Surfactant-induced cell toxicity and cell lysis

Partearroyo, M.Aránzazu; Ostolaza, Helena; Goñi, Félix M.; Barberá‐Guillem, Emilio

doi:10.1016/0006-2952(90)90399-6

Cited by 116 publications

(70 citation statements)

References 21 publications

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“…This is evidenced by the fact that developed, abnormal larvae were virtually nonexistent; during endpoint evaluation, observers either found fully developed, normal larvae or embryos that had been arrested at the multicell stage, often appearing as only loose aggregations of cells. These observations are consistent with known effects of surfactants on biomembranes, e.g., increased permeability, loss of barrier function, osmotic imbalance (Benoit et al, 1987;Partearroyo et al, 1990). Also, the occurrence of several pathological abnormalities in developing embryos has been reported in marine echinoderms and other gastropods (Tanaka, 1976;Render, 1990).…”

Section: Discussionsupporting

confidence: 84%

Comparison of Acute Aquatic Effects of the Oil Dispersant Corexit 9500 with Those of Other Corexit Series Dispersants

Singer

George

Jacobson

et al. 1996

Ecotoxicology and Environmental Safety

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Section: Discussionsupporting

confidence: 84%

Comparison of Acute Aquatic Effects of the Oil Dispersant Corexit 9500 with Those of Other Corexit Series Dispersants

Singer

George

Jacobson

et al. 1996

Ecotoxicology and Environmental Safety

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“…For HeLa cells, lethal levels of surfactants coincided with surface tensions of 45 dynes/cm or below [20]. The cell-surfactant interaction for B16 melanoma cells is reported to be highly dependent on the CMC [21], where loss of cell viability occurs at surfactant concentrations below the CMC, but cell lysis only occurs at or near the CMC. Furthermore, the concentrations producing a 50% decrease in cell viability were clearly CMC-linked and always below that critical value.…”

Section: Discussionmentioning

confidence: 97%

A limitation of the microtox® test for toxicity measurements of nonionic surfactants

Sherrard

Marriott

McCormick

et al. 1996

Enviro Toxic and Chemistry

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Abstract-The Microtox" test was successfully used to measure EC50 values of nonionic polyethoxylate surfactants. However, toxicity measurements of real samples that contain surfactants above a particular concentration, termed the critical toxicity concentration (CTC) are not valid. These samples require dilution before the test is performed, and because the relationship between toxicity and concentration is not linear above the CTC, the EC50 cannot be extrapolated back to give the toxicity of the original concentrated sample and a true estimation of toxicity is therefore not possible. This phenomenon may be related to the minimum surface tension requirement of the bacteria or other physical properties of the surfactant such as the tendency to assemble at interfaces and surfaces and the tendency to form micelles.

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“…Such effects are dependent on both absolute concentration and surfactant-lipid molar ratios. At low surfactant concentrations, membranes lose their barrier capacity, greatly increasing permeability (28), while at higher concentrations, generally above the critical micelle concentration, cell lysis occurs (29). Thus, the overall effect of a surfactant on membrane permeability is the result of 2 opposing events, interaction with the membrane and that of the permeant with the micelle (30).…”

Section: Effects Of Surfactants On the Skinmentioning

confidence: 99%

Surfactants and experimental irritant contact dermatitis

1995

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Surface-active agents (surfactants) are characterized by the possession of 2 different moieties, both polar and non-polar regions on the same molecule. Surfactants are broadly classified as anionic, cationic, amphoteric, or non-ionic, according to the nature of the hydrophile yielded in aqueous solution. In currently marketed household, personal, and industrial cleaners, anionic surfactants are the most common class because of their relative ability to solubilize fats and oils, lower the surface tension of aqueous solutions, or form microemulsions. Many surfactants elicit irritant reactions when applied to the skin, partially due to their relative ability to solubilize lipid membranes. Hence, surfactants have become important implements in skin irritation investigations. In general, the physicochemical properties of surfactants are a crucial factor in eliciting skin irritation. Anionic surfactants are broadly accepted as potent irritants to human and animal skin. Cationic surfactants are reputedly at least equally irritating, but more cytotoxic than anionic, while the irritation potential of non-ionic surfactants is considered the lowest. Such classification of innumerable surfactants is convenient and held in high practical esteem. However, the categorization does not permit the exact determination of irritation and cytotoxicity potential of each surfactant. Ranking of surfactant skin irritancy and cytotoxicity obtained by both in vitro and in vivo assays provides a helpful orientation for future work.Key words: anionic, cationic, amphoteric, non-ionic surfactants; skin irritation; in vivo skin irritation test; in vitro cytotoxicity assays; ranking of surfactant skin irritancy. © Munksgaard, 1995.

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Surfactant-induced cell toxicity and cell lysis

Cited by 116 publications

References 21 publications

Comparison of Acute Aquatic Effects of the Oil Dispersant Corexit 9500 with Those of Other Corexit Series Dispersants

Comparison of Acute Aquatic Effects of the Oil Dispersant Corexit 9500 with Those of Other Corexit Series Dispersants

A limitation of the microtox® test for toxicity measurements of nonionic surfactants

Surfactants and experimental irritant contact dermatitis

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