Surface Properties and Compatibility with Blood of New Quaternized Polysulfones

Albu, Raluca Marinica; Avram, Ecaterina; Stoica, Iuliana; Ioanid, Emil Ghiocel; Popovici, Dumitru; Ioan, Silvia

doi:10.4236/jbnb.2011.22015

Cited by 19 publications

(15 citation statements)

References 30 publications

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“…[21] When blood is exposed to a biomaterial surface, adhesion of cells occurs and the extent of adhesion decides the life of the implanted biomaterials; thus, cellular adhesion to biomaterial surfaces could activate coagulation and the immunological cascades. [22] where W s -work of spreading (the negative free energy associated with spreading liquid over the solid surface);…”

Section: Contact Angle and Surface Free Energymentioning

confidence: 99%

Tailorable polyelectrolyte protein complex based on poly(aspartic acid) and bovine serum albumin

Niţă¹,

Chiriac²,

Stoleru³

et al. 2016

Designed Monomers and Polymers

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Protein-polyelectrolyte complexes (PPC) are playing an important role in a variety of chemical and biological processes, such as protein separation, enzyme stabilization, and polymer drug delivery. The present investigation is focused on evaluation of the PPC formation between a synthetic polypeptide (poly(aspartic acid) -PAS) and a natural protein (bovine serum albumin -BSA). The PPC obtained from PAS and BSA in different ratio was investigated by corroboration of various techniques of characterization as: spectroscopy, microscopy, thermogravimetric analysis, dynamic light scattering (DLS), and zeta potential determination, measurements which were performed in static and/or dynamic conditions. The static contact angle of the sample films was also determined in order to evaluate the changes brought upon surface free energy of the prepared PPCs in interdependence with the complexes composition. The critical conditions for complex formation in BSA-polyelectrolyte systems were underlined. The phenomenon was better evidenced in case of a ratio of 1/1 wt between the two polymers, both in static and/or dynamic conditions.

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Section: Contact Angle and Surface Free Energymentioning

confidence: 99%

Tailorable polyelectrolyte protein complex based on poly(aspartic acid) and bovine serum albumin

Niţă¹,

Chiriac²,

Stoleru³

et al. 2016

Designed Monomers and Polymers

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“…When blood is exposed to a biomaterial surface, adhesion of cells occurs and the extent of adhesion decides the life of the implanted biomaterials; thus, cellular adhesion to biomaterial surfaces could activate coagulation and immunological cascades [35]. Therefore, cellular adhesion has a direct influence on the thrombogenicity and immunogenicity of a biomaterial, thus dictating its blood compatibility.…”

Section: Methodsmentioning

confidence: 99%

“…The materials with lower work of adhesion would show a lower extent of cell adhesion than those with a higher work of adhesion. Polymer interactions with red blood cells are mediated mostly by the hydrophobic interactions with the lipid bilayer (the red blood cell hydrophobic layer containing transmembrane proteins) while the electrostatic interactions of the polymer with the surface charges are mediated by the direct interaction with membrane proteins, depending on the polymer characteristics [35]. …”

Section: Methodsmentioning

confidence: 99%

“…The surface free energy of biomaterials and the corresponding values of the work of spreading can be used as characterization parameters for predicting cell spreading onto their surfaces and hence, for establishing their blood compatibility [35,36]. As work of adhesion measures the ease with which cells can adhere, determination of the work of adhesion for different cells can help a biomaterial scientist to predict the manner in which blood cells would react when they are exposed to a biomaterial.…”

Section: Methodsmentioning

confidence: 99%

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Hybrid Nanostructures Containing Sulfadiazine Modified Chitosan as Antimicrobial Drug Carriers

et al. 2016

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Chitosan (CH) nanofibrous structures containing sulfadiazine (SDZ) or sulfadiazine modified chitosan (SCH) in the form of functional nanoparticles attached to nanofibers (hybrid nanostructures) were obtained by mono-axial and coaxial electrospinning. The mono-axial design consisted of a SDZ/CH mixture solution fed through a single nozzle while the coaxial design consisted of SCH and CH solutions separately supplied to the inner and outer nozzle (or in reverse order). The CH ability to form nanofibers assured the formation of a nanofiber mesh, while SDZ and SCH, both in form of suspensions in the electrospun solution, assured the formation of active nanoparticles which remained attached to the CH nanofiber mesh after the electrospinning process. The obtained nanostructures were morphologically characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The SDZ release profiles and kinetics were analyzed. The SDZ or SCH nanoparticles loosely attached at the surface of the nanofibers, provide a burst release in the first 20 min, which is important to stop the possible initial infection in a wound, while the SDZ and SCH from the nanoparticles which are better confined (or even encapsulated) into the CH nanofibers would be slowly released with the erosion/disruption of the CH nanofiber mesh.

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“…Previous investigations [14, 15] showed the predominant hydrophobic characteristics of some quaternized polysulfones (PSF‐DMEA and PSF‐DMOA) obtained by chloromethylate polysulfones with tertiary amines − N , N ‐dimethylethylamine (DMEA) and N , N ‐dimethyloctylamine (DMOA) [16–18]. Studies have been carried out for obtaining water‐soluble polymers with various amounts of ionic chlorine.…”

Section: Introductionmentioning

confidence: 99%

Miscibility and morphological properties of quaternized polysulfone blends with polystyrene and poly(4‐vinylpyridine)

Albu¹,

Avram²,

Stoica³

et al. 2011

Polymer Composites

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Quaternized polysulfones were synthesized by the quaternization reaction of chloromethylated polysulfone with different tertiary amines −N,N‐dimethylethylamine (DMEA) and N,N‐dimethyloctylamine (DMOA), respectively. New blends from these quaternized polysulfones (PSF‐DMEA or PSF‐DMOA) with polystyrene (PS) or poly(4‐vinylpyridine) (P4VP) were prepared by the solution casting method. Pure quaternized polysulfones, in N,N‐dimethylformamide (DMF)/methanol (MeOH) and DMF/water solvent/nonsolvent mixtures, and their blends with PS and P4VP, as well, were investigated by shear viscometry and viscoelasticity, atomic force microscopy, differential scanning calorimetry, and surface properties. The results obtained revealed that the blends have good miscibility. Surface morphology is characterized by roughness and nodules formations, depending on the alkyl radical lengths, composition of the polymer mixtures, including specific electron‐donor or electron‐acceptor characteristics of polymers. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers

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Surface Properties and Compatibility with Blood of New Quaternized Polysulfones

Cited by 19 publications

References 30 publications

Tailorable polyelectrolyte protein complex based on poly(aspartic acid) and bovine serum albumin

Tailorable polyelectrolyte protein complex based on poly(aspartic acid) and bovine serum albumin

Hybrid Nanostructures Containing Sulfadiazine Modified Chitosan as Antimicrobial Drug Carriers

Miscibility and morphological properties of quaternized polysulfone blends with polystyrene and poly(4‐vinylpyridine)

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