Surface rejuvenating effect of Achillea millefolium extract

Pain, Stéphanie; Altobelli, C; Boher, Aurélie; Cittadini, L; Favre-Mercuret, M; Gaillard, Carlo A. J. M.; Sohm, B.; Vogelgesang, B; André-Frei, V.

doi:10.1111/j.1468-2494.2011.00667.x

Cited by 27 publications

(18 citation statements)

References 12 publications

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“…Pain et al () evaluated the effect of A. millefolium extract on the expression pattern of various epidermal differentiation markers in normal human skin biopsies using quantitative image analysis and second to evaluate its capacity to rejuvenate the appearance of skin surface in vivo . Study showed that A. millefolium extract improved the expression profile of various epidermal differentiation markers (cytokeratin 10, transglutaminase‐1 and filaggrin) in cultured skin biopsies as well as increased epidermal thickness.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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Achillea millefoilum L. (Yarrow) is an important species of Asteraceae family with common utilization in traditional medicine of several cultures from Europe to Asia for the treatment of spasmodic gastrointestinal disorders, hepatobiliary, gynecological disorders, against inflammation and for wound healing. An extensive review of literature was made on A. millefoilum L. using ethno botanical text books, published articles in peer-reviewed journals, unpublished materials and scientific databases. The Plant List, International Plant Name Index and Kew Botanical Garden databases were used to authenticate the scientific names. Monoterpenes are the most representative metabolites constituting 90% of the essential oils in relation to the sesquiterpenes, and a wide range of chemical compounds have also been reported. Different pharmacological experiments in many in-vitro and in-vivo models have proved the potential of A. millefoilum with antiinflammatory, antiulcer, anticancer activities etc. lending support to the rationale behind numerous of its traditional uses. Due to the noteworthy pharmacological activities, A. millefoilum will be a better option for new drug discovery. The present review will comprehensively summarize the pharmacognosy, phytochemistry and ethnopharmacology of A. millefoilum reported to date, with emphasis on more in vitro, clinical and pathological studies needed to investigate the unexploited potential of this plant. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

2017

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“…Am extract showed an augmentation in cytokeratin-10, transglutaminase-1, and filaggrin expressions, together with an increase in the thickness of epidermis in cultured skin biopsies. In addition, a 2-month topical application of 2% Am extract significantly improved the outlook of wrinkles and pores in vivo when compared with placebo (36).…”

Section: Discussionmentioning

confidence: 92%

A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study

Pekmezci

Dündar²,

Türkoğlu³

2018

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction:Currently there are only a limited number of drugs available for treatment of androgenetic alopecia and telogen effluvium. However, certain plants and their standardized extracts may provide some clinical benefits against hair loss. We formulated a herbal shampoo and a solution to evaluate their efficacy, safety, and synergy in hair loss. Methods: We conducted a randomized, placebo-controlled, single-blind, clinical and instrumental study for 6 months on 120 subjects with androgenetic alopecia and telogen effluvium, confirmed by pull test and phototricogram. Each subject was examined monthly. At the end of the study, a self-assessment test was carried out. Results: Herbal formulations were found to be more effective in preventing and reducing hair loss than placebo at every assessment point. Anagen/telogen ratios improved significantly in the study group. In addition, concomitant use of the shampoo and solution were found to be more effective than single product use. Conclusion: We interpret this eutrophic effect for scalp hair as the final outcome of the entire content of our herbal formula, which has antiandrogenic, anti-inflammatory, antioxidative, angiogenic, and hair-stimulating features. In combination, these features help prevent hair from falling out and reducing hair loss.

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“…Am extract showed an improved expression profile of cytokeratin-10, transglutaminase-1 and filaggrin in cultured skin biopsies as well as an increase in epidermal thickness. Also in vivo a two month treatment with 2% Am extract significantly improved the appearance of wrinkles and pores compared to placebo ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

Pekmezci¹,

Dündar²,

Türkoğlu³

2018

Med Arch

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BackgroundCurrently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features.Materials and MethodsIn addition to performing the phytochemical analysis of HE, we detected the gene expression level of IL-1α, the crucial hair loss mediator, for the putative efficacy in nonscarring alopecia. Cell proliferation assay was performed by XTT reagent. After determination of non-cytotoxic concentration, HaCaT cells were treated with HE. RNA isolations were carried out from both non-treated and treated cell groups by using TRI-reagent. Gene expressions of IL-1α and as control GAPDH were determined by RT-qPCR analysis.ResultsResults were represented as “IL-1α/GAPDH Fold Change”. HE solution caused statistically significant downregulation of IL-1α gene expressions (p<0.0001), compared to untreated control cells. HE treatment ended up with 0.1900 fold change for IL-1α.ConclusionIL-1α is a direct growth inhibitory agent in hair follicles and an important actor in the pathogenesis of AGA , TE, and AA. Considering together the vitamins, flavonoids, and trace elements identified in the phytochemical analyses and downregulation of IL-1α in HaCaT cells, our HE may be an auxiliary agent in the therapy of these three nonscarring alopecia forms.

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Surface rejuvenating effect of Achillea millefolium extract

Cited by 27 publications

References 12 publications

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

Pharmacognosy, Phytochemistry and Pharmacological Properties ofAchillea millefoliumL.: A Review

A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study

Proprietary Herbal Extract Downregulates the Gene Expression of Il-1 and #945; in HaCaT Cells: Possible Implications Against Nonscarring Alopecia

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