Surgical Considerations for Newly Diagnosed Meningiomas

Hong, Christopher S.; Moliterno, Jennifer

doi:10.1007/978-3-030-59558-6_6

Cited by 1 publication

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“…Management of residual and recurrent lesions remains debated, with those demonstrating higher risk typically undergoing radiation and/or repeat surgical resection [63]. However, limits to the number of resections and radiation treatments patients can safely undergo necessitates more effective therapeutic options.…”

Section: Guidance Of Patient Management Decisionsmentioning

confidence: 99%

The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications

et al. 2021

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Introduction Meningiomas are generally considered “benign,” however, these tumors can demonstrate variability in behavior and a surprising aggressiveness with elevated rates of recurrence. The advancement of next-generation molecular technologies have led to the understanding of the genomic and epigenomic landscape of meningiomas and more recent correlations with clinical characteristics and behavior. Methods Based on a thorough review of recent peer-reviewed publications (PubMed) and edited texts, we provide a molecular overview of meningiomas with a focus on relevant clinical implications. Results The identification of specific somatic driver mutations has led to the classification of several major genomic subgroups, which account for more than 80% of sporadic meningiomas, and can be distinguished using noninvasive clinical variables to help guide management decisions. Other somatic genomic modifications, including non-coding alterations and copy number variations, have also been correlated with tumor characteristics. Furthermore, epigenomic modifications in meningiomas have recently been described, with DNA methylation being the most widely studied and potentially most clinically relevant. Based on these molecular insights, several clinical trials are currently underway in an effort to establish effective medical therapeutic options for meningioma. Conclusion As we enhance our multiomic understanding of meningiomas, our ability to care for patients with these tumors will continue to improve. Further biological insights will lead to additional progress in precision medicine for meningiomas.

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Section: Guidance Of Patient Management Decisionsmentioning

confidence: 99%