Surgery for elderly patients with resectable pancreatic cancer, a comparison with non-surgical treatments: a retrospective study outcomes of resectable pancreatic cancer

Park, Hyeong Min; Park, Sang-Jae; Han, Sung‐Sik; Kim, Seong Hoon

doi:10.1186/s12885-019-6255-3

Cited by 26 publications

(28 citation statements)

References 28 publications

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“…The results proved that the overall survival of elderly patients was signi cantly shorter than the younger (14.68 months vs. 18.83 months, P < 0.001), while age is not the independent risk factor for elderly PDAC patients undergoing PD. This result was in agreement with some previous studies [16][17][18].…”

Section: Discussionsupporting

confidence: 94%

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A Time-Trend Survival Analysis of Elderly Resectable Pancreatic Cancer Patients

Jiang

Shang

et al. 2021

Preprint

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Background: The time-trend in the survival of elderly pancreatic cancer patients was still unclear. Thus, the aim of this study was to compare the survival benefit of young and elderly pancreatic cancer patients by a time-trend analysis. Methods: From 2004-2013, we obtained 5,341 of young patients (< 80 years) and 569 elderly patients (≥ 80 years) from the Surveillance, Epidemiology, and End Results (SEER) database, and the overall survival of these patients were analyzed by Kaplan-Meier estimator. The independent factors which could predict the survival of patients were determined by cox proportional hazards model.Results: We observed that the median overall survival of the young patients in 2004-2008 cohort was significantly (P < 0.001) increased when compared to that in the 2009-2013 cohort. However, we did not observe the survival benefit for the elderly patients. The Cox proportional hazards model demonstrated that the tumor size, lymph node ratio, grade, and AJCC TNM stage were independent factors of survival. Conclusions: This study demonstrated that compared to 2004-2008, the survival of elderly patients in 2009-2013 was not significantly improved. Thus, the clinicians still need to administer more care to elderly patients.

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Section: Discussionsupporting

confidence: 94%

“…For example, Park et al demonstrated that surgical resection signi cantly increased the survival of elderly patients when compared to non-surgical resection patients [18].…”

Section: Discussionmentioning

confidence: 99%

A Time-Trend Survival Analysis of Elderly Resectable Pancreatic Cancer Patients

Jiang

Shang

et al. 2021

Preprint

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“…In this study, aging itself was not an independent prognostic factor, and the non-frail elderly group showed comparable outcomes compared with the non-elderly group. Recently, the number of reports insisting that pancreatic resection of PDAC can be performed safely on older patients with acceptable risks is increasing [ 26 ]. However, frailty is a prognostic factor in several cancers [ 1 ], as shown in the present study.…”

Section: Discussionmentioning

confidence: 99%

Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma

et al. 2021

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Background Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. Methods One hundred and twenty patients who underwent pancreatic resection for pancreatic ductal adenocarcinoma were enrolled. Frailty was defined as a clinical frailty scale score ≥4. Patients were divided into frailty (n = 29) and non-frailty (n=91) groups, and clinicopathological factors were compared between the two groups. Results The frailty group showed an older age, lower serum albumin concentration, lower prognostic nutritional index, larger tumor diameter, and higher rate of lymph node metastasis than the non-frailty group (p < 0.05). Neutrophil–lymphocyte ratio and modified Glasgow prognostic score tended to be higher in the frailty group. Cancer-specific and disease-free survival rates were significantly poor in the frailty group (p < 0.05). With a multivariate analysis, frailty was an independent prognostic factor of cancer-specific survival. Conclusions Frailty can predict the prognosis of patients with pancreatic ductal adenocarcinoma who undergo pancreatic resection.

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“…As a highly malignant tumor, pancreatic cancer (PC) is the fourth leading cause of tumor-related death and is expected to become the second leading cause by 2030 in the US [ 3 , 4 ]. Due to the lack of clinical manifestations in the early stage, most PC patients are diagnosed at an advanced stage accompanied by metastasis [ 5 , 6 ]. Although the overall incidence of PC among all age groups is only 11.7 percent, the incidence of PC is 66.4 percent in patients over 65 years old and 91.1 percent in patients over 80 years old [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognostic factors of elderly patients with metastatic pancreatic cancer: a population-based study

Luan

et al. 2021

Aging

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The aim of this study was to evaluate the clinical features and prognostic factors of elderly patients with metastatic pancreatic cancer. Patients diagnosed with metastatic pancreatic cancer between 2004 and 2014 were identified from the Surveillance Epidemiology and End Results database. Clinical characteristics and prognostic factors in elderly patients with metastatic pancreatic cancer were examined. A total of 10784 metastatic pancreatic cancer patients between 65 and 80 years old were included and divided into three age groups. Elderly metastatic pancreatic cancer patients differed from younger patients in many aspects, including marital status, race, sex, T stage, N stage, treatment regimen, prognosis, cause of death, and metastatic characteristics (P<0.001). An analysis of prognostic factors showed that chemotherapy, as the main treatment for elderly patients, can significantly improve prognosis, while surgery can improve the prognosis of patients between 65 and 80 years old. Other factors, including sex, marital status, T stage, and site of metastasis, had different effects on patients in different age groups. Elderly patients with metastatic pancreatic cancer are a special group of individuals whose clinical characteristics and prognostic factors are different from those of younger patients, and these patients require special treatment and attention.

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Surgery for elderly patients with resectable pancreatic cancer, a comparison with non-surgical treatments: a retrospective study outcomes of resectable pancreatic cancer

Cited by 26 publications

References 28 publications

A Time-Trend Survival Analysis of Elderly Resectable Pancreatic Cancer Patients

A Time-Trend Survival Analysis of Elderly Resectable Pancreatic Cancer Patients

Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma

Clinical features and prognostic factors of elderly patients with metastatic pancreatic cancer: a population-based study

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