1990
DOI: 10.1016/0006-2952(90)90399-6
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Surfactant-induced cell toxicity and cell lysis

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Cited by 115 publications
(67 citation statements)
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“…This is evidenced by the fact that developed, abnormal larvae were virtually nonexistent; during endpoint evaluation, observers either found fully developed, normal larvae or embryos that had been arrested at the multicell stage, often appearing as only loose aggregations of cells. These observations are consistent with known effects of surfactants on biomembranes, e.g., increased permeability, loss of barrier function, osmotic imbalance (Benoit et al, 1987;Partearroyo et al, 1990). Also, the occurrence of several pathological abnormalities in developing embryos has been reported in marine echinoderms and other gastropods (Tanaka, 1976;Render, 1990).…”
Section: Discussionsupporting
confidence: 84%
“…This is evidenced by the fact that developed, abnormal larvae were virtually nonexistent; during endpoint evaluation, observers either found fully developed, normal larvae or embryos that had been arrested at the multicell stage, often appearing as only loose aggregations of cells. These observations are consistent with known effects of surfactants on biomembranes, e.g., increased permeability, loss of barrier function, osmotic imbalance (Benoit et al, 1987;Partearroyo et al, 1990). Also, the occurrence of several pathological abnormalities in developing embryos has been reported in marine echinoderms and other gastropods (Tanaka, 1976;Render, 1990).…”
Section: Discussionsupporting
confidence: 84%
“…For HeLa cells, lethal levels of surfactants coincided with surface tensions of 45 dynes/cm or below [20]. The cell-surfactant interaction for B16 melanoma cells is reported to be highly dependent on the CMC [21], where loss of cell viability occurs at surfactant concentrations below the CMC, but cell lysis only occurs at or near the CMC. Furthermore, the concentrations producing a 50% decrease in cell viability were clearly CMC-linked and always below that critical value.…”
Section: Discussionmentioning
confidence: 97%
“…Such effects are dependent on both absolute concentration and surfactant-lipid molar ratios. At low surfactant concentrations, membranes lose their barrier capacity, greatly increasing permeability (28), while at higher concentrations, generally above the critical micelle concentration, cell lysis occurs (29). Thus, the overall effect of a surfactant on membrane permeability is the result of 2 opposing events, interaction with the membrane and that of the permeant with the micelle (30).…”
Section: Effects Of Surfactants On the Skinmentioning
confidence: 99%