Surfactant-Enhanced Ultrafiltration of Heavy Metals from Waste Streams with Pilot-Scale System

Huang, Yi-Chu; Batchelor, Bill; Köseoglu, S. S.

doi:10.1089/hwm.1994.11.385

Cited by 20 publications

(4 citation statements)

References 2 publications

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“…In general, this result seems to be congruent with our notes on the evolutionary dynamics of cancer that propose a joint effect of mutations and selective forces as indispensable factors of carcinogenesis. In our interpretation, the putative selective force of local zinc deficiency would either be explained by the zinc-limiting effect of fat alone, or alternatively, by a more complex interaction that could involve inflammation or the possible relationship between deoxycholic acid and zinc 365,366 . Of interest, there exists a possible regulatory role of zinc on leptin levels 367 and there are known links between leptin and obesity 368,369 as well as between leptin and cancer 370 .…”

Section: Chemotherapeutic Agents and Resistancementioning

confidence: 83%

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

Engelken

Altmeyer

2014

Preprint

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Abstracts Abstract for ScientistsWhile decades of cancer research have firmly established multiple "hallmarks of cancer" 1,2 , cancer's genomic landscape remains to be fully understood. Particularly, the phenomenon of aneuploidy -gains and losses of large genomic regions, i.e. whole chromosomes or chromosome arms -and why most cancer cells are aneuploid remains enigmatic 3 . Another frequent observation in many different types of cancer is the deregulation of the homeostasis of the trace elements copper, zinc and iron. Concentrations of copper are markedly increased in cancer tissue and the blood plasma of cancer patients, while zinc levels are typically decreased [4][5][6][7][8][9] . Here we discuss the hypothesis that the disruption of trace element homeostasis and the phenomenon of aneuploidy might be linked. Our tentative analysis of genomic data from diverse tumor types mainly from The Cancer Genome Atlas (TCGA) project suggests that gains and losses of metal transporter genes occur frequently and correlate well with transporter gene expression levels. Hereby they may confer a cancer-driving selective growth advantage at early and possibly also later stages during cancer development. This idea is consistent with recent observations in yeast, which suggest that through chromosomal gains and losses cells can adapt quickly to new carbon sources 10 , nutrient starvation 11 as well as to copper toxicity 12 . In human cancer development, candidate driving events may include, among others, the gains of zinc transporter genes SLC39A1 and SLC39A4 on chromosome arms 1q and 8q, respectively, and the losses of zinc transporter genes SLC30A5, SLC39A14 and SLC39A6 on 5q, 8p and 18q. The recurrent gain of 3q might be associated with the iron transporter gene TFRC and the loss of 13q with the copper transporter gene ATP7B. By altering cellular trace element homeostasis such events might contribute to the initiation of the malignant transformation. Intriguingly, attenuation or overexpression of several of these metal transporter genes has been shown to lead to malignant cellular behavior in vitro. Consistently, it has been shown that zinc affects a number of the observed "hallmarks of cancer" characteristics including DNA repair, inflammation and apoptosis, e.g. through its effects on NF-kappa B signaling. We term this model the "aneuploidy metal transporter cancer" (AMTC) hypothesis and find it compatible with the cancer-promoting role of point mutations and focal copy number alterations in established tumor suppressor genes and oncogenes (e.g. MYC, MYCN, TP53, PIK3CA, BRCA1, ERBB2). We suggest a number of approaches for how this hypothesis could be tested experimentally and briefly touch on possible implications for cancer etiology, metastasis, drug resistance and therapy.. CC-BY-NC 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/002105 doi: bioRxiv preprint first posted online Jan. 29, 2014; [3...

