Surfactant protein B gene variations and susceptibility to lung cancer in chromate workers

Abstract

These findings indicate a very strong association of the SP-B intron-4 variants with mechanisms that may enhance lung cancer susceptibility, especially in workers who are employed in chromate industry. Moreover, confirmation of such results may help to suggest adding the SP-B intron-4 typing to be one of the screening tests of the pre-placement medical examination to confirm that the worker has no variations of the SP-B gene before being engaged in a chromium-related industry, with the intention of providing proper medical counseling.

Linguistic recognition system for identification of some possible genes mediating the development of lung adenocarcinoma

“…2 supports this fact. This result along with some earlier investigations [9,51,26,41] ensures that these genes may be responsible to develop tumor cells in lung.…”

No Association between Coding Polymorphism within Exon 4 of the Human Surfactant Protein B Gene and Pulmonary Function in Healthy Men

“…instead of a C nucleotide within codon 121 of the gene, is associated with fatal respiratory distress in neonates [18], and variation within intron 4 has been associated with susceptibility to lung cancer in chromate workers [19]. Indeed this latter point has led the authors to speculate that typing for intron 4 variants might be a useful screening procedure that could be employed before permitting individuals to work in the chromium industry [19].…”

“…Indeed this latter point has led the authors to speculate that typing for intron 4 variants might be a useful screening procedure that could be employed before permitting individuals to work in the chromium industry [19]. Furthermore, using transcript analysis and ELISA, investigators have recently reported that the C allele of the C/A (-18) promoter polymorphism influences the amount of SFPB 4 detectable in bronchoalveolar lavage [20].…”

Genetics in the workplace: implications for occupational safety and health.

“…Lung cancer Ewis et al [2006] large scale SNP platforms are capable of discovering loci associated with relative risks too modest to detect through smaller studies [Hunter et al 2007]. However, genome-wide association studies with regard to common variants and disease have only moderate predictive power and collectively only explain a small fraction of the genetic component of a disease [Goldstein 2009;Kraft and Hunter 2009].…”