Surgical decompression for traumatic spinal cord injury in a tertiary center

Ojo, OA; Poluyi, EO; Owolabi, BS; Kanu, Okezie Obasi; Popoola, MO

doi:10.4103/njcp.njcp_303_16

Cited by 12 publications

(11 citation statements)

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“…Higher mortality rate with worse Frankel grades and neurovegetative disorders ere were 18 deaths (e.g., 17.7% of all traumatic cervical spine injury (TCSI) patients: 16 deaths for Frankel A, 1 death for Frankel B, and 1 death for Frankel E) e mortality rate of Frankel Grade A exceeded 70%. e overall mortality for patients with neurovegetative disorders exceeded 75%.…”

Section: Resultsmentioning

confidence: 99%

“…[1,3,14,15,19] However, some factors lack precision or may not be easily obtained such as MRI studies which may not be available in developing countries or mechanism of trauma which may not be deduced in unconscious traumatized and without major bone or discoligamentous injury. In addition, the benefits of early surgery is unclear [17,18] and delay of surgery remains a controversial factor; indeed, some studies consider an early surgery within 24 h of injury, [7][8][9][10] other studies spread this delay to 72 h. [11][12][13]16] As the best independent prognostic factors in TCSI are the original neurological deficit, which correlate well with spinal cord damage severity, the Frankel grading system, which is simple, easily reproducible, and widely used, makes it possible to envisage the outcome according to the initial involvement.…”

Section: Discussionmentioning

confidence: 99%

“…[2] In Frankel Grades (B, C, or D), functional recovery is variable, about 85% of Grade C or D patients will recover ambulation. [2,[5][6][7][8][9][10][11][12][13][14][15][16][17] In pure radicular involvement, the prognosis is better, although sphincter disorders recover less easily.…”

Section: Discussionmentioning

confidence: 99%

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Traumatic cervical spine injury: Short-and medium-term prognostic factors in 102 patients

Abboud¹,

Ziani²,

Melhaoui³

et al. 2020

Surgical Neurology International

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Background: Traumatic cervical spine injuries (CSIs) can be defined as osteodiscoligamentous lesions and are frequent in the young and active population. These lesions are often associated with significant devastating neurological deficits. Here, we sought to establish short-and medium-term prognostic factors that could help predict future outcomes. Methods: We retrospectively reviewed 102 adults admitted for traumatic CSI over an 11-year period (January 2004–December 2014). Patients were graded using Frankel scale as exhibiting good or poor outcomes. Results: Two risk factors that significantly predicted results for CSI included original poor Frankel grades (e.g., A and B) and initial neurovegetative disorders (e.g., respectively, P = 0.019 and P = 0.001). However, we did not anticipate that two other risk factors, operative delay and mechanism of trauma, would not significantly adversely impact outcomes. Conclusion: Here, we identified two significant risk factors for predicting poor outcomes following CSI; poor initial Frankel Grades A and B and neurovegetative disorders at the time of original presentation.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Traumatic cervical spine injury: Short-and medium-term prognostic factors in 102 patients

Abboud¹,

Ziani²,

Melhaoui³

et al. 2020

Surgical Neurology International

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“…SCI is accompanied by extensive complications, such as pressure sore, urinary tract infection, spasm, paraplegia, neuralgia and pneumonia [4][5][6][7]. At present, the principle of treatment for SCI is executed drugs and hyperbaric oxygen on the basis of spinal decompression [8]. The therapeutic strategies may affect rehabilitation care and functional recovery of the patients with SCI.…”

Section: Introductionmentioning

confidence: 99%

Protocatechuic aldehyde mitigates hydrogen peroxide-triggered PC12 cell damage by down-regulating MEG3

