocyte-to-white blood cell ratio and high monocyte-to-white blood cell ratio predict poor prognosis in gastric cancer

Intervening factors for the initiation of treatment of patients with stomach and colorectal cancer

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