Surfactant Protein Genetic Marker Alleles Identify a Subgroup of Tuberculosis in a Mexican Population

Abstract

Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)-A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin-skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin-skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A(3), 6A(4), and B1013_A and protective AAGG_1, and AAGG_7 marker alleles were observed. Moreover, interactions were seen between alleles 6A(2) and 1A(3) (P=.0064) and between 1A(3) and B1013_A (P=. 036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.

Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals

“…Genetic variation in SP-B has been linked to COPD in several association studies [3,9,16,18] and, thus, could have importance for the development of COPD in the general population. We determined whether three functional polymorphisms in SP-B were associated with poor lung function and COPD in a large homogenous Danish population sample.…”

“…As variations in SP-B have been associated with respiratory diseases other than COPD [9,10,25], we also tested for association between the three polymorphisms and risk of common pulmonary diseases, such as asthma, pneumonia and lung cancer. We found no consistent association between SP-B genotypes and any of the lung diseases we examined, except for asthma.…”

“…It is important for the formation of lamellar bodies and correct assembly of the surfactant layer [7]. Lack of SP-B cause fatal respiratory distress syndrome in newborns [8], and genetic markers in and around the SP-B gene have been associated with a spectrum of pulmonary diseases, including COPD [2][3][4][9][10][11][12][13]. Three functional polymorphisms in SP-B, rs1130866, rs2077079 and rs3024791, have been associated with risk and/or severity of COPD.…”

A study of collectin genes in spontaneous preterm birth reveals an association with a common surfactant protein D gene polymorphism

“…In the Finnish population, term-born young children carrying the SFTPD codon 31 methionine allele were shown to be predisposed to severe respiratory syncytial virus infection (20). In other studies, the alternative allele, threonine, was overrepresented in patients with tuberculosis in a Mexican population (21) and in those with allergic rhinitis in a Chinese population (22). This further suggests that genetic susceptibility depends on the specific ligand that causes the inflammatory challenge.…”

Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health

“…In a recent study, a decrease in SP-A content was observed with increasing age in bronchial lavage, but not in alveolar lavage (7). Moreover, SP-A genetic variant associations with various lung diseases, including RDS (15,66), RSV (52), IPF (71), and tuberculosis (17), have also been reported.…”