Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis

Şen, Semra; Kamit, Fulya; İşgüder, Rana; Yazici, Pınar; Bal, Zümrüt Şahbudak; Devrim, İlker; Bayram, Nuri; Karapınar, Bülent; Anıl, Ayşe Berna; Vardar, Fadıl

doi:10.1007/s12098-020-03355-3

Cited by 4 publications

(8 citation statements)

References 21 publications

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“…Of the studies included, four used TREM-1 as a predictive biomarker 9,11,14,15 , four used it for diagnosis purposes 6,10,12,13 , and two, as a prognostic marker 16,17 of sepsis in pediatric patients. As for the type of study, eight were primary surveys [9][10][11][12][13][15][16][17] and two were systematic reviews 6,14 . As for the LE, five papers were classified as 2C 9,10,12,13,17 , three as 3B 11,15,16 , and two as 2A 6,14 .…”

Section: Resultsmentioning

confidence: 99%

“…As for the type of study, eight were primary surveys [9][10][11][12][13][15][16][17] and two were systematic reviews 6,14 . As for the LE, five papers were classified as 2C 9,10,12,13,17 , three as 3B 11,15,16 , and two as 2A 6,14 . As for the number of patients involved, there were 1,409 in the primary studies [9][10][11][12][13][15][16][17] and 1,628 6,14 in the review studies.…”

Section: Resultsmentioning

confidence: 99%

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Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker

Cabral

Silveira

Xavier

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE: Triggering receptor expressed on myeloid cells-1 concentration can be used as a predictive, diagnostic, and prognostic marker in patients with sepsis. The objective of this study was to determine the validity of triggering receptor expressed on myeloid cells-1 levels as a biomarker of sepsis in pediatric patients. METHODS:This was an integrative literature review. PubMed, ScienceDirect, LILACS, MEDLINE, and VHL databases were searched for papers published between 2015 and 2020, using the keywords triggering receptor expressed on myeloid cells-1, sepsis, and child. RESULTS:The review included ten studies, of which four used triggering receptor expressed on myeloid cells-1 as a predictive biomarker; four, as a diagnostic biomarker; and two, as a prognostic biomarker. A total of 1,409 and 1,628 patients were included in primary and review studies, respectively. There was a predominance of significant results for the validity of triggering receptor expressed on myeloid cells-1 levels in the prediction, diagnosis, and prognosis of sepsis in pediatric patients.CONCLUSIONS: Triggering receptor expressed on myeloid cells-1 is a valid predictive, diagnostic, and prognostic biomarker of sepsis with good sensitivity and specificity in the pediatric population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker

Cabral

Silveira

Xavier

et al. 2021

Rev. Assoc. Med. Bras.

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“…Biomarkers have mainly been employed in sepsis management for four reasons: early diagnosis, determining the prognosis, staging, and monitoring the response to treatment. 13 Serum CRP is a biomarker involved in a variety of inflammatory diseases, and is a widely studied biomarker in sepsis patients. 1 Whether CRP is a good biomarker for early diagnosis of sepsis is still controversial, but a majority of hospitals can implement CRP analysis in sepsis diagnosis and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of sTREM1 and suPAR Biomarkers as Diagnostic and Prognostic Predictors in Sepsis Patients

El-din¹,

Abdel-Gawad²,

Abdelgalil³

et al. 2021

IDR

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Background:The purpose of this study was to explore the diagnostic role of sTREM1 in the diagnosis of sepsis and in differentiating between sepsis and systemic inflammatory response syndrome (SIRS). We also aimed to assess the prognostic value of suPAR in comparison to sequential organ-failure assessment (SOFA), acute physiology and chronic health evaluation (APACHE) II scores, and 28-day mortality. Methods: This was a cross-sectional study conducted in the Medical Microbiology and

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“…The cut-off of presepsin for discriminating between sepsis and SIRS was 407 pg/ml, with sensitivity and specificity values of 98.6% and 82.6%, respectively [48]. In a study of septic children, TREM-1 levels were higher in septic shock patients [49].…”

Section: Membrane Receptors Cell Proteins and Metabolitesmentioning

confidence: 96%

“…The absence of OCLN in the cerebral microvascular endothelium was related to more severe disease and intense inflammatory response PAI-1 Sepsis severity prognosis [33,34] Predictor of mortality Potential marker to distinguish Gram ( +) and Gram (-) bacterial infection TREM-1 Sepsis indicator [89][90][91] An early distinction between sepsis and SIRS…”

Section: Cldn-5mentioning

confidence: 99%

Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

et al. 2022

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A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to answer the question, "Do biomarkers in patients with sepsis or septic shock predict mortality, multiple organ dysfunction syndrome (MODS), or organ dysfunction?" We also discuss the role of pro- and anti-inflammatory biomarkers and biomarkers associated with intestinal permeability, endothelial injury, organ dysfunction, blood–brain barrier (BBB) breakdown, brain injury, and short and long-term mortality. For sepsis, a range of biomarkers is identified, including fluid phase pattern recognition molecules (PRMs), complement system, cytokines, chemokines, damage-associated molecular patterns (DAMPs), non-coding RNAs, miRNAs, cell membrane receptors, cell proteins, metabolites, and soluble receptors. We also provide an overview of immune response biomarkers that can help identify or differentiate between systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and sepsis-associated encephalopathy. However, significant work is needed to identify the optimal combinations of biomarkers that can augment diagnosis, treatment, and good patient outcomes.

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Surface TREM-1 as a Prognostic Biomarker in Pediatric Sepsis

Cited by 4 publications

References 21 publications

Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker

Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker

Evaluation of sTREM1 and suPAR Biomarkers as Diagnostic and Prognostic Predictors in Sepsis Patients

Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

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