Surgery-induced changes in red blood cell and plasma lipid peroxidation, enzymatic and non-enzymatic antioxidants, and blood hematology of female rats: protective role of methylene blue and vitamin E

Yıldız, Hamit; Durmuş, Ali Said; Şimşek, Halil

doi:10.1016/j.ejogrb.2010.11.003

Cited by 12 publications

(17 citation statements)

References 34 publications

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“…After surgery, an increase in free radical activity, such as increases in superoxide anions, xanthine oxidase, and MDA levels, has been detected 16,17. A local hypoxic environment occurs in the surgical area and leads to an ischemia/reperfusion process with a resultant decrease in the levels of free radical scavengers 7,18. Prevention of adhesion formation after the restoration of free radical scavengers, such as superoxide dismutase, CAT, dimethyl sulfoxide, and allopurinol, has been observed in animal studies.…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators6,7,21 have reported that intraperitoneal administration of vitamin E immediately prior to laparotomy closure has proved to be a safe and efficient means of preventing intraperitoneal adhesions. In the present study, post-surgical adhesion formation was significantly reduced in animals treated with vitamin E, selenium or a combination of the two.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin E has interesting biological properties and activities that suggest possible applications in preventing intraperitoneal adhesions. In vitro studies have shown that vitamin E has antioxidant, anti-inflammatory, anticoagulant, and antifibroblastic effects and decreases collagen production 6,7…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of vitamin E and selenium for the prevention of intra-abdominal adhesions in rats: uterine horn models

Durmuş

Yıldız

Yaman

et al. 2011

Clinics

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OBJECTIVE:This study compares the efficacies of vitamin E and selenium, both individually and in combination, for the prevention of postoperative intra-abdominal adhesions in rats.METHODS:Forty-seven female rats were divided into five groups. The sham animals (S group, n = 7) were given only laparotomies and intraperitoneally received 0.9% NaCl (2 ml). In the 40 other rats, abrasions of the left uterine horn were performed, followed by intraperitoneal administration of either 2 ml 0.9% NaCl (C group), 10 mg vitamin E (vitamin E group), 0.2 mg/kg selenium (Se group) or 10 mg vitamin E with 0.2 mg/kg selenium (vitamin E + Se group), with 10 animals in each treatment group.RESULTS:Adhesion formation was significantly reduced in animals in the Se and vitamin E + Se groups (p<0.05). Tissue catalase and glutathione peroxidase activities did not significantly differ between the groups. However, catalase and glutathione peroxidase activities and reduced glutathione levels were slightly increased in the vitamin E, Se and vitamin E + Se groups. In the vitamin E group, malondialdehyde concentrations were significantly lower than in the C group (p<0.05), but no significant differences were present among the S, C, Se and vitamin E + Se groups. Levels of nitric oxide were significantly higher in the C group than in the other groups (p<0.01).CONCLUSION:Intraperitoneal administration of selenium or combined vitamin E and selenium appears to be effective in preventing intra-abdominal adhesion formation in rat models through the reduction of lipid peroxidation products.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Efficacy of vitamin E and selenium for the prevention of intra-abdominal adhesions in rats: uterine horn models

Durmuş

Yıldız

Yaman

et al. 2011

Clinics

Self Cite

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“…In this regard, restoration of free radical scavengers was suggested as a treatment model in prevention of intraperitoneal adhesion formation in animal studies [4]. Many drugs and substances have been used in an attempt to decrease the risk of postoperative intra-abdominal adhesion formation in animal models [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Inflammatory response and especially reactive oxygen species (ROS) are held responsible for adhesion formation after an operation. Ischemia/reperfusion in the surgical site results in decreased levels of free radical scavengers, leading to diminished clearance of ROS [4]. …”

Section: Introductionmentioning

confidence: 99%

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

Ağaçayak

Tunç

İçen

et al. 2015

Gynecol Obstet Invest

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Aim: The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model. Material and Method: This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way. Results: Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008). Conclusion: Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.

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The effect of alpha lipoic acid on uterine wound healing after primary cesarean section: a triple-blind placebo-controlled parallel-group randomized clinical trial

Sammour

Elkholy

Rasheedy

et al. 2018

Arch Gynecol Obstet

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Surgery-induced changes in red blood cell and plasma lipid peroxidation, enzymatic and non-enzymatic antioxidants, and blood hematology of female rats: protective role of methylene blue and vitamin E

Cited by 12 publications

References 34 publications

Efficacy of vitamin E and selenium for the prevention of intra-abdominal adhesions in rats: uterine horn models

Efficacy of vitamin E and selenium for the prevention of intra-abdominal adhesions in rats: uterine horn models

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

The effect of alpha lipoic acid on uterine wound healing after primary cesarean section: a triple-blind placebo-controlled parallel-group randomized clinical trial

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