Surgery for ulcerative colitis

Vella, Mark; Masood, Muaaz; Hendry, Wilson S.

doi:10.1016/s1479-666x(07)80088-6

Cited by 5 publications

(1 citation statement)

References 68 publications

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“…The absolute contra-indications are carcinoma in the low rectum requiring a total anorectal excision, incompetent anal sphincter, and emergency presentation. Patients presenting as an emergency should be treated with a colectomy and ileostomy with preservation of the rectum [154]. A period of at least 3 months should elapse before undertaking RPC.…”

Section: Restorative Proctocolectomy For Ucmentioning

confidence: 99%

Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences

M’Koma

Moses

Adunyah

2011

Int J Colorectal Dis

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Background Colorectal cancer (CRC), the most lethal long-term complication of inflammatory bowel disease (IBD), is the culmination of a complex sequence of molecular and histologic derangements of the colon epithelium that are initiated and at least partially sustained by prolonged chronic inflammation. Dysplasia, the earliest histologic manifestation of this process, plays an important role in cancer prevention by providing the first clinical alert that this sequence is under way and by serving as an endpoint in colonoscopic surveillance of patients at high risk for CRC. Restorative proctocolectomy (RPC) is indicated for patients with IBD, specifically for ulcerative colitis that is refractory to medical treatment, emergency conditions, and/or in case of neoplastic transformation. Even after RPC with mucosectomy, pouch-related carcinomas have recently been reported with increasing frequency since the first report in 1984. We review IBD-associated CRC and pouch-related neoplasia prevalence, adverse events, risk factors, and surveillances. Methods Literature of IBD-associated CRC patients and those undergoing RPC surgeries through 2010 were prospectively reviewed. Results We found 12 studies from retrospective series and 15 case reports. To date, there are 43 reported cases of pouch-related cancers. Thirty-two patients had cancer in the anal transit zone (ATZ); of these, 28 patients had mucosectomy. Eleven patients had cancer found in the pouch body. Conclusion RPC with mucosectomy does not necessarily eliminate risks. There is little evidence to support routine surveillance of pouch mucosa and the ATZ except for patients associated with histological type C changes, sclerosing cholangitis, and unremitting pouchitis.

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Section: Restorative Proctocolectomy For Ucmentioning

confidence: 99%