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Section: Chemotherapeutic Agents and Resistancementioning

confidence: 83%

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

Engelken

Altmeyer

2014

Preprint

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“…The removal of Cs(I), Sr(II), Mn(II), Co(II), Cu(II), Zn(II), and Cr(III) ions from aqueous solutions using the anionic SDS surfactant was investigated by Juang et al [13]. The MEUF method was also applied for the removal of Cd(II), Pb(II), Cu(II), Ni(II), and Zn(II) using natural surfactants, such as deoxycholic acid and lecithins [14], as well as for the removal of Cu(II) and other heavy metals from real industrial wastewaters originating from a metal finishing plant, using the sodium salt of deoxycholic acid (DCA) [15]. The derivatives of cholesterol (DCA and taurocholic acid) and SDS applied in the MEUF method for removal of Cd(II), Cu(II), Ni(II), Pb(II) and Zn(II) show the strongest binding of SDS and DCA in singleand multicomponent solutions, respectively [16].…”

Section: Introductionmentioning

confidence: 99%

Removal of Copper(II) in the Presence of Sodium Dodecylobenzene Sulfonate from Acidic Effluents Using Adsorption on Ion Exchangers and Micellar-Enhanced Ultrafiltration Methods

2022

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The selective removal of Cu(II) in the presence of sodium dodecylobenzene sulfonate from acidic effluents was made using the adsorption and micellar-enhanced ultrafiltration methods. Lewatit MonoPlus TP220 showed the best adsorption behavior in the systems containing Cu(II) in the presence of ABSNa50 surfactant compared to the other adsorbents (removal efficiency ≈ 100%, sorption capacity ≈ 10 mg/g). The kinetics followed the pseudo-second order kinetic equation. The Langmuir adsorption capacities were 110 mg/g (the system with ABSNa50 above CMC) and 130.38 mg/g (the system with ABSNa50 below CMC). The working ion exchange capacities were Cw = 0.0216 g/mL and Cw = 0.0135 g/mL. The copper removal by the micellar-enhanced ultrafiltration method was 76.46% (0.1 mol/L HCl).

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“…[6] The use of thin-layer chromatography (TLC) for the study of such interactions has marked advantages: the method is generally rapid, it is easy to carry out, it makes possible the simultaneous determination of numerous interactions on one plate, and the amount of the more hydrophobic interactive compounds is extremely low. [7] Because of their advantageous physico-chemical characteristics, nonionic surfactants are frequently used in a wide variety of industrial processes, such as in agrochemical plant protection to increase the efficacy of the active ingredient, [8] in waste-water treatment to promote biodegradation of pollutants, [9] in biotechnology to accelerate fermentation processes, [10] in pharmaceutical formulation to enhance beneficial effects, [11] etc. However, nonionic surfactants show marked adversary effects too.…”

Section: Introductionmentioning

confidence: 99%

TLC Study of the Binding of Nonionic Surfactants to the Corn Protein Zein

Cserháti

Forgács

Illés³

2003

Journal of Liquid Chromatography & Related Technologies

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The binding of 18 nonionic surfactants with various lengths of apolar ethylene oxide chains to the corn protein zein was studied by thin-layer chromatography (TLC) carried out on alumina layers covered with zein, and the effect of methanol, monovalent cations, and pH on the strength and selectivity of interaction was elucidated by using the spectral mapping technique and stepwise regression analysis. The binding of surfactants to zein has been demonstrated. It has been established that the number of hydrophilic ethylene oxide units in the surfactant molecule exerts the highest influence on the strength of interaction, and that the role of methanol and salt concentration is of secondary importance.The character of the cation and pH influenced both the strength and selectivity of the surfactant-zein interaction.

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Surfactant-Enhanced Ultrafiltration of Heavy Metals from Waste Streams with Pilot-Scale System

Cited by 20 publications

References 2 publications

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

Removal of Copper(II) in the Presence of Sodium Dodecylobenzene Sulfonate from Acidic Effluents Using Adsorption on Ion Exchangers and Micellar-Enhanced Ultrafiltration Methods

TLC Study of the Binding of Nonionic Surfactants to the Corn Protein Zein

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