Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients

Seifart, Carola; Seifart, Ulf; Plagens, Alexandra; Wolf, M.; Wichert, P. von

doi:10.1038/sj.bjc.6600353

Cited by 20 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results support that of Seifart et al [2002b] who studied the polymorphism of the SP-B intron-4 in German patients with lung cancer and concluded that the SP-B variants may enhance susceptibility to developing squamous cell carcinoma of the lung [Seifart et al, 2002b]. However, the SP-B variants appear to strongly, enhance the susceptibility to the development of SCC in workers who are exposed to chromate-related processes.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers

et al. 2006

View full text Add to dashboard Cite

These findings indicate a very strong association of the SP-B intron-4 variants with mechanisms that may enhance lung cancer susceptibility, especially in workers who are employed in chromate industry. Moreover, confirmation of such results may help to suggest adding the SP-B intron-4 typing to be one of the screening tests of the pre-placement medical examination to confirm that the worker has no variations of the SP-B gene before being engaged in a chromium-related industry, with the intention of providing proper medical counseling.

show abstract

Section: Discussionsupporting

confidence: 82%

“…Different polymorphisms within the SP-B gene have been described Lin et al, 1999]. Seifart et al [2002b] studied a polymorphism of the SP-B intron-4 and concluded that the Sp-B intron-4 variants may enhance susceptibility to squamous cell carcinoma (SCC) of the lung in German patients.…”

Section: Introductionmentioning

confidence: 99%

Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers

et al. 2006

View full text Add to dashboard Cite

show abstract

“…As variations in SP-B have been associated with respiratory diseases other than COPD [9,10,25], we also tested for association between the three polymorphisms and risk of common pulmonary diseases, such as asthma, pneumonia and lung cancer. We found no consistent association between SP-B genotypes and any of the lung diseases we examined, except for asthma.…”

Section: Discussionmentioning

confidence: 99%

Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals

Bækvad-Hansen¹,

Nordestgaard²,

Dahl³

2010

Eur Respir J

View full text Add to dashboard Cite

The surfactant protein (SP)-B gene may influence chronic obstructive pulmonary disease (COPD) and, thus, personalised medicine. We tested whether functional polymorphisms in SP-B (rs1130866 (1580T.C), rs2077079 (-18A.C) and rs3024791 (-384G.A)) associate with reduced lung function and risk of COPD in the general population.We genotyped 10,231 individuals from the general adult Danish population, and recorded spirometry and hospital admissions due to COPD. Because we previously found an association between the rare SP-B 121ins2 mutation and COPD among smokers, we stratified the analyses for smoking status.None of the individual SP-B genotypes or genotype combinations were associated with reduced forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % pred and FEV1/ FVC overall or among smokers (p50.25-0.99). The odds ratio for spirometrically defined COPD did not differ from 1.0 for any of the SP-B genotypes or genotype combinations overall or among smokers (p50.17-0.78). Similar results were obtained for hospitalisation due to COPD (p50.07-0.93); we could exclude overall hazard ratios for heterozygotes of 1.18-1.21 and for homozygotes of 1.25-1.57 or larger for all three polymorphisms.In conclusion, the functional rs1130866, rs2077079 and rs3024791 polymorphisms in the SP-B gene are not associated with reduced lung function or risk of COPD, making it unlikely that these variants will be useful in personalised medicine.

show abstract

“…Moreover, the level of methylation, for two out of 11 CpGs studied, appeared, in normal lung tissue, to correlate with SP-A1 and SP-D gene expression. The present data together with the genetic association of surfactant protein genes with lung cancer (24,31,32) indicate that surfactant proteins may contribute to lung cancer genetically and epigenetically.…”

Section: Discussionmentioning

confidence: 93%

“…SP-B and SP-C play a key role in the surface tension lowering activity of surfactant, and SP-A and SP-D are important for the host defense function of the lung. Genetic variants of these genes have been associated with inflammatory lung diseases, such as respiratory distress syndrome (RDS), acute RDS (ARDS), chronic obstructive pulmonary disease (COPD), and lung cancer (19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

DNA methylation markers of surfactant proteins in lung cancer

et al. 2007

View full text Add to dashboard Cite

Abstract. Surfactant proteins play important roles in lung surfactant function and innate immunity. The DNA methylation state of 11 CpG sites of surfactant protein (SP)-A1, -B, -C, and -D was determined using universal bead arrays. A total of 90 cancerous and non-cancerous tissues from 23 patients with adenocarcinoma and 22 with squamous cell carcinoma were studied. These were divided into a training set and a testing set. The results indicate that DNA methylation profiling of these CpGs is associated with lung cancer. Four CpG sites, SP-A1_370, SP-A1_1080, SP-D_1170, and SP-D_1370, were hypomethylated in cancer and were significantly associated with both adenocarcinoma and squamous cell carcinoma, indicating that they have the potential to be used as biomarkers for lung cancer diagnosis and treatment. Normal lung tissues with a higher level of unmethylated SP-A1_1468 and SP-D_1170 CpG exhibited a higher level of SP-A1 and SP-D gene transcripts indicating that CpG methylation may play a role in gene expression. When the non-cancerous tissues were compared to cancerous tissues in patients with adenocarcinoma, the methylation profile results of these 46 samples (23 cancerous and 23 non-cancerous) could be clustered into 4 groups by agglomerative nesting. The percentage of tumor samples in each group was 0, 58, 91, and 100, respectively. A similar pattern was observed in squamous cell carcinoma patients. We speculate that SP-A1 and SP-D are subject to methylation/demethylation regulatory mechanisms and are involved in lung cancer pathogenesis by virtue of their function in innate host defense and/or regulation of inflammation.

show abstract

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients

Cited by 20 publications

References 37 publications

Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers

Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers

Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals

DNA methylation markers of surfactant proteins in lung cancer

Contact Info

Product

Resources

About