Zhong

Yao

Luo

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Background: Protocatechuic aldehyde (PA) extracts from S. miltiorrhiza, which anti-oxidative and antiinflammatory functions have been certified in diverse diseases. Nonetheless, the influence of PA in spinal cord injury (SCI) is still hazy. The research probed the function of PA in hydrogen peroxide (H 2 O 2)damaged PC12 cells. Methods: The disparate dosages of H 2 O 2 (0-400 mM) or PA (0-2 mM) were applied for stimulating PC12 cells, and subsequently cell viability, apoptosis, apoptosis-and autophagy-correlative factors were evaluated. After pc-MEG3 transfection, functions of MEG3 overexpression in H 2 O 2 and/or PA-managed PC12 cells were reassessed. Western blot was conducted to determine Wnt/b-catenin and PTEN/PI3K/ AKT pathways. Results: H 2 O 2 stimulation clearly triggered PC12 cell damage via prohibiting cell viability and accelerating apoptosis and autophagy. But, PA management mitigated H 2 O 2-triggered PC12 cells damage. Down-regulated MEG3 triggered by PA was presented in H 2 O 2-managed cells. What's more, overexpressed MEG3 dramatically overturned the influences of PA in H 2 O 2-damaged PC12 cells. Beyond that, PA activated Wnt/b-catenin and PTEN/PI3K/AKT via repression of MEG3 in H 2 O 2-managed PC12 cells. Conclusions: The results disclosed the protective impacts of PA on PC12 cells to resist H 2 O 2-provoked damage. MEG3, Wnt/b-catenin and PTEN/PI3K/AKT pathways joined in adjusting the activity of PA in H 2 O 2-damaged PC12 cells.

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“…Spine surgery procedures are now a mainstay for the treatment of these pathologies and they serve to decompress the neural structures, stabilise the spine and correct deformity. (1)(2)(3)(4) There is an increasing ageing population worldwide and a consequent increase in the diseases that affect such a demographic. Degenerative spine diseases which occur with increasing age (5)(6)(7) are now a common pathology presenting to the clinician.…”

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confidence: 99%

Spine Surgery in Jos, Nigeria- An Initial Experience

Ode¹,

Olu²,

Amupitan³

et al. 2018

jemds

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BACKGROUND Spine pathologies are a common presentation to Orthopaedicians and Neurosurgeons and include degenerative diseases of the spine, spine tumours, traumatic spine injuries, spine infections and spine deformities. Non-operative and operative treatment modalities are employed in the treatment of these conditions. The increasing ageing population worldwide has resulted in an increase in the degenerative spine conditions presenting to the clinician. Many surgical procedures are employed in the treatment of these conditions.The aim of this study was to evaluate the procedures carried out and attendant outcomes. MATERIALS AND METHODSThis was a case series of spine surgeries carried out over a 2-year period (2015 to 2017) in hospitals in Jos Nigeria. The data was reviewed retrospectively. They were analysed for spine pathologies; operative procedures were carried out. Duration of procedures, outcomes and complications were observed. The outcome was assessed using numeric pain scale. Data was analysed using the Epi Info statistical software. RESULTS25 patients in total were operated within the said period. Ages ranged between 35 and 77 years, with a mean of 60.8 years. Maleto-female ratio was 1:1.5. Pathologies operated on were lumbar spondylosis with canal stenosis and instability 8 patients (32%), lumbar spondylosis with canal stenosis without instability 6 patients (24%), canal stenosis 4 patients (16%), severe cervical spondylosis 3 patients (12%), spondylolisthesis 2 patients (8%) and metastatic tumour spread to the spine 2 patients (8%). Operative procedures carried out were laminectomy with instrumented posterolateral fusion (PLF) 8 (56%), laminectomies and non-instrumented posterolateral fusion 9 (36%) and anterior cervical decompression and fusion (ACDF) 3 (12%). 21 patients had a reduction by 6 or more points on the numeric pain scale (84%). One patient had cerebrospinal fluid leak which was treated nonoperatively; 2 patients had superficial surgical site infection and one patient was reoperated for persistent radiculopathy and improved thereafter. CONCLUSIONSpine surgery is a safe and effective means of treating various spine pathologies with minimal risks and more of these procedures will be employed in view of the increasing number of patients with degenerative spine disease.

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Surgical decompression for traumatic spinal cord injury in a tertiary center

Cited by 12 publications

References 1 publication

Traumatic cervical spine injury: Short-and medium-term prognostic factors in 102 patients

Traumatic cervical spine injury: Short-and medium-term prognostic factors in 102 patients

Protocatechuic aldehyde mitigates hydrogen peroxide-triggered PC12 cell damage by down-regulating MEG3

Spine Surgery in Jos, Nigeria- An Initial Experience

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