Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy

Mindroiu, Mihaela; Ion, Raluca; Pîrvu, Cristian; Cîmpean, Anișoara

doi:10.1016/j.msec.2013.04.016

Cited by 15 publications

(13 citation statements)

References 41 publications

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“…The relation between material roughness and cytokine production by endothelial cells or macrophages is very scarce in literature, and most often they concern alloy‐based materials …”

Section: Discussionmentioning

confidence: 99%

Exudation of additives to the surface of medical devices: impact on biocompatibility in the case of polyurethane used in implantable catheters

Nouman

Jubeli

Saunier

et al. 2016

J. Biomed. Mater. Res.

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Surface state is one of the most important parameters determining the biocompatibility of an implantable medical device, any change on the surface once in contact with body tissues can impact the biological response (cytotoxicity, inflammation, irritation, thrombosis, etc.). In the present study, we use (Pellethane ) catheter-based polyurethane (PU), because of its many applications in the field of medical devices, to evaluate the impact of additives blooming on the biocompatibility. Four different antioxidants and two anti-ultraviolet stabilizers were included in this study. A comprehensive study was conducted to evaluate the consequences of cellular exposure to theses additives in the following three forms: in dissolved form and after surface blooming, in amorphous and in crystalized ones, and finally in the overall biocompatibility of the native PU. Surface roughness was analyzed with atomic force microscopy. Endothelial cells' viability was studied in contact with all the three physical forms. A preliminary hemocompatibility evaluation was performed through the measurement of whole blood hemolysis, as well as platelet adhesion in contact with the different PU samples. The study of the proinflammatory IL-α and TNF-α production by macrophages in contact with these films is also reported. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2954-2967, 2016.

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“…The relation between material roughness and cytokine production by endothelial cells or macrophages is very scarce in literature, and most often they concern alloy‐based materials …”

Section: Discussionmentioning

confidence: 99%

Exudation of additives to the surface of medical devices: impact on biocompatibility in the case of polyurethane used in implantable catheters

Nouman

Jubeli

Saunier

et al. 2016

J. Biomed. Mater. Res.

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“…The surface wettability was greatly influenced by the type of surfactant added. Indeed, the highest hydrophilic character was observed for PPy/PSS films, with respect to PPy/Triton X-100 and PPy/DM ones [74].…”

Section: Contact Anglementioning

confidence: 96%

“…On the other hand, PLGA-PPy[Dex]-Ti samples developed by Sirivisoot and coworkers were analyzed by AFM in non-contact mode, highlighting that cell adhesion was improved by surface roughness. Indeed, PLGA-PPy[Dex]-Ti exhibited the highest Rrms (i.e., (Root Mean Square roughness) among all the samples [74].…”

Section: Atomic Force Microscopymentioning

confidence: 99%

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

et al. 2020

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The understanding of chemical–physical, morphological, and mechanical properties of polymer coatings is a crucial preliminary step for further biological evaluation of the processes occurring on the coatings’ surface. Several studies have demonstrated how surface properties play a key role in the interactions between biomolecules (e.g., proteins, cells, extracellular matrix, and biological fluids) and titanium, such as chemical composition (investigated by means of XPS, TOF-SIMS, and ATR-FTIR), morphology (SEM–EDX), roughness (AFM), thickness (Ellipsometry), wettability (CA), solution–surface interactions (QCM-D), and mechanical features (hardness, elastic modulus, adhesion, and fatigue strength). In this review, we report an overview of the main analytical and mechanical methods commonly used to characterize polymer-based coatings deposited on titanium implants by electro-assisted techniques. A description of the relevance and shortcomings of each technique is described, in order to provide suitable information for the design and characterization of advanced coatings or for the optimization of the existing ones.

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“…Only the surfaces of TiNbTaZr oxidized at 800 8C exhibited a water contact angle u > 65 8 (defined as hydrophobic surfaces). However, it is known that the wettability can significantly influence the cell adhesion [33,34].…”

Section: Contact Angle Measurementsmentioning

confidence: 99%

The estimation of corrosion behavior of thermal oxidized TiNbTaZr alloys for biomedical applications

Mareci

Bolat

Munteanu

et al. 2014

Materials & Corrosion

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The corrosion behavior of two oxidized TiNbTaZr alloys (Ti25Nb8Ta10Zr and Ti21Nb15Ta6Zr) at 500 and 800 °C for 2‐h in 0.9 wt% NaCl solution are evaluated. Both samples were examined using electrochemical techniques: electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization curves. The electrochemical corrosion parameters obtained from the EIS and potentiodynamic polarization curves indicated a typical passive behavior for untreated and oxidized TiNbTaZr alloys. EIS studies showed high impedance values for both oxidized samples, increasing with exposure time. The polarization results show excellent corrosion resistance for oxidized TiNbTaZr alloys, corroborated by the low corrosion and anodic current density. The oxidation in air at 500 and 800 °C do not exhibit the susceptibility of localized corrosion processes in 0.9 wt% NaCl solution. In addition, scanning electron microscopy (SEM) was employed to observe the surface morphology after polarization test in 0.9 wt% NaCl solution. The oxidized Ti21Nb15Ta6Zr alloy appears to possess superior corrosion resistance than the oxidized Ti25Nb8Ta10Zr alloy in 0.9 wt% NaCl solution.

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Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy

Cited by 15 publications

References 41 publications

Exudation of additives to the surface of medical devices: impact on biocompatibility in the case of polyurethane used in implantable catheters

Exudation of additives to the surface of medical devices: impact on biocompatibility in the case of polyurethane used in implantable catheters

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

The estimation of corrosion behavior of thermal oxidized TiNbTaZr alloys for biomedical applications

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