Surfactant-assisted synthesis of hydroxyapatite particles: a comprehensive review

Prasad, P. Siva; Marupalli, Bharat C.G.; Das, Siddhartha; Das, Karabi

doi:10.1007/s10853-023-08366-x

Cited by 13 publications

(5 citation statements)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydroxyapatite is easily synthesized with different external forms, which could have an influence on drug loading and subsequent release. The most diffused are the spherical nanoparticles, but nanorods, flower-like, plate-like, and dumbbell-like nanoparticles are also reported [ 14 ]. The different surface areas and the possible porosities obtained during synthesis are fundamental parameters for the efficacy of drug release systems based on HAP , with the adsorption phenomenon being at the basis of hybrid formation.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

Friuli,

Maggi,

Bruni

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

Poorly water-soluble drugs represent a challenge for the pharmaceutical industry because it is necessary to find properly tuned and efficient systems for their release. In this framework, organic–inorganic hybrid systems could represent a promising strategy. A largely diffused inorganic host is hydroxyapatite (HAP, Ca10(PO4)6(OH)2), which is easily synthesized with different external forms and can adsorb different kinds of molecules, thereby allowing rapid drug release. Hybrid nanocomposites of HAP nanorods, obtained through hydrothermal synthesis, were prepared with two model pharmaceutical molecules characterized by low and pH-dependent solubility: meloxicam, a non-steroidal anti-inflammatory drug, and bumetanide, a diuretic drug. Both hybrids were physically and chemically characterized through the combined use of X-ray powder diffraction, scanning electron microscopy with energy-dispersive spectroscopy, differential scanning calorimetry, and infrared spectroscopy measurements. Then, their dissolution profiles and hydrophilicity (contact angles) in different media as well as their solubility were determined and compared to the pure drugs. This hybrid system seems particularly suitable as a drug carrier for bumetanide, as it shows higher drug loading and good dissolution profiles, while is less suitable for meloxicam, an acid molecule.

show abstract

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

Friuli,

Maggi,

Bruni

et al. 2024

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Among biosurfactants, surfactin emerges as a highly effective option, offering advantages such as abundance, high biodegradability, and nonhemolytic characteristics. Notably, surfactin exhibits biocompatibility, biodegradability, and a spectrum of antimicrobial properties, making it a highly promising candidate for various biomedical applications …”

Section: Introductionmentioning

confidence: 99%

“…Notably, surfactin exhibits biocompatibility, biodegradability, and a spectrum of antimicrobial properties, making it a highly promising candidate for various biomedical applications. 17 The incorporation of metallic ions like Cu 2+ , Ag + , Zn 2+ , Sr 2+ , and Ce + in CaP began due to their antibacterial properties and decreased cytotoxicity at low concentrations. 18,19 Among these, Cu holds importance in living organisms because of its antibacterial activity and its ability to enhance the activity of several enzymes.…”

Section: Introductionmentioning

confidence: 99%

Biosurfactant-Assisted Cu Doping of Brushite Coatings: Enhancing Structural, Electrochemical, and Biofunctional Properties

Siva Prasad,

Byram,

Hazra

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Stainless steel (316L SS) has been widely used in orthopedic, cardiovascular stents, and other biomedical implant applications due to its strength, corrosion resistance, and biocompatibility. To address the weak interaction between steel implants and tissues, it is a widely adopted strategy to enhance implant performance through the application of bioactive coatings. In this study, Cu-doped brushite coatings were deposited successfully through pulse electrodeposition on steel substrates facilitated with a biosurfactant (BS) (i.e., surfactin). Further, the combined effect of various concentrations of Cu ions and BS on the structural, electrochemical, and biological properties was studied. The X-ray diffraction (XRD) confirms brushite composition with Cu substitution causing lattice contraction and a reduced crystallite size. The scanning electron microscopy (SEM) and energydispersive spectroscopy (EDS) studies reveal the morphological changes of the coatings with the incorporation of Cu, which is confirmed by X-ray photoelectron spectroscopy (XPS) and elemental mapping. The Fourier transform infrared (FTIR) and Raman spectroscopy confirm the brushite and Cu doping in the coatings, respectively. Increased surface roughness and mechanical properties of Cu-doped coatings were analyzed by using atomic force microscopic (AFM) and nanohardness tests, respectively. Electrochemical assessments demonstrate corrosion resistance enhancement in Cu-doped coatings, which is further improved with the addition of biosurfactants. In vitro biomineralization studies show the Cu-doped coating's potential for osseointegration, with added stability. The cytocompatibility of the coatings was analyzed using live/dead and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays; cell adhesion, proliferation, and migration studies were evaluated using SEM. Antibacterial assays highlight significant improvement in the antibacterial properties of Cu-doped coatings with BS. Thus, the developed Cudoped brushite coatings with BS demonstrate their potential in the realm of biomedical implant technologies, paving the way for further exploration.

show abstract

“…It is an effective method to prepare nano or microcrystals for using surfactants as soft templates [23] . The crystals are generated within or around the limitary volume or space of the template.…”

Section: Introductionmentioning

confidence: 99%

Surfactant-Assisted Synthesis of Ca<sub>3</sub>(BTC)<sub>2 </sub>Metal-Organic Framework for the Removal of Heavy Metal

Wang,

Liu,

Chen

et al. 2024

Preprint

View full text Add to dashboard Cite

Novel Ca3(BTC)2 metal-organic frameworks with different sizes and shapes constructed by Ca2+ and trimesic acid as metal center and ligands respectively were synthesized by a surfactant-assisted method. The relationship between the quantity of surfactant and the particle morphology of the product have been further studied. The samples were characterized by scanning electron microscope, powder X-ray diffraction and Inductively coupled plasma mass spectrometry. The results indicated that the size and shape of Ca3(BTC)2 could be regulated by changing the quantity of surfactant. Rod- and sheet-like Ca3(BTC)2 MOFs have been readily availabled. The removal kinetics of heavy metals of Pb(II) were also studied by rod-like Ca3(BTC)2. The results showed that as-synthesized Ca3(BTC)2 could effectively remove heavy metals of Pb(II) from the sewage.

show abstract

Surfactant-assisted synthesis of hydroxyapatite particles: a comprehensive review

Cited by 13 publications

References 195 publications

Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

Hydroxyapatite Nanorods Based Drug Delivery Systems for Bumetanide and Meloxicam, Poorly Water Soluble Active Principles

Biosurfactant-Assisted Cu Doping of Brushite Coatings: Enhancing Structural, Electrochemical, and Biofunctional Properties

Surfactant-Assisted Synthesis of Ca<sub>3</sub>(BTC)<sub>2 </sub>Metal-Organic Framework for the Removal of Heavy Metal

Contact Info

Product

Resources

About