Surgery of the primary tumor improves survival in women with stage IV breast cancer in Southwest China

Xie, Yuxin; Lv, Xingxing; Luo, Chunying; Hu, Kejia; Xie, Keqi; Zheng, Hong

doi:10.1097/md.0000000000007048

Cited by 16 publications

(10 citation statements)

References 38 publications

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“…Our findings support the concept that DTCs may be eliminated by the innate and adaptive immune surveillance 3,9 . Although the effect of surgical resection of primary tumor on DTCs is debated, recent clinical evidence suggests that the complete resection of primary breast tumors with negative surgical margins significantly improves survival of patients 14,40 . This may also be true for other solid malignancies with clear resectable margins 41,42 .…”

Section: Discussionmentioning

confidence: 99%

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

et al. 2019

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Although clinically apparent metastasis is associated with late stages of cancer development, micro-metastatic dissemination may be an early event. However, the fate of these early disseminated tumor cells (DTC) remains elusive. We show that despite their capacity to disseminate into secondary organs, 4T1 tumor models develop overt metastasis while EMT6-tumor bearing mice clear DTCs shed from primary tumors as well as those introduced by intravenous (IV) injection. Following the surgical resection of primary EMT6 tumors, mice do not develop detectable metastasis and reject IV-injected tumor cells. In contrast, these cells readily grow and metastasize in immuno-deficient athymic or Rag2 −/− mice, an effect mimicked by CD8 + T-cell depletion in immunocompetent mice. Furthermore, recombinant G-CSF or adoptive transfer of granulocytic-MDSCs isolated from 4T1 tumor-bearing mice, induce metastasis by suppressing CD8 + T-cells in EMT6-primed mice. Our studies support the concept of immune surveillance providing molecular insights into the immune mechanisms during tumor progression.

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Section: Discussionmentioning

confidence: 99%

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

et al. 2019

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“… 4 Other studies reported that, of all breast cancer patients, 5%–10% had distant metastases at the initial presentation. 14 15 Further studies are needed to investigate the reasons for the low surgery rate and what could pose an obstacle to treatment access and compliance.…”

Section: Discussionmentioning

confidence: 99%

Nationwide Analysis of Treatment Patterns for Korean Breast Cancer Survivors Using National Health Insurance Service Data

et al. 2018

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BackgroundThe National Health Insurance Service (NHIS) established a healthcare claim database for all Korean citizens. This study aimed to analyze the NHIS data and investigate the patterns of breast cancer treatments.MethodsWe constructed a retrospective female breast cancer cohort by analyzing annual incident cases. The annual number of newly diagnosed female breast cancer was compared between the NHIS data and Korea National Cancer Incidence Database (KNCIDB). The annual treatment patterns including surgery, chemotherapy, radiation therapy, endocrine therapy and targeted therapy were analyzed.ResultsA total of 148,322 women with newly diagnosed invasive breast cancer during 2006–2014 was identified. The numbers of newly diagnosed invasive breast cancer cases were similar between the NHIS data and KNCIDB, which demonstrated a strong correlation (r = 0.995; P < 0.001). The age distribution of the breast cancer cases in the NHIS data and KNCIDB also showed a strong correlation (r = 1.000; P < 0.001). About 85% of newly diagnosed breast cancer patients underwent operations. Although the proportions of chemotherapy use have not changed during 2006–2014, the total number of chemotherapy prescriptions sharply increased during this period. The proportions of radiotherapy and anti-hormonal therapy increased. Among the anti-hormonal agents, tamoxifen was the most frequently prescribed medication, and letrozole was the most preferred endocrine treatment in patients aged ≥ 50 years.ConclusionAlong with the increased breast cancer incidence in Korea, the frequencies of breast cancer treatments have increased. The NHIS data can be a feasible data source for future research.

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“…O estudo de Sarturi et al (2012) (22) , mostrou que o subtipo basalóide (triplo negativo) esteve presente em pacientes com idade inferior a 39 anos, porém no nosso estudo a paciente que apresentou esse subtipo foi a paciente mais idosa. Conforme já apresentado em trabalho de Geyer e Nigro (12) , em nosso estudo surgiram dados semelhantes em relação a frequência dos tipos histológicos, sendo que o carcinoma ductal invasor foi o mais comum, seguido pelo misto e trazendo o carcinoma lobular invasor como menos frequente, ordem também encontrada na literatura (29)(30)(31)(32) .…”

Section: Discussionunclassified

Perfil histológico e imuno-histoquímico das pacientes com câncer de mama operadas no Hospital Santa Casa de Curitiba no período de 2014 e 2015

Raffo

Hubie

Zanini

et al. 2018

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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Objetivos: Identificar tipo histológico e perfil imuno-histoquímico das pacientes operadas por câncer de mama no Hospital Santa Casa de Curitiba. Correlacionar se os tipos histológicos mais agressivos são também de pior prognóstico imuno-histoquímico. Métodos: Estudo retrospectivo, observacional e analítico com 26 pacientes, no qual foram avaliadas as variáveis: sexo, idade, histologia, painel imuno-histoquímico (luminal A, luminal B, HER2 positivo e triplo negativo). Resultados: O sexo mais prevalente foi o feminino (96,2%), a média de idade foi 58 anos, o tipo histológico mais encontrado foi carcinoma ductal invasor (57,7%). No painel imuno-histoquímico a prevalência foi do subtipo luminal A (53,8%) seguidos pelos luminal B (30,8%), HER2 positivo (7,7%) e triplo negativo (7,7%). Na análise da relação histológica e imuno-histoquímica 57,1% dos carcinomas ductais invasores são luminais A e o carcinoma pouco diferenciado é triplo negativo. Os mistos foram distribuídos em luminal A (66,7%) e luminal B (33,3%). Os mucinosos dividiram-se igualmente em luminal A, luminal B e triplo negativo. O lobular invasor teve distribuição igual entre luminal A e B. Conclusões: O sexo feminino foi o mais prevalente, a média de idade apresentou um platô acima do encontrado na literatura, o tipo histológico mais incidente nas pacientes acompanhadas foi o carcinoma ductal invasor. No painel imuno-histoquímico a prevalência foi do subtipo luminal A, seguidos pelos luminal B, HER2 positivo e triplo negativo. Os tipos histológicos menos agressivos são mais comuns e também apresentam perfil imuno-histoquímico de melhor prognóstico e os mais agressivos são de pior prognóstico e menos responsivos aos tratamentos.

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Surgery of the primary tumor improves survival in women with stage IV breast cancer in Southwest China

Abstract: Supplemental Digital Content is available in the text

Cited by 16 publications

References 38 publications

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Nationwide Analysis of Treatment Patterns for Korean Breast Cancer Survivors Using National Health Insurance Service Data

Perfil histológico e imuno-histoquímico das pacientes com câncer de mama operadas no Hospital Santa Casa de Curitiba no período de 2014 e 2015

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