Surfeit Locus Protein 4 as a Novel Target for Therapeutic Intervention in Cerebral Ischemia–Reperfusion Injury

Hu, Wenjie; Kong, Xiangyi; Cui, Yu; Wang, Hui; Gao, Jingchen; Wang, Xiyuran; Chen, Shujun; Li, Xiaohua; Li, Shifang; Che, Fengyuan; Wan, Qi

doi:10.1007/s12035-023-03687-z

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…Longa grading: 0, no evident impairments; 1, inability to stretch out the left front paw; 2, leftward circling; 3, tendency to topple to the left; 4, a lack of spontaneous movement. Rats scoring between 1 and 3 points were selected for further experiments (Hu, Kong, et al., 2023).…”

Section: Methodsmentioning

confidence: 99%

Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury

Wang,

Ma,

et al. 2024

The Journal of Physiology

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Non‐invasive transcranial direct‐current stimulation (tDCS) is a safe ischaemic stroke therapy. Cathodal bilateral tDCS (BtDCS) is a modified tDCS approach established by us recently. Because selenium (Se) plays a crucial role in cerebral ischaemic injury, we investigated whether cathodal BtDCS conferred neuroprotection via regulating Se‐dependent signalling in rat cerebral ischaemia–reperfusion (I/R) injury. We first showed that the levels of Se and its transport protein selenoprotein P (SEPP1) were reduced in the rat cortical penumbra following I/R, whereas cathodal BtDCS prevented the reduction of Se and SEPP1. Interestingly, direct‐current stimulation (DCS) increased SEPP1 level in cultured astrocytes subjected to oxygen‐glucose deprivation reoxygenation (OGD/R) but had no effect on SEPP1 level in OGD/R‐insulted neurons, indicating that DCS may increase Se in ischaemic neurons by enhancing the synthesis and secretion of SEPP1 in astrocytes. We then revealed that DCS reduced the number of injured mitochondria in OGD/R‐insulted neurons cocultured with astrocytes. DCS and BtDCS prevented the reduction of the mitochondrial quality‐control signalling, vesicle‐associated membrane protein 2 (VAMP2) and syntaxin‐4 (STX4), in OGD/R‐insulted neurons cocultured with astrocytes and the ischaemic brain respectively. Under the same experimental conditions, downregulation of SEPP1 blocked DCS‐ and BtDCS‐induced upregulation of VAMP2 and STX4. Finally, we demonstrated that cathodal BtDCS increased Se to reduce infract volume following I/R. Together, the present study uncovered a molecular mechanism by which cathodal BtDCS confers neuroprotection through increasing SEPP1 in astrocytes and subsequent upregulation of SEPP1/VAMP2/STX4 signalling in ischaemic neurons after rat cerebral I/R injury. imageKey points Cathodal bilateral transcranial direct‐current stimulation (BtDCS) prevents the reduction of selenium (Se) and selenoprotein P in the ischaemic penumbra. Se plays a crucial role in cerebral ischaemia injury. Direct‐current stimulation reduces mitochondria injury and blocks the reduction of vesicle‐associated membrane protein 2 (VAMP2) and syntaxin‐4 (STX4) in oxygen‐glucose deprivation reoxygenation‐insulted neurons following coculturing with astrocytes. Cathodal BtDCS regulates Se/VAMP2/STX4 signalling to confer neuroprotection after ischaemia.

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Section: Methodsmentioning

confidence: 99%

Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury

Wang,

Ma,

et al. 2024

The Journal of Physiology

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“…Zhigang He (22 documents), from Harvard University, is the most prolific author, who is mainly devoted to investigating effective and translatable axon regeneration methods for nervous injuries (Cartoni et al, 2017;Norsworthy et al, 2017;Jacobi et al, 2022), indicating that research on PTEN in axon (Ning et al, 2004;Liu B et al, 2010;Kong et al, 2022). Prof. Wan revealed a series of comprehensive neuroprotective mechanisms mediated by PTEN-related pathways in brain injuries and neurodegenerative diseases, making PTEN-mediated neuronal death another popular research topic (Chang et al, 2007;Hu et al, 2023;Kong et al, 2023). Next, we set the threshold to four studies and analysed the authors who met the criteria (Figure 5).…”

Section: Co-authorship Of Authorsmentioning

confidence: 99%

Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration

Zhang,

Tan,

Wang

et al. 2024

Front. Aging Neurosci.

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Phosphatase and tensin homologue deleted on chromosome ten (PTEN) was initially recognized as a significant regulator of cancer suppression and could impede cancer cell survival, proliferation, and energy metabolism. PTEN is highly expressed in neurons and performs crucial functions in neurogenesis, synaptogenesis, and neuronal survival. Disruption of PTEN activity may also result in abnormal neuronal function and is associated with various neurological disorders, including stroke, seizures, and autism. Although several studies have shown that PTEN is involved in the development and degenerative processes of the nervous system, there is still a lack of in-depth studies that summarize and analyse patterns of cooperation between authors, institutions, countries, and journals, as well as research hotspots and trends in this important field. To identify and further visualize the cooperation and comprehend the development and trends of PTEN in the nervous system, especially in neural development and neurological diseases, we used a bibliometric analysis to identify relevant publications on this topic. We first found that the number of publications displayed a growing trend with time, but this was not stable. Universities, institutions, and authors from the United States are leading in this area of research. In addition, many cutting-edge research results have been discovered, such as key regulatory molecules and cellular mechanisms of PTEN in the nervous system, which may provide novel intervention targets and precise therapeutic strategies for related pathological injuries and diseases. Finally, the literature published within the last 5 years is discussed to identify future research trends regarding PTEN in the nervous system. Taken together, our findings, analysed using bibliometrics, may reflect research hotspots and trends, providing a reference for studying PTEN in the nervous system, especially in neural development and neurological diseases. These findings can assist new researchers in developing their research interests and gaining basic information. Moreover, our findings also may provide precise clinical guidelines and strategies for treating nervous system injuries and diseases caused by PTEN dysfunction.

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Surfeit Locus Protein 4 as a Novel Target for Therapeutic Intervention in Cerebral Ischemia–Reperfusion Injury

Cited by 2 publications

References 53 publications

Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury

Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury

Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration

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