Surgical management and outcome of osteosarcoma patients with unilateral pulmonary metastases

Su, Wendy; Chewning, Joseph H.; Abramson, Sara J.; Rosen, Nancy; Gholizadeh, Masoumeh; Healey, John H.; Meyers, Paul A.; Quaglia, Michael P. La

doi:10.1016/j.jpedsurg.2003.11.030

Cited by 57 publications

(48 citation statements)

References 41 publications

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“…To this end, we assessed the impact of age, sex, number of metastases at first metastasectomy, maximal diameter of the tumor at first pulmonary metastasectomy, number of surgeries, and DFI on survival. In a previous systematic review of reported outcome in approximately 1,800 osteosarcoma patients with pulmonary metastases from 1939 to 2007, the main prognostic factor affecting survival was found to be complete surgical remission [1,[4][5][6]8]. In addition, DFI, as well as number and localization of metastases, has also been found to be significantly associated with survival [3,[5][6][7][9][10][11].…”

Section: Discussionmentioning

confidence: 97%

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Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Matsubara

Mori

Kinoshita

et al. 2015

Journal of Respiratory Medicine

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.Purpose. To identify prognostic factors for metastatic osteosarcoma patients and establish indication for repeat metastasectomy. Methods. Data from 37 patients with pulmonary metastasis from osteosarcoma who underwent metastasectomy in our institute from 1979 to 2013 were retrospectively reviewed. Results. Prognostic factors analyzed were age, sex, maximal diameter of the tumor at first pulmonary metastasectomy, total number of resected pulmonary metastases at first metastasectomy, number of surgeries, and disease free interval. In our analysis, characteristics associated with an increased overall survival were age > 15 years and fewer metastases (≤3). Of the 37 patients, 13 underwent repeat metastasectomy after the first metastasectomy. Of the 7 patients that underwent only two metastasectomies, three remained disease-free. In contrast, all six patients that underwent three or more metastasectomies died of relapse. Patients who had five or less lesions at second metastasectomy showed better survival compared to those who had six or more lesions. Conclusion. Age > 15 years and number of metastases at first metastasectomy were independent prognostic factors. Metastasectomy may provide curative treatment even in cases requiring repeat surgery. The number of metastases at second metastasectomy may be a potential predictor of the need for repeat surgery.

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Section: Discussionmentioning

confidence: 97%

“…Approximately 50% of patients with osteosarcoma develop synchronous or metachronous metastatic lung disease [3]. The prognosis of patients with synchronous or metachronous metastatic osteosarcoma has improved over the last two decades, with the 5-year disease-free survival rate increasing from 0-17% to 30-50% [4].…”

Section: Introductionmentioning

confidence: 99%

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Matsubara

Mori

Kinoshita

et al. 2015

Journal of Respiratory Medicine

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“…Pastorino and colleagues reviewed the longterm results after resection of pulmonary metastases from various primaries based on more than 5000 patients collected from several institutions and found that DFI of 36 months or greater and a solitary metastases were associated with improved survival. The longer the interval between resection of the primary tumor and the development of chemotherapyresistant metastases the better chance of survival [7,[14][15][16]. A shorter DFI might indicate a more aggressive neoplasm and therefore predict a shorter survival.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and long-term results of pulmonary metastasectomy for pediatric histologies☆

Tronc

Conter

Marec‐Bérard

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…In cases of metastasizing osteosarcoma in which radiology demonstrates only unilateral pulmonary lesions, it is recommended that patients undergo surgical exploration of both lungs, since palpation by an experienced thoracic surgeon is the most sensitive method for discovering even the smallest metastases that may no longer be considered viable based on histologic criteria [12,15]. An aggressive approach to the treatment of pulmonary metastases is justified when the criteria for establishing a curative intention are met [10,16].…”

Section: Indicationmentioning

confidence: 99%

Thoracic surgery in children

Kanngiesser

Liewald

Halter

et al. 2005

European Journal of Cardio-Thoracic Surgery

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Thoracic surgical procedures in children with underlying benign disease are associated with a good prognosis and high quality of life scores. Surgical treatment of pulmonary metastases is a feasible component of the overall oncologic therapy concept and can offer the only opportunity for curation for a selected group of patients. Because of high postoperative mortality, however, the indication for diagnostic thoracotomies in children with immunodeficiencies and poor general health should be weighed critically.

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Surgical management and outcome of osteosarcoma patients with unilateral pulmonary metastases

Cited by 57 publications

References 41 publications

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

Prognostic factors and long-term results of pulmonary metastasectomy for pediatric histologies☆

Thoracic surgery in children

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